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Faculty Detail    
Name MICHAL MRUG
 
Campus Address THT 611J Zip 0007
Phone 205-934-9509
E-mail mmrug@uab.edu
Other websites
      ICM Preceptor


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Associate Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor
Center  Heflin Genetics Center  Heflin Genetics Center Associate Professor
Center  Medicine  Nephrology Res & Trng Ctr Associate Professor

Biographical Sketch 
Dr. Mrug received his M.D. at the Charles University in Prague, Czech Republic. He completed his internship and residency in Internal Medicine at the University of South Alabama in Mobile and fellowship in Nephrology at the University of Alabama at Birmingham (UAB). In 2004, he joined the UAB Division of Genetic and Translational Medicine as Instructor of Medicine and in 2005 was promoted to Assistant Professor. In 2008, he joined the UAB Division of Nephrology. Dr. Mrug is certified by the American Board of Internal Medicine and by the Subspecialty Board on Nephrology. His clinical interests center on evaluation and management of adult patients with polycystic kidney disease (PKD). His current research focuses on the identification of specific genes and molecular pathway that modulate the severity of PKD and its progression.

Society Memberships
Organization Name Position Held Org Link
American Society of Nephrology  member  http://www.asn-online.org 

Research/Clinical Interest
Title
Pathogenesis of polycystic kidney disease progression
Description
Polycystic kidney disease (PKD) progression in both people and mouse models is highly variable. Specific biological processes that contribute to this variability remain largely unknown. Dr. Mrug’s current research focus is on the identification of biological processes and molecular pathways that modulate PKD progression. He also continues his collaboration with Dr. Guay-Woodford aimed at the identification of non-PKD genes that contribute to phenotypic variability in PKD. Both the identification of PKD modifier genes and molecular pathways associated with rapid PKD progression are critical steps for the discovery of new markers that would predict PKD course and for the development of novel therapies to cure PKD.

Selected Publications 
Publication PUBMEDID
Zhou J, Ouyang X, Schoeb TR, Bolisetty S, Cui X, Mrug S, Yoder BK, Johnson MR, Szalai AJ, Mrug M. Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement. J Am Soc Nephrol. 2012;23(7):1161-71  22518005 
Krejčí E, Pesevski Z, DeAlmeida AC, Mrug M, Fresco VM, Argraves WS, Barth JL, Cui X, Sedmera D. Microarray analysis of normal and abnormal chick ventricular myocardial development. Physiol Res. 2012;61 Suppl 1:S137-44  22827870 
Dawoud D, Lyndon W, Mrug S, Bissler JJ, Mrug M. Impact of ultrasound-guided kidney biopsy simulation on trainee confidence and biopsy outcomes.
Am J Nephrol. 2012;36(6):570-4. 
23221146 
Kistler AD, Serra AL, Siwy J, Poster D, Krauer F, Torres VE, Mrug M, Grantham JJ, Bae KT, Bost JE, Mullen W, Wüthrich RP, Mischak H, Chapman AB. Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS One. 2013;8(1):e53016  23326375 
Sharma N, Malarkey EB, Berbari NF, O'Connor AK, Vanden Heuvel GB, Mrug M, Yoder BK. Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J Am Soc Nephrol. 2013 Feb;24(3):456-64  23411784 
Bae K, Park B, Sun H, Wang J, Tao C, Chapman AB, Torres VE, Grantham JJ, Mrug M, Bennett WM, Flessner MF, Landsittel DP, Bae KT; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Segmentation of individual renal cysts from MR images in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2013 Jul;8(7):1089-97  23520042 
Mrug M, Sanders PW. Beware the low HDAC11: males at risk for ischemic kidney injury. Am J Physiol Renal Physiol. 2013 Oct;305(7):F973-4  23884138 
Langenkamp E, Kamps JA, Mrug M, Verpoorte E, Niyaz Y, Horvatovich P, Bischoff R, Struijker-Boudier H, Molema G. nnovations in studying in vivo cell behavior and pharmacology in complex tissues - microvascular endothelial cells in the spotlight. Cell Tissue Res. 2013  24072341 
Bae KT, Tao C, Wang J, Kaya D, Wu Z, Bae JT, Chapman AB, Torres VE, Grantham JJ, Mrug M, Bennett WM, Flessner MF, Landsittel DP. Novel Approach to Estimate Kidney and Cyst Volumes Using Mid-Slice Magnetic Resonance Images in Polycystic Kidney Disease. Am J Nephrol. 2013 Oct 5;38(4):333-341  24107679 

Keywords
polycystic kidney disease, innate immunity, mouse models, genome-wide expression profiling