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Faculty Detail    
Name SHI WEI
MD, PhD, Associate Professor
 
Campus Address NP 3542 Zip 6823
Phone 205-996-7995
E-mail swei@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Associate Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He joined the faculty at UAB in July, 2008 and is currently a tenured Associate Professor. Dr. Wei is board certified in Anatomic and Clinical Pathology.

Society Memberships
Organization Name Position Held Org Link
American Society of Clinical Pathology  Fellow  http://ascp.org 
College of American Pathologists  Fellow  http://www.cap.org 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
United States and Canadian Academy of Pathology   Member  http://www.uscap.org 

Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, genitourinary and orthopedic pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, and tumor bone metastasis. Dr. Wei also serves as the Medical Director of Immunohistochemistry Laboratory of UAB Hospital, and co-directs the Histomorphometry & Molecular Analysis Core of the UAB Center for Metabolic Bone Disease.

Selected Publications 
Publication PUBMEDID
Xing D, Qasem SA, Owusu K, Zhang Z, Siegal GP, Wei S. Changing Prognostic Factors in Osteosarcoma: Analysis of 381 Cases from Two Institutions. Hum Pathol. In Press   
Brandwein-Gensler M, Wei S. Envisioning the Next WHO Head and Neck Classification. Head Neck Pathol. Mar 5. [Epub ahead of print]  24595418 
Dodd L, Wei S, Siegal GP. Optimal Handling of Bone Tumor Specimens. In: Histopathology: Methods and Protocols. Day C, Rhan R, Ed.; Springer. In Press.   
Ren Z, Li Y, Hameed O, Siegal GP, Wei S. Prognostic Factors in Patients with Metastatic Breast Cancer at the Time of Diagnosis. Pathol Res Pract. 2014 May;210(5):301-6. doi: 10.1016/j.prp.2014.01.008. Epub 2014 Feb 12.  24635972 
Wei S, Nagi C, Bleiwiess IJ, Jaffer S. Characteristics of Breast Carcinoma Cases with Falsely Negative Sentinel Lymph Nodes. Clin. Breast Cancer. 2014 Jan 3. pii: S1526-8209(13)00314-5. doi: 10.1016/j.clbc.2013.12.009. [Epub ahead of print].  24581736 
Wei S, Tanaka H, Seino Y. Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol. 1998 Oct;139(4):454-60.  9820625 
Wei S, Tanaka H, Seino Y. Vitamin D receptor. Nippon Rinsho. 1997 Apr;55 Suppl 2:512-5.  9172579  
Wei S, Tanaka H, Kubo T, Ono T, Kanzaki S, Seino Y. Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency. Eur J Endocrinol. 1997 Jan;136(1):45-51.  9037126 
Wei S, Tanaka H, Kubo T, Ichikawa M, Seino Y. A multiple assay for vitamin D metabolites without high-performance liquid chromatography. Anal Biochem. 1994 Nov 1;222(2):359-65.  7864359 
Bai S, Wei S, Pasha TL, Yao Y, Tomaszewski JE, Bing Z. Immunohistochemical studies of metastatic germ-cell tumors in retroperitoneal dissection specimens: a sensitive and specific panel. Int J Surg Pathol. 2013 Aug;21(4):342-51. doi: 10.1177/1066896912471849.  23893437 
Bai S, Wei S, Ziober A, Yao Y, Bing Z. Expression of SALL4 and SF-1 in gonadoblastoma: useful markers in the identification of the invasive germ cell component. Int J Gynecol Pathol. 2013 Jul;32(4):379-83. doi: 10.1097/PGP.0b013e31826a62ee.  23722510 
Bai S, Nunez AL, Wei S, Ziober A, Yao Y, Tomaszewski JE, Bing Z. Microsatellite Instability and TARBP2 Mutation Study in Upper Urinary Tract Urothelial Carcinoma. Am J Clin Pathol. 2013 Jun;139(6):765-70. doi: 10.1309/AJCPBSLP8XHSWLOW.  23690119  
Kragel CP, Siegal GP, Wei S. Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. Am J Orthop. 2013 Apr;42(4):175-8.  23630677 
