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Faculty Detail Faculty Entry   
Name JIANHUA ZHANG  
Campus Address BMR2 534 Zip 2180
Phone 205-996-5153
E-mail zhanja@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:zhanja@uab.edu">zhanja@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Center for Aging  Center for Aging Associate Professor
Center  Civitan International Research Center  Civitan International Research Center Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor
Center  Neurology   Neuro-Oncology Center Associate Professor
Primary  Pathology   Joint Pathology Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Neurobiology  Neurobiology Assistant Professor

Biographical Sketch 
Dr. Zhang graduated from University of Science and Technology of China. She received her PhD from University of Texas Southwestern Medical Center at Dallas. She then worked as a postdoctoral associate in the Whitehead Institute for Biomedical Research, and as a Research Assistant Professor in University of Cincinnati College of Medicine. She joined UAB in 2005.

Society Memberships
Organization Name Position Held Org Link
American Physiology Society  member   
Association for Neuron and Disease (AND)  member   
Birmingham Chinese Professor Association (BCPA)  president   
Chinese Biologic Investigator Society (Ray Wu society)  member   
Society for Free Radical Biology and Medicine (SFRBM)  council member   
Society for Neuroscience (SFN)  member   
Society of Chinese Bioscientists in America (SCBA)  member   
 

Research/Clinical Interest
Title
Mechanisms and regulation of autophagy-lysosomal pathway in health and diseases
Description
Our long-term research interests are to understand the cellular and molecular mechanisms responsible for autophagy, cellular bioenergetics, oxidative stress and cell death, in the context of human diseases. We use transgenic and conditional knockout mouse models, cell differentiation models to dissect mechanisms and pathways. Autophagy regulation is important for healthy aging, combating neurodegenerative, cardiovascular, liver and metabolic diseases. My laboratory currently constitutes 2 PhD earning graduate students, and 2 research associates. We are currently funded by VA and NINDS.

Postdoc Positions Available
Date Posted Position Title
03/29/2013  MSTP and PhD graduate students 
1 highly motivated, hardworking and talented graduate students who are interested in molecular cellular mechanisms of autophagy/mitophagy using mouse models, primary and differentiated cell models to study how autophagy is regulated by mitochondrial dysfunction, glucose metabolism, oxidative stress and protein aggregation, and how autophagic activities play a role in response to these cellular stress.   
 

Selected Publications 
Publication PUBMEDID
13. Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J (2013) Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neuroscience Letters in press
 		  
16. Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2012) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne In press
 		  
15. Parekh VV, Wu L, Boyd KL, Williams, JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WZ, Zhang J, Van Kaer L (2013) Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of Immunity In press
 		  
14. Errami Y, Brim H Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares HA (2013) ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability". PlosOne in press
 		  
11. Zhang J (2013) Autophagy and mitophagy in cellular damage control. Redox Biology. 1:19-23
 		  
7. Crabtree D, Zhang J (2012) Genetically engineered mouse models for Parkinson’s diseases. Brain Research Bulletin 88:13-32. NIHMS 316302
 		  
55. Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy, AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Boulares AH (2013) Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNase and the PARP-regulated DNas1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. in press   
10. Mitchell T, Bailey SM, Ballinger SW, Zhang J, Darley-Usmar VM (2013) Convergent mechanisms for mitochondrial dysfunction in metabolic disease; insights from mitochondrial therapeutics. Biochemical Society Transactions 41:127-133   
9. Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry 393:1485-1512   
5. Giordano S, Jisun Lee, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PlosOne 7(9):e44610. PMCID:PMC3435291  3435291 
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Keywords
Autophagy, Parkinson's Disease, Huntington's disease, signal transduction, mouse genetic engineering, cell and molecular biology, lysosomes, mitochondria, oxidative stress

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