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Faculty Detail    
Name ASHITA J TOLWANI
 
Campus Address ZRB 604
Phone  205-975-2021
E-mail  atolwani@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor

Biographical Sketch 
EDUCATION:
Harvard School of Public Health, Masters of Science in Epidemiology, 7/01-6/04
University of Alabama at Birmingham, Nephrology Fellowship, 7/97 - 6/99
University of Alabama at Birmingham, Internal Medicine Residency, 7/94 - 6/97
University of Alabama at Birmingham School of Medicine, M.D., 7/90 - 6/94
Birmingham-Southern College, Birmingham, AL, B.S. Mathematics / Biology, 9/86 - 6/90

HONORS:
7/2002 - 6/2005, Pfizer Scholars Grant for Faculty Development in Clinical Epidemiology
2003-2011, 2013-2014 UAB Department of Medicine's Top Ten Teacher Award for Excellence in Teaching
2004-2006, 2008-2014, UAB Department of Medicine's C. Glenn Cobbs, MD-Edwin A. Rutsky, MD Award for Clinical Excellence
2005-2006, Consumers' Research Council of America's "America's Top Physicians"
5/2007, UAB Argus Award for Excellence in Teaching, University of Alabama School of Medicine Class of 2008
2007-2014, Best Doctors in America
4/2008, UAB Argus Award for Best Lecturer in Urinary/Renal Correlative Pathology for Class of 2009
3/2009, UAB Argus Award for Best Lecturer in Urinary/Renal Correlative Pathology for Class of 2010
3/2009, UAB Argus Award for Best Lecturer for the Renal Module for the Class of 2011
2009, NxStage: Taking CRRT to the Next Stage 2009 Grant: A Pilot and Feasibility Study of Antimicrobial Dosing in CRRT
2010-2012, UAB Department of Medicine Education Excellence Award
2011, UAB Argus Award for Best Lecturer for the Renal Module for Class of 2013
2012, UAB Outstanding Teacher in Nephrology
2012, Argus Award for Best Lecturer for the UAB Renal Module for Class of 2015
2013, Argus Award for Best Lecturer for the UAB Renal Module for Class of 2017
2013, National Academy of Inventors Award

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology     
International Society for Peritoneal Dialysis     
International Society of Nephrology     
National Kidney Foundation     
Southern Society of Clinical Investigation     

