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Faculty Detail    
Name ROBIN D HATTON
 
Campus Address BBRB 870 Zip 2170
Phone 205-975-5537
E-mail rdzialo@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Associate Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Associate Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Hatton is an Associate Professor in the Department of Pathology. She received a BS (1987) in Biotechnology from Worcester Polytechnic Institute and a PhD from the Department of Microbiology at UAB in 1996. Post-doctoral training was completed at UAB in 2001.

Society Memberships
Organization Name Position Held Org Link
American Association of Immunologists  Member  www.aai.org 
International Society for Interferon and Cytokine Research  member  www.isicr.org 

Research/Clinical Interest
Title
Molecular Mechanism of T Effector Cell Development
Description
The studies in our laboratory are concerned with the interactions of antigen presenting cells and CD4 T cells and their regulation during an immune response. My primary interest is the molecular mechanisms that drive effector T cell development both in normal and disease states, focusing specifically on the epigenetic and transcriptional regulation of the Th1 expressed molecules, interferon gamma (IFNg) and Fas ligand and the regulation of expression of IL-10 in regulatory T cells. We have identified a conserved distal regulatory element that is critical for lineage specific expression of IFNg and we are currently investigating its function in both activating and silencing IFNg expression. We have developed a powerful set of tools that includes a transgenic mouse system that allows for gene delivery into primary T cells, and the use of recombineering to develop BAC transgenic and gene targeted mice. The combination of both systems in addition to conventional molecular biological techniques allows for a unique approach to this very import aspect of the immune response

Selected Publications 
Publication PUBMEDID
Basu, R., O’Quinn, D.B., Silberger, D.J., Schoeb, T.R., Fouser, L., Ouyang, W., Hatton, R.D., and Weaver, C.T. 2012. Th22 Cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. 37(6):1061-75.   23200827 
Maynard, C.L., Elson, C.O., Hatton, R.D., and Weaver, C.T. 2012. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489:231-41.   22972296  
Hatton, R.D. 2011. TGF-beta in Th17 Cell Development: The Truth is Out There. Immunity 34(3):288-90.   21435582 
Balasubramani, A., Mukasa, R., Hatton, R.D., and Weaver, C.T.: Regulation of the Ifng locus in the context of T-lineage specification and plasticity. Immunol. Rev 2010 Nov;238(1):216-32.   2096959 
Balasubramani, A., Shibata, Y., Crawford, G.E., Baldwin, A.S., Hatton, R.D.*, and Weaver, C.T.*: Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity 2010 Jul 23;33(1):35-47. *contributed equally  20643337 
Mukasa, R., Balasubramani, A., Lee, Y.K., Whitley, S.K., Weaver, B.T., Shibata, Y., Crawford, G.E., Hatton, R.D.*, and Weaver, C.T.*: Epigenetic instability of cytokine and transcription factor gene loci underlie plasticity of the T helper 17 lineage. Immunity 2010 May 28;32(5):616-27. *contributed equally
 
2047129 
Weaver, C.T. and Hatton, R.D.: Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol. 2009 Dec;9(12):883-9.  19935807 
Schraml, B.U., Hildner, K., Ise, W., Lee, W.L., Smith, W.A., Solomon, B., Sahota, G., Sim, J., Mukasa, R., Cemerski, S., Hatton, R.D., Stormo, G.D., Weaver, C.T., Russell, J.H., Murphy, T.L., Murphy, K.M. : The AP-1 transcription factor Batf control T(H)17 differentiation. Nature. 2009 Jul 16;460(7253):405-9.
 
19578362 
Lee, Y.K., Mukasa, R., Hatton, R.D., Weaver, C.T.: Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol. 2009 Jun;21(3):274-80.  19524429  
Maynard CL, Hatton RD, Helms WS, Oliver JR, Stephensen CB, Weaver CT.
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.
J Exp Med. 2009 Feb 16;206(2):343-57. Epub 2009 Feb 9. 
19204112 
Weaver CT, Hatton RD, Mangan PR, Harrington LE.
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages.
Annu Rev Immunol. 2007 Jan 2; [Epub ahead of print] 
17201677 
Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT.
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.
Immunity. 2006 Nov;25(5):717-29. Epub 2006 Oct 26. 
17070076 
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT.
Transforming growth factor-beta induces development of the T(H)17 lineage.
Nature. 2006 May 11;441(7090):231-4.
 
16648837 
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT.
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Nat Immunol. 2005 Nov;6(11):1123-32.
 
16200070 
Cong Y, Konrad A, Iqbal N, Hatton RD, Weaver CT, Elson CO.
Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function.
J Immunol. 2005 Mar 1;174(5):2787-95.

 
15728488 
Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT.
Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells.
J Immunol. 2004 Dec 15;173(12):7249-58.
 
15585847 
Hatton, R.D, and Weaver, C.T.: T-bet or not T-bet. Science 302: 993, 2003.   14605354 
Hurez, V., Hatton, R.D., Oliver, J., Matthews, R.J., Weaver, C.T.: Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenovirial transduction. Immunol. Research, 26(1-3): 131, 2002.

 
12403352 
Hurez V.*, Dzialo-Hatton R.*, Oliver J., Matthews R.J., Weaver C.T.: Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model. BMC Immunology (2002) 3:4 (02 May 2002). *contributed equally.  12019030 
Dzialo-Hatton R, Milbrandt J, Hockett RD Jr, Weaver CT.: Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J Immunol. 2001 Apr 1;166(7):4534-42.  11254710 
Duality in the Th17-Treg developmental decision
Robin D Hatton and Casey T Weaver
F1000 Biology Reports 2009, 1:5 (21 January 2009)

 
 

Keywords
Th1/Th2/Th17, regulatory T cells, CD4 T cells, IL-10, Interferon gamma