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Faculty Detail    
Name MARISA MARQUES
 
Campus Address WP P230 Zip 7331
Phone 205-934-6421
E-mail mmarques@uab.edu
Other websites UAB Coagulation Service
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Laboratory Medicine Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
I received my M.D. degree from the Federal University of Rio Grande do Sul in Brazil, followed by residency in Internal Medicine at the same institution. I moved to the United States with my husband in 1986 to become a Research Fellow at the National Institutes of Health in Bethesda, Maryland, for 2 years. We then moved to Boston, where I continued working as a fellow at Harvard Medical School. In 1993, we relocated to Birmingham, Alabama. I completed a residency in Pathology and a fellowship in Hematopathology at UAB and am Board certified in Anatomic and Clinical Pathology, with subspecialties in Hematology and Transfusion Medicine/Blood Banking. I am currently an Associate Professor of Pathology at UAB, serving as Head for Hemostasis and Transfusion Medicine sections. In addition, I am Laboratory Director of the Immunocytopenia, Anesthesia and CICU laboratories. My main focus is patient care, teaching and administrative oversight of these laboratories. In the clinical arena, I am particularly interested in improving appropriateness of utilization and interpretation of laboratory tests used in the investigation and management of bleeding and thrombotic disorders. Along with the technologists staffing the Hemostasis laboratory, we provide clinical consultation as the UAB Coagulation Service (http://uabcoag.net). Since last year, I am developing a blood management program at UAB along with the Blood Utilization and Management Committee and many other colleagues from across the institution.

Society Memberships
Organization Name Position Held Org Link
Academy of Clinical Laboratory Physicians and Scientists (ACLPS)    http://depts.washington.edu/lmaclps 
American Association of Blood Banks    www.aabb.org 
American Society of Apheresis (ASFA)    www.apheresis.org 
American Society of Clinical Pathologists (ASCP)    www.ascp.org 
American Society of Hematology (ASH)    www.hematology.org 
College of Amercan Pathologists (CAP)    www.cap.org 
International Society on Thrombosis and Haemostasis    www.med.unc.edu/isth/ 

Research/Clinical Interest
Title
Description
I am interested in various aspects of clinical research in the fields of coagulation and transfusion medicine. Since UAB is a center of reference for apheresis, we receive patients from throughout Alabama and neighboring states to be treated here for thrombotic thrombocytopenic purpura (TTP). In the last several years, I have been involved in several projects about TTP as seen in my list of publications. Other areas of interest in Transfusion Medicine include the effect of storage time on the red blood cells and the repercussion for the patients, as well as transfusion-related acute lung injury (TRALI). In the area of coagulation, I have an interest in hypercoagulability, heparin-induced thrombocytopenia diagnosis, and cost-effective utilization of laboratory assays.

Selected Publications 
Publication PUBMEDID
Griffin D, Al-Nouri ZL, Muthurajah D, Ross JR, Ballard RB, Terrell DR, Vesely SK, George JN, Marques MB. First symptoms in patients with thrombotic thrombocytopenic purpura (TTP): what are they and when do they occur? Transfusion. 2013;53:235-7  23294213 
Deal T, Hovinga JAK, Marques MB, Adamski J. Novel ADAMTS13 Mutations in an obstetric patient with Upshaw-Schulman Syndrome. J Clin Apher. 2012 Dec 3. [Epub ahead of print]  23208954 
Passiment E, Meisel JL, Fontanesi J, Fritsma G, Aleryani SL, Marques MB. Decoding laboratory test names: A major challenge to appropriate patient care. J Gen Inter Med 2013;28:453-8.  23192446 
Tcherniantchouk O, Laposata M, and Marques MB. The isolated prolonged PTT. Am J Hematol 2013;88:82-5.  22811044 
Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, Holcomb JB, Illoh O, Kaplan LJ, Katz LM, Rao SV, Roback JD, Shander A, Tobian AA, Weinstein R, Swinton McLaughlin LG, Djulbegovic B; for the Clinical Transfusion Medicine Committee of the AABB. Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Intern Med 2012;157:49-58.  22751760 
Stapley R, Owusu BY, Brandon A, Cusick M, Rodriguez C, Marques MB, Kerby JD, Barnum SR, Weinberg JA, Lancaster Jr JR, Patel RP. Biochem J. 2012;446:499-508.  22720637 
Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest 2012;122:2661-71.  22684106 
Ballard RB, Marques MB; for the Education Committee of the Academy of Clinical Laboratory Physicians and Scientists. Pathology Consultation on the Laboratory Evaluation of Thrombophilia. Am J Clin Pathol. 2012;137(4):553-560.  22431530 
Adamski A, Hanna CA, Reddy VB, Litovsky SH, Evans CA, Marques MB. Multiorgan failure and bone marrow necrosis in three adults with sickle cell-+-thalassemia. Am J Hematol 2012;87:621-4.  22374850 
Marques MB, Polhill SR, Waldrum MR, Johnson JE, Timpa J, Patterson A, Salzman D.
How we closed the gap between red blood cell utilization and whole blood collections in our institution. Transfusion 2012; 52:1857-67.
 
22128835 
Marques MB, Schwartz J. Update on extracorporeal photopheresis in heart and lung transplantation. J Clin Apher. 2011;26:146-51.   21647952 
Marques MB, Fritsma GA.Von Willebrand disease laboratory diagnosis: the saga continues. Am J Clin Pathol. 2011;135:818-20.  21571953 
Marques MB, Anastasi J, Ashwood E, Baron B, Fitzgerald R, Fung M, Krasowski M, Laposata M, Nester T, Rinder HM; Academy of Clinical Laboratory Physicians and Scientists. The clinical pathologist as consultant. Am J Clin Pathol. 2011;135:11-2.  21173119 
Lima J, Reddy VV, Marques MB. Transfusion medicine illustrated. Systemic neutrophilic aggregates in transfusion-related acute lung injury. Transfusion. 2010;50:1427-8.  20636530 
Szczepiorkowski ZM, Winters JL, Bandarenko N, Kim HC, Linenberger ML, Marques MB, Sarode R, Schwartz J, Weinstein R, Shaz BH; Apheresis Applications Committee of the American Society for Apheresis. Guidelines on the use of therapeutic apheresis in clinical practice--evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis.J Clin Apher. 2010;25:83-177.  20568098 
Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, et al. Educating medical students in laboratory medicine: a proposed curriculum. Am J Clin Path 2010;133:533-42.  20231605  
Park YA, Waldrum MR, Marques MB. Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. Am J Clin Pathol 2010;133:460-5.  20154285 

Keywords
Thrombotic thrombocytopenic purpura (TTP), blood management