Selected Publications 
Publication PUBMEDID
Tolwani AJ. A Patient with AKI after Cardiac Surgery. Clin J Am Soc Nephrol. 2014 Mar 20. PMID: 24651071   
Bagshaw SM, Uchino S, Kellum JA, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van Straaten HM, Ronco C, Bellomo R; Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigators. Association between renal replacement therapy in critically ill patients with severe acute kidney disease and mortality. J Crit Care. 2013 Dec; 28(6):1011-8. doi: 10.1016/j.jcrc.2013.08.002. Epub 2013 Sep 24   
Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD.KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury. Am J Kidney Dis. 2013 Mar 14. doi:pii: S0272-6386(13)00471-X. 10.1053/j.ajkd.2013.02.349   
Tolwani A. Continuous renal-replacement therapy for acute kidney injury. N Engl J Med. 2012 Dec 27;367(26):2505-14. doi: 10.1056/NEJMct1206045   
Tolwani A, Wille KM. Advances in continuous renal replacement therapy: citrate anticoagulation update. Blood Purification. 2012;34(2):88-93.doi: 10.1159/000342378. Epub 2012 Oct 24   
Tumlin JA, Chawla L, Tolwani AJ, Mehta R, Dillon J, Finkel KW, Dasilva JR, Astor BC, Yevzlin AS, Humes HD. The Effect of the Selective Cytopheretic Device on Acute Kidney Injury Outcomes in the Intensive Care Unit: A Multicenter Pilot Study. Semin Dial. 2012 Oct 29. doi: 10.1111/sdi.12032   
Nadim MK, Kellum JA, Davenport A, Wong, F, Davis, C, Pannu N, Tolwani A, Bellomo R, Genyk Y. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) group. Critical Care 2012, Feb 9;16(1):R23. doi: 10.1186/cc11188    
Bauer SR, Salem C, Connor MJ Jr, Groszek J, Taylor ME, Wei P, Tolwani AJ, Fissell WH. Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT. Clin J Am Soc Nephrol. 2012 Jan 26. [Epub ahead of print]   
Lyndon WD, Wille K, Tolwani AJ. Solute clearance in CRRT: prescribed dose versus actual delivered dose Nephrol. Dial. Transplant. (2011) first published online September 5, 2011 doi:10.1093/ndt/gfr480    
Cerdá J, Tolwani AJ, Warnock DG. Critical care nephrology: management of acid-base disorders with CRRT. Kidney Int. 2011 Aug 3. doi: 10.1038/ki.2011.243.   
Kang SW, Shih PA, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, Oconnor DT. Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16;12(1):27   
Cerdá J, Tolwani A, Gibney N, Tiranathanagul K. Renal replacement therapy in special settings: extracorporeal support devices in liver failure. Semin Dial. 2011 Mar;24(2):197-202. doi: 10.1111/j.1525-139X.2011.00827.x   
Shingarev R, Wille K, Tolwani A. Management of complications in renal replacement therapy. Semin Dial. 2011 Mar;24(2):197-202. doi: 10.1111/j.1525-139X.2011.00827.x.   
Humes, H.D., Sobota, J.T., Ding, F. & Song, J.H. RAD Investigator Group. A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure. Blood Purif 29, 183-190 (2010).   
Rosner, M.H., Berns, J. S., Parker, M., Tolwani, A., Bailey, J., DiGiovanni, S., Lederer, E., Norby, S., Plumb, T. J., Qian, Q., Yeun, J., Hawley, J. L., Owens, S. Development, implementation, and results of the ASN in-training examination for fellows. Clin J Am Soc Nephrol 5, 328-334 (2010   
Bagshaw, S.M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A. Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care 24, 129-140 (2009).   
Hayes, L.W., Oster, R.A., Tofil, N.M. & Tolwani, A.J. Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care 24, 394-400 (2009).   
Bagshaw, S.M., Uchino, S., Cruz, D., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A.. A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury. Nephrol Dial Transplant 24, 2739-2744 (2009   
Davenport A, Tolwani A. Citrate anticoagulation for continuous renal replacement therapy (CRRT) in patients with acute kidney injury admitted to the intensive care unit. NDT Plus (2009) 2: 439–447   
Tolwani, A.J. & Palevsky, P.M. Introduction. The clinical application of CRRT--current status. Semin Dial 22, 107 (2009).   
Tolwani, A.J. & Wille, K.M. Anticoagulation for continuous renal replacement therapy. Semin Dial 22, 141-145 (2009).   
Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Straaten, H. O., Ronco, C., Kellum, J. A.. Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med 37, 2576-2582 (2009   
Davenport, A., Bouman, C., Kirpalani, A., Skippen, P., Tolwani, A., Mehta, R. L., Palevsky, P. M.. Delivery of renal replacement therapy in acute kidney injury: what are the key issues? Clin J Am Soc Nephrol 3, 869-875 (2008).   
Tumlin, J., Wali, R., Williams, W., Murray, P., Tolwani, A. J., Vinnikova, A. K., Szerlip, H. M., Ye, J., Paganini, E. P., Dworkin, L., Finkel, K. W., Kraus, M. A., Humes, H. D.. Efficacy and safety of renal tubule cell therapy for acute renal failure. J Am Soc Nephrol 19, 1034-1040 (2008).   
Tolwani, A., Paganini E, Joannidis M, Zamperetti N, Verbine A, Vidyasagar V, Clark W, Ronco C. Treatment of patients with cardiac surgery associated-acute kidney injury. Int J Artif Organs 31, 190-196 (2008).   
Tolwani, A.J., Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM. Standard versus high-dose CVVHDF for ICU-related acute renal failure. J Am Soc Nephrol 19, 1233-1238 (2008).   
Pisoni, R., Wille, K.M. & Tolwani, A.J. The epidemiology of severe acute kidney injury: from BEST to PICARD, in acute kidney injury: new concepts. Nephron Clin Pract 109, c188-191 (2008).   
Tolwani, A.J., Wheeler, T.S. & Wille, K.M. Sustained low-efficiency dialysis. Contrib Nephrol 156, 320-324 (2007).   
Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H., Ronco, C., Kellum, J. A.. Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med 33, 1563-1570 (2007).   
Bagshaw, S.M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A.. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol 2, 431-439 (2007).   
Tolwani, A. & Wille, K.M. Citrate-based replacement solutions with continuous venovenous hemofiltration: not as simple as it sounds. Am J Kidney Dis 47, 1086; author reply 1086-1087 (2006).   
Tolwani, A.J., Prendergast, M.B., Speer, R.R., Stofan, B.S. & Wille, K.M. A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance. Clin J Am Soc Nephrol 1, 79-87 (2006   
O'Reilly, P. & Tolwani, A. Renal replacement therapy III: IHD, CRRT, SLED. Crit Care Clin 21, 367-378 (2005).   
Tolwani, A. Renal replacement therapies for acute renal failure: does dose matter? Am J Kidney Dis 45, 1139-1143 (2005).   
Uchino, S., Kellum, J. A., Bellomo, R., Doig, G. S., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Ronco, C.. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294, 813-818 (2005).   
Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Doig, G. S., Oudemans van Straaten, H., Ronco, C., Kellum, J. A. External validation of severity scoring systems for acute renal failure using a multinational database. Crit Care Med 33, 1961-1967 (2005).   
Warnock DG, Tolwani AJ, Gallichio M, Allon M. Vascular grafts for hemodialysis: types, sites and techniques, Contrib Nephrol. 2004; 142:73-93.   
Uchino S, Doig GS, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Nacedo E, Gibney N, Tolwani A, Ronco C, Kellum JA; Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigators, Diuretics and mortality in acute renal failure, Crit Care Med. 2004 Aug;32(8):1669-77   
Tolwani A, Campbell RC, Schenk MB, Allon M, Warnock DG. Simplified Citrate Anticoagulation for Continuous Renal Replacement Therapy, Kidney International 2001:60:370-374   
Miller PE, Tolwani A, Luscy CP, Deierhoi MH, Bailey R, Redden DT, Allon M. Predictors of adequacy of arteriovenous fistulas in hemodialysis patients. Kidney International. 56 (1): 275-80, 1999 Jul.   

Keywords
Acute Renal Failure, Acute Kidney Injury, Continuous Renal Replacement Therapy, Critical Care Medicine