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Faculty Detail Faculty Entry   
Name GWENDALYN D KING  
Campus Address SHEL 913 Zip 2182
Phone 205-996-6247
E-mail gdking@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:gdking@uab.edu">gdking@uab.edu</a>
URL http://neurobiology-uab.infomedia.com/bios.asp?action=form&recordID=515139
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Center for Aging  Center for Aging Assistant Professor
Center  Civitan International Research Center  Civitan International Research Center Assistant Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor
Primary  Neurobiology  Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor

Biographical Sketch 
BS, Purdue University
MS, Ph.D. University of Michigan
Postdoctoral Fellow, Cedars-Sinai Medical Center/UCLA
Instructor, Boston University School of Medicine

Society Memberships
Organization Name Position Held Org Link
No records
 

Research/Clinical Interest
Title
Role of Klotho in aging and the brain
Description
We are interested in understanding the differences between normal and pathological brain aging. Present studies are focused on dissecting the role of Klotho in the brain and in the aging process. We are examining regulation of gene expression pre and post-transcriptional, protein distribution, localization and function in the brain, and Klotho's role in glioma.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
King GD, Huang MM, Schuman ER, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules to modulate transcription of Klotho. Under review   
King GD, Muhammad AKM, Laroque D, Liu C, Kroeger KM, Castro MG, Lowenstein PR. Flt3L and TK gene therapy induces immunological surveillance that mediates a specific immune response against a brain tumor neo-antigen. Molecular Therapy, 2011 In press.   
King GD, Rosene DL, Abraham CR. Promoter methylation and age-related downregulation of klotho in rhesus monkey. Under review   
King GD, Turner RS. Adaptor protein interactions: modulators of Amyloid Precursor Protein metabolism and Alzheimer’s disease risk? Experimental Neurology. (2004)185: 208-19.   14736502 
Curtin JF*, King GD*, Candolfi M, Greeno RB, Kroeger KM, Lowenstein PR, Castro MG. Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current Topics in Medicinal Chemistry (2005) 5(12):1151-70.   16248789 
King GD*, Curtin JF*, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. Gene Therapy and Targeted Toxins for Glioma. Current Gene Therapy (2005) 5:535-557. PMID:   16457645 
King GD, Cherian K, Turner RS. X11&#945; impairs &#947;- but not &#946;-secretase cleavage of Amyloid Precursor Protein. Journal of Neurochemistry, (2005) 88 (4):971-82.   14756819 
King GD, Perez RG, Steinhilb ML, Gaut JR, Turner RS. X11&#945; modulates secretory and endocytic metabolism of the Amyloid Precursor Protein. Neuroscience. (2003)120, 143-154. PMID:   12849748  
Ali S*, King GD*, Curtin JF, , Xiong W, Puntel M, Liu C, Cheng Q, Prieto J, Lassmann H, Lowenstein PR, Castro MG. Combined immune-stimulation and conditional cytotoxic gene therapy provide long-term survival in a macroscopic glioma model. Cancer Research, (2005) 65 (16) :7194-204.   16103070 
Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG. Flt3 ligand recruits plasmacytoid dendritic cells to the brain. Journal of Immunology (2006) 176: 3566 – 3577.   16517725 
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Keywords
age, brain, klotho, glioma, molecular biology

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