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Faculty Detail    
Name WILLIAM E GRIZZLE
Professor of Pathology
Head, Pathology Program for Translational Research in Neoplasia
Director, Tissue Collection and Banking Facility
Senior Scientist, UAB Comprehensive Cancer Center, Center for Aging, Metabolic Bone Disease Research Center, Cystic Fibrosis Center
Senior Editor, Clinical Cancer Research
 
Campus Address ZRB 426 Zip 0007
Phone  205-934-4214
E-mail  wgrizzle@uab.edu
Other websites
     

Education
Undergraduate  Harvard University    1965  A.B. Chemistry and Physics 
Graduate  Johns Hopkins University    1975  Ph.D. in Biophysics 
Medical School  Johns Hopkins University School of Medicine    1977  M.D. 
Graduate  Georgetown University    ABD  MS In Physics 

Certifications
American Board of Pathology, Anatomical and Clinical, Diplomate  1982 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Professor
Center  General Clinical Research Center  Center for Outcomes & Effectiveness Res & Educ Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Medicine  Ctr Cardiovasc Bio (Org Ret) Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Molecular and Cellular Pathology Program 

Biographical Sketch 
From 1965-1970, I served in the US Navy, Division of Naval Reactors and the Atomic Energy Commission. Since 1981, I have been on the faculty of the University of Alabama at Birmingham (UAB) with a primary appointment in the Department of Pathology. In 2000, I was selected to join the UAB Comprehensive Cancer Center.

Society Memberships
Organization Name Position Held Org Link
Alabama Society for Histotechnology (ASH)  Honorary  http://www.alhistology.org/ 
American Association for Cancer Research (AACR)  Senior Editor, Clinical Cancer Research  http://www.aacr.org/ 
Biological Stain Commission (BSC)  Trustee, Past Vice-President, Past President  http://www.biologicalstaincommission.org/ 
College of American Pathologists (CAP)  Past Elected Member  http://www.cap.org/apps/cap.portal 
Endocrine Society  Past Elected Member  https://www.endocrine.org/ 
International Society for Biological and Environmental Repositories (ISBER)  Past President, Member of Publications Committee, Science Policy Committee, Informed Consent Working Group, Hospital Integrated Biorepositories (HIB) Working Group  http://www.isber.org/ 

Research/Clinical Interest
Title
Biomarkers in Early Detection, Prognosis, Risk and Therapeutic Outcome; Anatomic and Clinical Pathology; Tissue Resources to Support Biomedical Research; Immunomodulation of Cancer; Aging and Cancer; Post-transcriptional Processing of Genetic Info
Description
One area in which our laboratory works is to increase the understanding of molecular features of epithelial cancers such as prostate, pancreas, mammary, colorectal and ovarian adenocarcinomas as well as squamous cell lesions of oral cavity, esophagus, lung, cervix and skin. Our goal is to identify biomarkers associated either with early pre-invasive neoplastic lesions or with advanced stage malignant lesions, especially metastatic lesions. Of special interest are biomarkers that can be used to aid in determining prognosis or risk assessment or in predicting successful therapy. Of great interest are collaborative efforts to improve the biomathematic/statistical approaches to evaluating biomarkers and multiplex methods of analysis and how bias in collecting and processing tissue samples may affect multiplex assays.We have reported molecules that are differentially expressed in prostatic intraepithelial neoplasia (PIN), ductal carcinoma of the breast (DCIS), and adenomatous polyps of the colorectum (CRC) and have identified multiple biomarkers associated with the prognosis of the CRC and breast cancer. In addition, we have evaluated racial differences in biomarkers which is a major focus of our research. Besides our interests in epithelial neoplasia, we have a broad interest in diffuse pulmonary diseases including pulmonary arterial hypertension and cystic fibrosis related changes as well as tissue reparative processes leading to granulation tissues and neovascularity. In general our laboratory utilizes proteomic techniques but also has capabilities in molecular biology. In addition to semi-quantitative immunohistochemistry (fluorescent or bright field), Western blotting, high throughput ELISA, multiplex immunoassays (Luminex). We collaborate using other mass spectrometry systems in the early detection of cancers by determining the proteins of specific cancers in biological fluids such as serum. We also have automated cytomorphometric instrumentation and tissue arrays that can be used in multi-tissue analyses. Similarly, we can use gene chip and spotted array analysis in gene discovery. Thus, our studies focus on molecular epidemiology of neoplasia. Also, for the last three decades we have provided human tissues to support the research of biomedical investigators throughout North America. In this effort, sponsored primarily by the Cooperative Human Tissue Network (CHTN), we have introduced to tissue resources the utilization of quality control of tissues provided for research and we have been involved in database development for tissue resources. We also have great expertise in how fixation of tissues interacts with the stages of tissue processing to affect immunorecognition and other molecular assays. New interests include characterizations of the molecules involved in mitosis, especially proteins of the centriole and centrosome, post-transcriptional processing (e.g., microRNA and IRES), exosomes, and genes controlling metastasis (e.g., KISS).

