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Faculty Detail    
Name ROSLYN B. MANNON
 
Campus Address THT 611G Zip 0007
Phone 205-934-7220
E-mail rmannon@uab.edu
Other websites
     

Education
Undergraduate  The Johns Hopkins University     1981  BA 
Medical School  Duke University    1985  MD 
Residency  Duke University    1988  Internal Medicine 
Fellowship  Duke University    1991  Nephrology 
Residency  Duke University    1991  Chief Resident, Internal Medicine 

Certifications
Internal Medicine  1988 
Nephrology  2012 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Professor
Secondary  Surgery   Surgery Chair Office Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations
Immunology 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Mannon received her medical degree from Duke University Medical School in Durham, North Carolina. She completed her internship and residency in Internal Medicine, and Nephrology fellowship as well as serving as Chief Resident in the Department of Medicine, also at Duke. After several years on Duke Nephrology faculty as an NIH-funded investigator in transplant immunology at the rank of Assistant Professor and Director of Transplantation at the Durham VA Medical Center, she joined the Transplantation Branch of NIDDK at the National Institutes of Health Clinical Center, an intramural, translational research program in transplantation immunology. As Medical Director of Transplantation for the program that performed over 160 kidney and kidney/pancreas transplants all under protocol defined care, Dr. Mannon provided clinical and protocol support as well as maintained an active laboratory effort. She also served on the faculty of Uniformed Services University of the Health Sciences in Bethesda as Associate Professor and later Professor of Medicine. Dr. Mannon is board certified in Internal Medicine and Nephrology. She joined the UAB faculty in August 2008.

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology  Member, Education Committee  http://www.asn-online.org/ 
American Society of Transplantation  Chair, Governance Committee   
American Society of Transplantation  Chair, Public Policy Committee   
American Society of Transplantation  Immediate Past President  http://www.a-s-t.org/ 

Research/Clinical Interest
Title
Translational Approaches to the Pathogenesis and Treatment of Chronic Graft Injury
Description
Despite dramatic improvements in acute rejection rates and short term graft survival, long term graft loss remains a significant problem after kidney transplantation. The leading cause of late graft loss is due to interstitial fibrosis (IF) and tubular atrophy (TA), an entity previously called chronic allograft nephropathy (CAN). IF/TA can occur months to years after transplantation, and is manifested by a progressive decline in graft function, protein in the urine, and hypertension. The etiology of this disorder is multifactorial and includes both immunologic and non-immunologic etiologies. Moreover, there are no specific therapies for IF/TA beyond controlling blood pressure and cholesterol levels, similar to other forms of kidney failure. Our research program utilizes a series of rodent models of kidney and heart transplantation and calcineurin inhibitor toxicity to study the cellular, molecular, and physiologic events following transplantation. By manipulating the donor and recipient combinations, we have found that recipient and donor matching can alter graft the course of IF/TA. Utilizing these models, we have analyzed for gene and protein expression in diseased kidneys. We have used these models as platforms for translation into our human patients following kidney transplantation. Our long term goal is to identify new mechanisms and associated biomarkers in the detection and treatment of IF/TA.

Selected Publications 
Publication PUBMEDID
A Case of Late Kidney Allograft Failure: A Clinical Pathological Conference from American Society of Nephrology Kidney Week 2011.
Randhawa P, Mannon RB.

 
2859745 
A reproducible mouse model of chronic allograft nephropathy with vasculopathy.
Zarjou A, Guo L, Sanders PW, Mannon RB, Agarwal A, George JF
 
22874842 
Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: results from a kidney transplant consortium.
Jacobson PA, Schladt D, Israni A, Oetting WS, Lin YC, Leduc R, Guan W, Lamba V, Matas AJ; DeKAF Investigators.

 
22334041 
Macrophages: contributors to allograft dysfunction, repair, or innocent bystanders?
Mannon RB.

 
22157320 
Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.
Sam WJ, Chamberlain CE, Lee SJ, Goldstein JA, Hale DA, Mannon RB, Kirk AD, Hon YY.
Transplantation. 2011 Dec 27;92(12):1342-7.

 
22094953 
Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection.
Srivastava M, Eidelman O, Torosyan Y, Jozwik C, Mannon RB, Pollard HB.
Proteomics Clin Appl. 2011 Jun;5(5-6):311-21. 
21591265 
Chemokines and their receptors in human renal allotransplantation.
Lo DJ, Weaver TA, Kleiner DE, Mannon RB, Jacobson LM, Becker BN, Swanson SJ, Hale DA, Kirk AD.
Transplantation. 2011 Jan 15;91(1):70-7.
 
21441854 
Optimal cutoff point for immunoperoxidase detection of C4d in the renal allograft: results from a multicenter study.
Crary GS, Raissian Y, Gaston RC, Gourishankar SM, Leduc RE, Mannon RB, Matas AJ, Grande JP.
Transplantation. 2010 Nov 27;90(10):1099-105.
 
21430605 
Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure.
Mannon RB, Matas AJ, Grande J, Leduc R, Connett J, Kasiske B, Cecka JM, Gaston RS, Cosio F, Gourishankar S, Halloran PF, Hunsicker L, Rush D; DeKAF Investigators.
Am J Transplant. 2010 Sep;10(9):2066-73. doi: 10.1111/j.1600-6143.2010.03240.x.
 
