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Faculty Detail    
Name WILLIAM J COOK
 
Campus Address HSB 138 Zip 6823
Phone 205-975-8319
E-mail wjcook@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor Emeritus

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Cook was born in Tuscaloosa, AL. He received his MD and Ph.D. from the University of Alabama at Birmingham. After an internship in pathology at UAB, he completed his residency training in pathology at the National Institutes of Health in Bethesda, MD. He joined the Department of Pathology at the University of Alabama at Birmingham in 1978. In addition to his clinical activities, he served as Associate Director of the Center for Macromolecular Crystallography from 1991 to 1994. In 1994 he left UAB for a sixteen month period to serve as Senior Vice President of Research & Development for BioCryst Pharmaceuticals, Inc., in Birmingham, AL. He returned to UAB in 1996 as Professor of Pathology and Head of Special Procedures and Organ Pathology. In 2007 he was appointed Professor Emeritus. His subspecialty interest is renal pathology. He continues to do research in protein crystallography.

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology     
International Academy of Pathology     
International Society of Nephrology      
Renal Pathology Society     

Research/Clinical Interest
Title
Description
My clinical research includes various topics in renal pathology. My basic research has focused on protein structure and function, using X-ray crystallography. My current interests include structural studies of parasitic and bacterial enzymes.

Selected Publications 
Publication PUBMEDID
Cook, W.J., Senkovich, O. & Chattopadhyay, D. (2011) Structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein (ARFGAP). Acta Crystallogr. F67:1339-1344.  22102228 
Cook, W.J., Smith, C.D., Senkovich, O., Holder, A.A. & Chattopadhyay, D. (2010) Crystal structure of Plasmodium falciparum ADP-ribosylation factor 1. Acta Crystallogr. F66:1426-1431.  21045287 
Bell, E.K., Chugh, S.S., Cook, W.J. (2010) A case of infection-associated antiproteinase-3-negative cytoplasmic antineutrophil cytoplasmic antibody pauci-immune focal necrotizing glomerulonephritis. Nephrol. Dial. Transplant. 25:3119-3123.   20566570 
Cook, W.J., Galakatos, N., Boyar, W.C., Walter, R.L. & Ealick, S.E. (2010) Structure of human desArg-C5a. Acta Crystallogr. D66:190-197.  20124699  
Fogo AB, Bostad L, Svarstad E, Cook WJ, Moll S, Barbey F, Geldenhuys L, West M, Ferluga D, Vujkovac B, Howie AJ, Burns A, Reeve R, Waldek S, Noël LH, Grünfeld JP, Valbuena C, Oliveira JP, Müller J, Breunig F, Zhang X, Warnock DG. (2010) Scoring system for renal pathology in Fabry disease: report of the International Study Group of Fabry Nephropathy (ISGFN). Nephrol Dial Transplant. 25:2168-2177.  19833663 
Burgos, P.I., Perkins, E.L., Pons-Estel, G.J., Kendrick, S.A., Liu, J.M., Kendrick, W.T., Cook, W.J., Julian, B.A., Alarcón, G.S. & Kew, C.E. II. (2009) Risk factors and impact of recurrent lupus nephritis in patients with systemic lupus erythematosus undergoing renal transplantation: Data from a single US institution. Arthritis Rheum. 60:2757-2766.  19714623 
Cook, W.J., Senkovich, O. & Chattopadhyay, D. (2009) An unexpected phosphate binding site in glyceraldehyde 3-phosphate dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme. BMC Struct. Biol. 9:9.  19243605 
Pintavorn, P. & Cook, W.J. (2008) Progressive renal insufficiency associated with amiodarone-induced phospholipidosis. Kidney Int. 74:1354-1357.  18528322 
Diskin, C.J., Stokes, T.J., Dansby, L.M., Radcliff, L., Carter, T.B., Graves, E., Byron, D. & Cook, W.J. (2007) Acute renal failure due to a primary renal B cell lymphoma. Am. J. Kidney Dis. 50:885-889.   17954302 
Senkovich, O., Cook, W.J., Mirza, S., Hollingshead, S.K., Protasevich, I.I., Briles, D.E. & Chattopadhyay, D. (2007) Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein A provides insight into microbial defense mechanism. J Mol. Biol. 370:701-713.  17543335 

Keywords
protein crystallography, renal pathology