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Faculty Detail Faculty Entry   
Name JACQUES I. WADICHE  
Campus Address SHEL 1005 Zip 2182
Phone 205-996-6413
E-mail jwadiche@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:jwadiche@uab.edu">jwadiche@uab.edu</a>
URL http://www.wadichelabs.com
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Civitan International Research Center  Civitan International Research Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor
Primary  Neurobiology  Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor

Biographical Sketch 
Jacques Wadiche graduated with a B.A. in Neurobiology and Physiology from Northwestern University where he gained an appreciation for basic science research. From there he worked on nicotinic acetylcholine receptors at Baylor College of Medicine before enrolling in graduate school at the Vollum Institute at Oregon Health Sciences University in Portland, Oregon. His thesis work revealed how glutamate transporters can function as both carriers and ligand-gated ion channels. During his postdoctoral fellowship in Craig Jahr’s laboratory at the Vollum Institute, he studied a phenomenon where the release of several vesicles occur with each action potential at individual synapses. This results in a very high glutamate concentration in the synapse that can saturate postsynaptic receptors and ensure excitation of the postsynaptic neuron. His postdoctoral work also demonstrated how altering the strength of neuronal uptake can determine the extent of extrasynaptic receptor activation. He joined the faculty at UAB as an Assistant Professor in 2006. His laboratory continues to study mechanisms that regulate vesicular release and neuro-glial signaling.

Society Memberships
Organization Name Position Held Org Link
No records
 

Research/Clinical Interest
Title
Synaptic transmission and glutamate transporters
Description
Our research focuses on the details of fast synaptic transmission. Experiments in the lab incorporate a multidisciplinary approach of electrophysiological, imaging methods, and molecular biological approaches to study the activity of synapses and glutamate transporters. One model system that we use to study synaptic transmission and glutamate uptake are slices from cerebellum.

Postdoc Positions Available
Date Posted Position Title
09/07/2010  Postdoctoral Fellow 
The postdoctoral position is available to study the mechanisms of excitatory synaptic transmission and synaptic plasticity. The candidate for this position should have experience in brain slice electrophysiology and an interest in imaging methods to studying the properties of individual neurons or glia. The candidate must have a doctoral degree in a relevant field and less than 5 years of postdoctoral experience. Candidates with a strong work ethic and excellent written and oral presentation skills are encouraged to apply. Salary is commensurate with experience and accomplishments.   
 

Selected Publications 
Publication PUBMEDID
Rudolph S., Overstreet-Wadiche L., Wadiche J.I. (2011) Desynchronization of multivesicular release enhances Purkinje cell output. Neuron, 70, 991-1004.  21658590 
Markwardt S.J., Wadiche J.I., and Overstreet-Wadiche L.S. (2009) Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus. J Neurosci., 29:15063-72.  19955357 
Tzingounis A.V. and Wadiche J.I. (2007) Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci., 8:935-47.  17987031 
Seguela, P., Wadiche, J., Dinelly-Miller, K., Dani, J., and Patrick, J. (1993). Molecular cloning, functional expression and distribution of a rat neuronal nicotinic channel highly permeant to calcium. J. Neurosci., 13, 596-604.  7678857 
Arriza, J.L., Fairman, W.P., Wadiche J.I., Murdoch, G.H., Kavanaugh, M.P., and Amara S.G. (1994). Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci., 14, 5559-5569.  7521911 
Wadiche, J.I., Arriza, J.L., Amara, S.G., and Kavanaugh, M.P. (1995). Kinetics of a human glutamate transporter. Neuron, 14, 1019-1027.  7748550 
Wadiche, J.I., Amara, S.G., and Kavanaugh, M.P. (1995). Ion fluxes associated with excitatory amino acid transport. Neuron, 15, 721-728.  7546750 
Wadiche, J.I. and Kavanaugh, M.P. (1998). Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J. Neurosci., 18, 7650-7661.  9742136 
Wadiche, J.I. and Jahr, C.E. (2001). Multivesicular release at climbing fiber-Purkinje cell synapses. Neuron, 32, 301-13.  11683999 
Kushmerick, C., Price, G., Tashenberger, H., Puente, N., Renden , R., Wadiche, J.I., Duvosin, R.M., Grandes, P., von Gersdorff, H. (2004). Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J. Neurosci., 24, 5955-65.  15229243 
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Keywords
glutamate transport, synaptic transmission, cerebellum

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