20883541 
Low-density array PCR analysis of reperfusion biopsies: an adjunct to histological analysis.Cravedi P, Maggiore U, Mannon RB. Nephrol Dial Transplant. 2010 May 26
 
20504838 
Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure. Gaston RS, Cecka JM, Kasiske BL, Fieberg AM, Leduc R, Cosio FC, Gourishankar S, Grande J, Halloran P, Hunsicker L, Mannon R, Rush D, Matas AJ. Transplantation. 2010 Jul 15;90(1):68-74.
 
20463643 
Noninvasive methods to assess the risk of kidney transplant rejection.Cravedi P, Mannon RB. Expert Rev Clin Immunol. 2009 Sep 1;5(5):535-546.
 
20161000 
Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups.Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K, Baldwin WM 3rd, Bracamonte ER, Broecker V, Cosio F, Demetris AJ, Drachenberg C, Einecke G, Gloor J, Glotz D, Kraus E, Legendre C, Liapis H, Mannon RB, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Rodriguez ER, Seron D, Seshan S, Suthanthiran M, Wasowska BA, Zachary A, Zeevi A. Am J Transplant. 2010 Mar;10(3):464-71.  20121738 
Pathological and clinical characterization of the 'troubled transplant': data from the DeKAF study. Gourishankar S, Leduc R, Connett J, Cecka JM, Cosio F, Fieberg A, Gaston R, Halloran P, Hunsicker L, Kasiske B, Rush D, Grande J, Mannon R, Matas A. Am J Transplant. 2010 Feb;10(2):324-30.
 
20055809  
Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CAN or CR: preliminary data from the DeKAF study.

Matas AJ, Leduc R, Rush D, Cecka JM, Connett J, Fieberg A, Halloran P, Hunsicker L, Cosio F, Grande J, Mannon R, Gourishankar S, Gaston R, Kasiske B. Am J Transplant. 2010 Feb;10(2):315-23.
 
20041864 
Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potientially at risk for adverse events. Hon YY, Chamberlain CE, Kleiner DE, Ring MS, Hale DA, Kirk AD, Mannon RB. Clin Transplant. 2009 Nov 18.
 
19925470  
What's New, What's Hot in Solid Organ Transplantation? Summary of the American Transplant Congress 2011.
Karp SJ, Mannon RB.
Am J Transplant. 2011 Nov;11(11):2308-16.
 
1967066 
Chamberlain CE, Penzak SR, Alfaro RM, Wesley R, Daniels CE, Hale D, Kirk AD, Mannon RB.
Pharmacokinetics of low and maintenance dose valganciclovir in kidney transplant recipients.
Am J Transplant. 2008 Jun;8(6):1297-302.  
18444933 
Jevnikar AM, Mannon RB.
Late kidney allograft loss: what we know about it, and what we can do about it.
Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2:S56-67. Review.
 
18309004 
Elster EA, Leeser DB, Morrissette C, Pepek JM, Quiko A, Hale DA, Chamberlain C, Salaita C, Kirk AD, Mannon RB.
Obesity following kidney transplantation and steroid avoidance immunosuppression.
Clin Transplant. 2008 May-Jun;22(3):354-9. Epub 2008 Feb 13.
 
18279417 
Kirk AD, Hale DA, Ford E, Kleiner DE, Kampen RL, Elster EA, Swanson SJ, Cendales LC, Cropper T, Hale L, Jordan S, Koussis T, Peretti J, Sloane A, Salaita C, Ring M, Chamberlain C, Mannon RB.
Solid organ transplantation at the National Institutes of Health: development of a research-based transplantation practice.
Clin Transpl. 2005:131-44.
 
17424731 
Cheng O, Thuillier R, Sampson E, Schultz G, Ruiz P, Zhang X, Yuen PS, Mannon RB.
Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis.
Am J Transplant. 2006 Oct;6(10):2292-306.  
16889607 
Mannon RB.
Therapeutic targets in the treatment of allograft fibrosis.
Am J Transplant. 2006 May;6(5 Pt 1):867-75. 
16611322 
Xu H, Zhang X, Mannon RB, Kirk AD.
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154.
J Clin Invest. 2006 Mar;116(3):769-74. 
16498500 
Mannon RB, Hoffmann SC, Kampen RL, Cheng OC, Kleiner DE, Ryschkewitsch C, Curfman B, Major E, Hale DA, Kirk AD.
Molecular evaluation of BK polyomavirus nephropathy.
Am J Transplant. 2005 Dec;5(12):2883-93. 
16303001 
Kirk AD, Hale DA, Mannon RB, Kleiner DE, Hoffmann SC, Kampen RL, Cendales LK, Tadaki DK, Harlan DM, Swanson SJ.
Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).Transplantation. 2003 Jul 15;76(1):120-9.
 
12865797  
Franceschini N, Cheng O, Zhang X, Ruiz P, Mannon RB.
Inhibition of prolyl-4-hydroxylase ameliorates chronic rejection of mouse kidney allografts.
Am J Transplant. 2003 Apr;3(4):396-402.
 
12694061 

Keywords
kidney transplant, fibrosis, rejection, graft survival, growth factors, genetic