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Faculty Detail    
Name LIONEL C CLEMENT
 
Campus Address THT 616 Zip 0007
Phone 205-975-5125
E-mail lclement@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Assistant Professor

Biographical Sketch 
Dr. Clément received his PhD in Nutrition Physiology from the University of Burgundy in Dijon, France, in 2004. In December 2004, he joined Dr. Chugh’s laboratory in the division of Nephrology at Northwestern University Feinberg school of Medicine in Chicago as a Postdoctoral Fellow. Then he moved to the Division of Nephrology at the University of Alabama at Birmingham in August 2007. He was promoted to Instructor in September 2010, then to Assistant Professor in July 2012.

Society Memberships
Organization Name Position Held Org Link
American Heart Association  Member   
American Society of Nephrology  Member   

Research/Clinical Interest
Title
Role of Angiopoietin-like-4 (Angptl4) in the development of hypertriglyceridemia in nephrotic syndrome.
Description
Dr. Clément research interests are focused on glomerular diseases. He conducts studies on two major projects: understanding the biological role of the Zinc Finger and Homeobox (Zhx) family of proteins in the development of podocyte disease and nephrotic syndrome (Clement et al, JBC, 2006; Clement et al, Kidney International, 2007), and the study of the role of Angiopoietin-like-4 (angptl4) in the development of proteinuria and nephrotic syndrome (Clement et al, Nature Medicine, 2011). He presently investigates the potential role of podocyte-secreted Angptl4 in the development of hypertriglyceridemia in nephrotic syndrome.

Selected Publications 
Publication PUBMEDID
Chugh SS, Clement LC.Telomerase at the center of collapsing glomerulopathy. Nat Med. 2012 Jan 6; 18(1):26-7.  22227662 
Chugh SS, Clement LC, Macé C. New insights into human minimal change disease: Lessons from animal models. Am J Kid Dis. 2012 Feb; 59(2):284-92. Epub 2011 Oct 5. Review.  21974967 
Tran TT, Poirier H, Clement L, Nassir F, Pelsers MM, Petit V, Degrace P, Monnot MC, Glatz JF, Abumrad NA, Besnard P, Niot I. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 2011 Jul15; 286(28):25201-10. Epub 2011 May 24.  21610069 
Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S and Chugh SS. Podocyte – secreted Angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 2011; 17: 117-122.  21151138 
Clement L, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C and Chugh SS. Early changes in gene expression that influence the course of primary glomerular disease. Kidney Int. 2007;72:337-347.  17457373 
Liu G*, Clement L* (* equal authors), Kanwar YS, Avila-Casado C and Chugh SS. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J Biol Chem 2006, 281;39681-39692.  17056598 
Poirier H, Rouault C, Clement L, Niot I, Monnot M-C, Guerre-Millo M, and Besnard P. Hyperinsulinaemia tiggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia. 2005 Jun;48(6):1059-65.  15868135 
Poirier H, Niot I, Clement L, Guerre-Millo M, and Besnard P. Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse. Biochimie. 2005 Jan;87(1):73-9. Review.  15733740 
Drozdowski L, Clement L, Keelan M, Niot I, Clandinin MT, Agellon L, Wild G, Besnard P, and Thomson AB. Dietary lipids modify intestinal lipid-binding protein RNA abundance in diabetic and control rats. Digestion. 2004;70(3):192-8.  15627765 
Bellenger J, Bellenger S, Clement L, Mandard S, Diot C, Poisson J-P, and Narce M. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl-CoA desaturase-1 gene expression in the SHR model of genetic hypertension. FASEB J. 2004 Apr;18(6):773-5.  14977874 
Besnard P, Niot I, Poirier H, Clement L, and Bernard A. New insights into the fatty acid-binding protein (FABP) family in the small intestine. Mol Cell Biochem. 2002 Oct;239(1-2):139-47. Review.  12479579 
Clement L, Poirier H, Niot I, Bocher V, Guerre-millo M, Krief S, Staels B, and Besnard P. Dietary trans-10,cis-12 conjugated linoleic acid triggers hyperinsulinaemia and fatty liver in the mouse. J Lipid Res. 2002 Sep;43(9):1400-9.  12235171 

Keywords
Nephrotic syndrome, podocyte, minimal change disease, hypertriglyceridemia.