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|
Appointment Type |
Department |
Division |
Rank |
| Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Assistant Professor |
| Primary |
Medicine |
Med - Cardiovascular Disease |
Assistant Professor |
|
|
Date Posted |
Position Title |
| 10/01/2012 |
Cardiovascular Disease |
A postdoctoral position is available immediately for a self-motivated individual to work on an NIH funded project focusing on cardiovascular disease. The successful candidate will employ in vitro and/or in vivo models to examine the roles of oxidative damage and mitochondrial dysfunction on cellular electrophysiology and cardiac function.
The applicants must have a Ph.D. or MD/PhD in biomedical science or other related disciplines, with strong background/expertise in one or more of the following areas: molecular cardiology, mitochondrial biology, and cardiac electrophysiology. Expertise in cardiomyocytes isolation, cell culture, DNA recombination, adenoviral/lentiviral vector production, and cell transduction are required. Previous experiences in patch clamp, live cell imaging, or small animal surgery are highly desirable. Responsibilities will include design and execution of experimental procedures, the maintenance of complete laboratory records of experiments, the preparation of manuscripts suitable for publication and presentations at internal and external venues as required. |
|
| Publication |
PUBMEDID |
Zhou L and O’Rourke B. "Cardiac mitochondrial network excitability: insights from computational
analysis". Am J Physiol Heart Circ Physiol 302: H2178-89, 2012. |
22427517 |
| Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, and Yu X. “Analysis and prediction of cardiac metabolism and transport: role of malate-aspartate shuttle.” J of Theor Bio, 254(2):466-75, 2008. |
18603266 |
| Plank G, Zhou L, Greenstein J, Cortassa S, Winslow R, O’Rourke B and Trayanova N. “From mitochondrial ionic channels to arrhythmias in the heart.” Philos Transact A Math Phys Eng Sci, 366(1879):3381-409, 2008. |
18603526 |
| Zhou L, Salem JE, Saidel GM, Stanley WC, and Cabrera ME. “Mechanistic model of cardiac energy metabolism predicts localization of glycosis to cytosolic sub-domain during ischemia.” Am J Physiol Heart Circ Physiol, 288: H2400-H2411, 2005. |
15681693 |
| Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. “Lactate production at the onset of ischemia is regulated by glycolysis and the transfer of NADH into mitochondria independent of mitochondrial NADH/NAD+: insights from in silico studies.” J Physiol (Lond), 569: 925-937, 2005. |
16223766 |
| Zhou L, Cabrera ME, Okere IC, Sharma N, and Stanley WC. “Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.” Am J Physiol Heart Circ Physiol, 291: H1036-H1046, 2006. |
16603683 |
| Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, and Stanley WC. “Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation.” J Physiol (Lond), 579, 811-21, 2007 |
17185335 |
| Zhou L, Huang H, McElfresh TA, Prosdocimo T, and Stanley WC. “Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.” Am J Physiol Heart Circ Physiol, 295(3):H939-45, 2008 |
18660443 |
| Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, and Stanley WC. “Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.” Am J Physiol Heart Circ Physiol, 294(2): H954-60, 2008. |
18083904 |
| Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L and O’Rourke B. “From mitochondrial dynamics to arrhythmias.” Int J Biochem Cell Biol. 41(10): 1940-1948, 2009. |
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