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Faculty Detail Faculty Entry   
Name KAI JIAO  
Campus Address KAUL 768 Zip 0024
Phone 205-996-4198
E-mail kjiao@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:kjiao@uab.edu">kjiao@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Pathology   Cell Adhesion & Matrix Research Center Associate Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor
Center  Heflin Genetics Center  Heflin Genetics Center Associate Professor
Center  Medicine  Med - Cardiovascular Disease Associate Professor
Primary  Genetics   Genetics Research Div Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Pathology   Pathology Chair Office Assistant Professor
Secondary  Pediatrics   Pediatrics Chair Office Assistant Professor

Biographical Sketch 
M.D., Beijing Medical University (1992)
Ph.D., University of Iowa (2000)
Postdoctoral Training, Vanderbilt University Medical Center (2005)

Society Memberships
Organization Name Position Held Org Link
American Heart Association     
 

Research/Clinical Interest
Title
TGF-beta/Bmp signaling during cardiogenesis
Description
Reveal the functions of Tgf-beta/Bmp signaling pathway during cardiogenesis using mice as the model system.

Congenital heart defects occur in as many as 1% of newborns, and are the leading cause of infant morbidity and mortality. The most common disorders are caused by malformations in septum formation and valvulogenesis (septal-valvulogenesis) during cardiogenesis. Tgf-beta/Bmp signaling pathways play critical roles during many biological processes including septal-valvulogenesis. Through tissue specific inactivation of genes encoding Bmp4 and the type II receptor of Tgf-beta, Dr. Jiao developed two unique mouse models mimicking two forms of human congenital heart disease during his postdoctoral training period. The current focus of the lab is to reveal the functions of Tgf-beta/Bmp signaling during cardiogenesis utilizing the powerful tools of mouse molecular genetics complemented with cellular and biochemical approaches.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Debenedittis P, and Jiao K (2011) Alternative splicing of T-box transcription factor genes.
Biochem. Biophys. Res. Commun. 412:513-517 (Epub, Aug. 11th, 2011)
 		 21856288 
Espinoza-Lewis RA, Liu H, Sun C, Chen C, Jiao K, Chen YP (2011) Ectopic expression of
Nkx2.5 suppresses the formation of the sinoatrial node in mice. Dev. Biol. 356:359-69,
(Epub. May 26th, 2011)
 		 21640717 
Debenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K (2011) Characterization of the novel
interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem. Biophys. Res. Commun. 409:338-43 (Epub, May 8th, 2011)
 		 21586270 
Nie X, Wang Q and Jiao K (2011) Dicer activity in neural crest cells is essential for
craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mechanisms of
Development 128:200-7 (Epub, Jan. 21st, 2011)
 		 21256960 
Nie X, Brown C, Wang Q and Jiao K (2011) Inactivation of Bmp4 from the Tbx1 expression
domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs 193:393-403 ( Epub, Dec. 1st, 2010)
 		 21123999 
Song L., Zhao M, Wang Q and Jiao K (2011) Cell autonomous requirement of endocardial
Smad4 during atrioventricular cushion development in mouse embryos. Dev. Dyn. 240: 211-220 (Epub, Nov. 18th, 2010)
 		 21089072 
Wang B, Sinha T, Jiao K, Serra R, and Wang J (2011) Disruption of PCP signaling causes
limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum. Mol. Genet. 20:271-285 (Epub, Nov. 8th, 2010)
 		 20962035 
Lu R, Chen Y, Peng N, Jiao K, Limbird LE, Wyss JM and Wang Q (2009) