Back to Main

Faculty Detail    
Name BRUCE A JULIAN
 
Campus Address THT 643 Zip 0006
Phone 205-934-9045
E-mail bjulian@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Professor Emeritus

Biographical Sketch 
Bruce A. Julian, MD is Professor of Medicine in the Division of Nephrology and Professor of Surgery in the Division of Transplantation. He graduated from Wabash College and received his MD degree from Washington University in St. Louis, MO. His clinical training in internal medicine and nephrology was completed at the University of Kentucky, Lexington. After four years in private practice in Lexington, KY, he joined the faculty at UAB in 1984.

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology     
National Kidney Foundation     

Research/Clinical Interest
Title
IgA nephropathy, recurrent disease in renal allografts, erythropoiesis after renal transplantation
Description
Dr. Julian's primary research interest is IgA nephropathy. The studies investigate the clinical expression and natural history of the disease, identification of the gene in multiplex families, and recurrence after kidney transplantation. He also collaborates with Dr. J Mestecky and colleagues in the Department of Microbiology and Dr. Robert J Wyatt at the University of Tennessee in Memphis in projects to clarify the nephritogenic nature of galactose-deficient IgA1 in patients with IgA nephropathy and Henoch-Schoenlein purpura nephritis. Other areas of interest include post-transplant erythrocytosis, and the role suppression of angiotensin II, by angiotensin converting enzyme inhibitors or angiotensin receptor type 1 blockers, in its treatment. He also interacts with members of the liver transplant team in studies to clarify the impact of glomerulonephritis after hepatic engraftment in patients with hepatitis C-induced cirrhosis.

Selected Publications 
Publication PUBMEDID
Mrug M, Stopka T, Julian BA, Prchal JF, Prchal JT: Angiotensin II stimulates proliferation of normal early erythroid progenitors. J Clin Invest 100:2310-2314,1997.  9410909 
Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ: Familial IgA nephropathy: evidence for an inherited mechanism of disease. N Engl J Med 312:202-208,1985.  3855328 
Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, Wyatt RJ, Scolari F, Mestecky J, Gharavi AG, Julian BA: The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22:1795-803,2011.  21949093 
Takahashi K, Wall SB, Suzuki H, Smith AD, Hall S, Paulsen K, Kilian M, Mobley JA, Julian BA, Mestecky J, Novak J, Renfrow MB: Clustered O-glycans of IgA1: Defining macro- and micro-heterogeneity by use of electron capture/transfer dissociation. Mol Cell Proteomics 9:2545-2557,2010.  20823119 
Cattran D, Coppo R, Cook T, Feehally J, Roberts IS, Troyanov S, Alpers CE, Barratt J, Berthoux F, Bonsib S, Bruijn JA, D’Agati V, D’Amico G, Camilla R, Emancipator S, Emma F, Ferrario F, Fervenza FC, Florquin S, Fogo A, Geddes CC, Groene H, Haas M, Herzenberg AM, Hill P, Hogg RJ, Hsu S, Jennett JC, Joh K, Julian BA, Kawamura T, Lai F, Li L, Li P, Liu Z, Mezzano S, Schena FP, Tomino Y, Walker P, Wang H, Weening JJ, Yoshikawa N, Zhang H: The Oxford classification of IgA nephropathy: Part 1: Rationale, clinicopathological correlations, and proposal for classification. Kidney Int 76:534-545,2009.  19571791 
Kumar V, Julian BA, Deierhoi MH, Curtis JJ: Secondary listing for deceased-donor kidney transplantation does not increase likelihood of engraftment at a large transplant center. Am J Transplant 9:1671-1673,2009.   19519825 
Suzuki, H., Fun, R., Zhang, Z., Brown, R., Hall, S., Julian, B.A., Chatham, W.W., Suzuki, Y., Wyatt, R.J., Moldoveanu, Z., Lee, J.Y., Robinson, J., Tomana, M., Tomino, Y., Mestecky, J., Novak, J. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest 119:1668-1677,2009.  19478457 
Gharavi AG, Yan Y, Scolari F, Schena FP, Frasca GM, Giggheri GM, Cooper K, Amoroso A, Viola BF, Battin VG, Caridi G, Canova C, Farhi A, Subramanian V, Woodford S, Julian BA, Wyatt RJ, Lifton RP: IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nature Genet 26:354-357,2000.  18272841 
Suzuki, H., Moldoveanu, Z., Hall, S., Brown, R., Vu, H.L., Novak, L., Julian, B.A., Tomana, M., Wyatt, R.J., Edberg, J.E., Alarcón, G.S., Kimberly, R.P., Tomino, Y., Mestecky, J., Novak, J. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest 118:629-639,2008.  18172551 
Julian BA, Wittke S, Novak J, Good DM, Coon JJ, Kellmann M, Zurbig P, Schiffer E, Haubitz M, Moldoveanu Z, Calcatera SM, Wyatt RJ, Sykora J, Sladkova E, Hes O, Mischak H, McGuire BM: Electrophoretic methods for analysis of urinary polypeptides in IgA associated renal diseases. Electrophoresis 28:4469-4483,2007.  18004714 
Renfrow MB, MacKay CL, Chalmers MJ, Julian BA, Mestecky J, Kilian M, Poulsen K, Emmett MR, Marshall AG, Novak J: Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by fourier transform ion cyclotron resonance mass spectrometry: Implications for IgA nephropathy. Anal Bioanal Chem 389:1397-1407,2007.  1771255 
McGuire BM, Julian BA, Bynon JS, Cook WJ, King SJ, Curtis JJ, Accortt NA, Eckhoff DE. Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation. Ann Intern Med 144:735-741,2006.  16702589 

Keywords
IgA nephropathy, kidney transplantation, erythropoiesis, glomerulonephritis