Selected Publications 
Publication PUBMEDID
Srivastava SK, Bhardwaj A, Singh S, Arora S, McClellan S, Grizzle WE, Reeed E, Singh AP. Mb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. Carcinogenesis 2012;33(6):1149-57  3514863 
Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S. CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic cancer cells via ERK- and Akt- mediated activation of NF=kB: implications for bidirectional tumor-stromal interactions. J Biological Chem 2012;287(46):39115-24  3493952 
Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakratory SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora Kinase-A inactivates DNA damage induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 2012;21(2):196-211  22340593 
Wang H, Jones J, Turner T, He QP, Hardy S, Grizzle WE, Welch DR, Yates C. Clinical and biological significance of KISS1 expression in prostate cancer. Am J Pathol 2012;180(3):1170-8  22226740 
Bovell L, Shanmugam C, Katkoori VR, Zhang B, Vogtmann E, Grizzle WE, Manne U. miRNAs are stable in colorectal cancer archival tissue blocks. Front Biosci (Elite Ed) 2012;4:1937-40  22202009 
Deng Z, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W, Mobley J, Roman J, Miller D, Zhang HG. Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression. Am J Pathol 2012;180(1):390-398  22067905 
Srivastava SK, Bhardwaj A, Singh S, Arora S, Wang B, Grizzle WE, Singh AP. MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis 2011;12:1832-9  21983127 
Zhang H-G, Grizzle WE. Exosomes and Cancer: A newly described pathway of immune suppression. Clin Can Res. 2011;17(5):959-64  21224375 
Brand RE, Nolen BM, Zeh HJ, Allen PJ, Grizzle WE, Lookshin AE. Serum biomarker panels for the detection of pancreatic cancer. Clin Can Res 2011;17(4):805-16  21193998 
McNally LR, Welch DR, Beck BH, Stafford LJ, Long JW, Sellers JC, Huang ZQ, Grizzle WE, Stockard CR, Nash KT, Buchsbaum DJ. KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model. Clin Exp Metastasis 2010 Dec;27(8):591-600.  20844932 
Blume SW, Jackson NL, Frost AR, Grizzle WE, Shcherbakov OD, Choi H, Meng Z. Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES. Exp. Mol. Pathol. 2010; 88(3):341-52.  20233590 
Katkoori V, Jia X, Shanmugam C, Wan W, Meleth S, Bumpers H, Grizzle W, Manne U, Prognostic Significance of p53 Codon 72 Polymorphism Differs with Race in Colorectal Adenocarcinoma. Clin Cancer Res. 2009;15(7):2406-16  19339276 
Alder MN, Herrin BR, Sadlonova A, Stockard CR, Grizzle WE, Gartland LA, Gartland GL, Boydston JA, Turnbough CL Jr, Cooper MD. Antibody responses of variable lymphocyte receptors in the lamprey. Nat Immunol. 2008;9(3):319-27  18246071 
Chakrabarti R, Jones JL, Oelschlager DK, Ta pia T, Tousson A, Grizzle WE. Phosphorylated LIM Kinases Colocalize with Gamma-Tubulin in Centrosomes During Early Stages of Mitosis. Cell Cycle. 2007;6(23):2944-52  18000399 
Grizzle WE, Bell WC, Sexton KC. Issues in collecting, processing and storing human tissues and associated information to support biomedical research. In: Translational Pathology of Early Cancer. (Eds. S Srivastava, WE Grizzle), IOS Press BV, Amsterdam, The Netherlands; 2012;531-549.   
Gurpinar E, Grizzle WE, Shacka JJ, Mader B, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA. A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Molecular Cancer Ther 2013;12(5):63-74.  3651802  
Kerr EH, Frederick PJ, Egger ME, Stockard CR, Sellers J, DellaManna D, Oelschlager D, Amm HM, Eltoum IE, Straughn JM, Buchsbaum DJ, Grizzle WE, McNally LR. Lung resistance-related protein (LRP) expression in malignant ascetic cells as a prognostic marker for advanced ovarian serous carcinoma. Annals of Surgical Oncology PLoS ONE 2013;8(1):354473. doi: 10.1371/journal.pone.0054473. Epub 2013 Jan 23  3553101 
Grizzle WE, Srivastava S, Manne U. Translational Pathology of Cancer. In: Translational Pathology of Early Cancer. (Eds. S. Srivastava, WE Grizzle) IOS Press BV, Amsterdam, The Netherlands. 2012;7-20   

Keywords
epithelial cancers, proteomics, biomarkers, early detection, prognosis, molecular staging, immune modulation, post-transcriptional processing, microRNA, metastases, extracellular vesicles, exosomes, centrosomal & centriolar proteins, biorepositories