Hussain HM, Little MD, Wei S. AIRP Best Cases in Radiologic-Pathologic Correlation: Gallbladder Carcinoma with Direct Invasion of the Liver. Radiographics. 2013 Jan-Feb;33(1):103-8. doi: 10.1148/rg.331115163.  23322830 
Xu J, Latif S, Wei S. Metastatic renal cell carcinoma presenting as gastric polyps: A case report and review of the literature. Int J Surg Case Rep. 2012 Aug 24;3(12):601-604. doi: 10.1016/j.ijscr.2012.08.009. [Epub ahead of print]  22989776 
Bai S, Wei S, Ziober A, Yao Y, Bing Z. Sall4 and SF-1 are sensitive and specific markers in distinguishing granulosa cell tumors from yolk sac tumors. Int J Surg Pathol. 2013 Apr;21(2):121-5. doi: 10.1177/1066896912454567. Epub 2012 Jul 25.  22832114  
Jules J, Ashley JW, Zhang P, Wei S, Shi Z, Liu J, Michalek SM, and Feng X. Molecular Basis of the Requirement of RANK Signaling for Interleukin-1 (IL-1)-mediated Osteoclastogenesis. J Biol Chem 2012 May 4;287(19):15728-38. Epub 2012 Mar 13.  22416138 
Nunez A, Siegal GP, Reddy V, Wei S. CD138 (Syndecan-1) expression in bone-forming tumors. Am J Clin Pathol. 2012 Mar;137(3):423-8. doi: 10.1309/AJCP6V4YPFBOCYXG.  22338054 
Pan Z, Sanger WG, Bridge JA, Hunter WJ, Siegal GP, Wei S. A Novel t(6;13)(q15;q34) Translocation in a Giant Cell Reparative Granuloma (Solid Aneurysmal Bone Cyst). Hum Pathol. 2012 Jun;43(6):952-7. Epub 2012 Jan 26.  22285042 
Pan Z, Bland KI, Wei S. Composite Cutaneous Langerhans Cell Histiocytosis and Atypical Vascular Lesion After Radiation for Breast Carcinoma: Can Radiation Induce Langerhans Cell Histiocytosis? Dermatol Online J. 2011 Dec 15;17(12):6.  22233742 
Wei S, Kragel C, Zhang K, Hameed O. Factors Associated with Residual Disease after Initial Breast-Conserving Surgery for Ductal Carcinoma in Situ. Hum Pathol. 2012 Jul;43(7):986-93. Epub 2012 Jan 4.  22221704  
Wei S, Siegal GP. A 23-year-old Woman with a Right Femoral Neck Fracture. JAMA. 2011 Dec 7;306(21):2385-6. doi: 10.1001/jama.2011.1748.  22147386 
Cheng J, Liu J, Xu D, Luo S, Wei S, Feng X. Molecular mechanisms of the biphasic effects of interferon gamma on osteoclastogenesis. J Interferon Cytokine Res. J Interferon Cytokine Res. 2012 Jan;32(1):34-45. doi: 10.1089/jir.2011.0019. Epub 2011 Dec 5.   22142221 
Bai S, Jhala N, Adsay NV, Wei S. Sclerosing Epithelioid Fibrosarcoma of the Pancreas: Report of a Case and Review of Literature with Emphasis on the Differential Diagnosis. Ann Diagn Pathol. 2013 Apr;17(2):214-6. doi: 10.1016/j.anndiagpath.2011.06.006. Epub 2011 Nov 4.  22056035 
Abdel-Aal AK, Gaddikeri S, Saddekni S, Oser RF, Underwood E, Wei S. Primary Leiomyosarcoma of the Inferior Vena Cava Invading the Right Atrium: A Technique for Intraluminal Biopsy Through a Transvenous Approach. Vasc Endovascular Surg. 2011 Nov;45(8):743-6. Epub 2011 Sep 13.  21914679 
Cheng J, Liu J, Shi Z, Xu D, Luo S, Feng X, Siegal GP and Wei S. Interleukin-4 Inhibits RANKL-induced NFATc1 Expression via STAT6: A Novel Mechanism Mediating Its Blockade of Osteoclastogenesis. J Cell Biochem. 2011 Nov;112(11):3385-92. doi: 10.1002/jcb.23269.  21751242 
Wei S, Pan Z, Siegal GP, Winokur TS, Carroll AJ, Jhala D. Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts. Hum Pathol. 2012 Jan;43(1):121-6. Epub 2011 Jul 5.  21733556 
Nguyen TL, Grizzle WE, Zhang K, Hameed O, Siegal GP, Wei S. Syndecan-1 Overexpression is Associated with Non-luminal Subtypes and Poor Prognosis in Advanced Breast Cancer. Am J Clin Pathol. 2013 Oct;140(4):468-74. doi: 10.1309/AJCPZ1D8CALHDXCJ.  24045542 
Kragel C, Wei S. Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report. J Med Case Reports. 2011 Jun 29;5(1):248.  21714864 
Wei S, Li Y, Siegal GP, Hameed O. Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs. Ann Diagn Pathol. 2011 Apr;15(2):79-83. Epub 2010 Dec 16.  21163679 
Wei S, Conner MG, Zhang K, Siegal GP, Novak L. Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance. Int J Gynecol Pathol. 2010 Nov;29(6):562-7.  20881855 
Wei S, Said-Al-Naief N, Hameed O. Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas: A Tissue Microarray and Pooled Literature Review Study. Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):393-402.  19417624 
Wei S, Carroll W, Lazenby A, Bell W, Lopez R, Said-Al-Naief N. Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome. Ann Diagn Pathol. 2008 Dec;12(6):415-25. Epub 2007 Oct 24.  18995206  
Wei S, Siegal GP. Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets. Pathol Res Pract. 2008;204(10):695-706. Epub 2008 Aug 30.  18757139  
Wei S, Siegal GP. p38 MAPK as a potential therapeutic target for inflammatory osteolysis. Adv Anat Pathol. 2007 Jan;14(1):42-5.  17198310  
Liu W, Wang S, Wei S, Sun L, Feng X. Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4. Liu W, Wang S, Wei S, Sun L, Feng X. J Biol Chem. 2005 Dec 30;280(52):43064-72. Epub 2005 Oct 31.  16260781  
Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005 Feb;115(2):282-90.  15668736 
Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Ross FP, Teitelbaum SL. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol. 2004 Oct 15;173(8):4838-46.  15470024  
Wang MW, Wei S, Faccio R, Takeshita S, Tebas P, Powderly WG, Teitelbaum SL, Ross FP. The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J Clin Invest. 2004 Jul;114(2):206-13.  15254587  
Feng X, Takeshita S, Namba N, Wei S, Teitelbaum SL, Ross FP. Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function. Endocrinology. 2002 Dec;143(12):4868-74.   12446614  
Wei S, Wang MW, Teitelbaum SL, Ross FP. Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem. 2002 Feb 22;277(8):6622-30. Epub 2001 Nov 21.  11719504 
Wei S, Teitelbaum SL, Wang MW, Ross FP. Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursors. Endocrinology. 2001 Mar;142(3):1290-5.  11181547  
Xu J, Wei S. Breast Implant-associated Anaplastic Large Cell Lymphoma: Review of a Distinct Clinicopatholgical Entity. Arch Pathol Lab Med. In press.   
Inoue M, Ross FP, Erdmann JM, Abu-Amer Y, Wei S, Teitelbaum SL. Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology. 2000 Jan;141(1):284-90.  10614649 
Eleazer PD, Rhodes SC, Horn DM, DeVilliers P, Wei S, Novak L, Dohm ED, Weems RA, Litaker MS. In Vivo Evaluation of an Experimental Root-End Filling Material versus MTA. Open Journal of Animal Sciences. 2013 Jul;3A:19-23. doi: 10.4236/ojas.2013.33A003.   
Wei S, Siegal GP. Atlas of Bone Pathology. Springer. 2013.   
Jhala KN, Wei S, Lopez-Ben RR, Siegal GP. Bizarre Parosteal Osteochondromatous Proliferation-like Lesion Originating in Soft Tissue: Report of a Case. Open Journal of Pathology 2012 Apr;(2)2:38-41. DOI: 10.4236/ojpathology.2012.22008.   
Hameed O, Wei S, Siegal GP. Frozen Section Library: Bone. Springer. 2011.   
Wei S, Hameed O. Spindle Cell Lesions of the Breast with Emphasis on the Differential Diagnosis. The Open Breast Cancer Journal. http://www.bentham.org/open/tobcanj/openaccess2.htm. 2010 Pp 95-100.   
Wei S, Siegal GP. Targeting p38 MAPK for the treatment of inflammatory arthritis. Future Rheumatology. 2008;3(1):37-42.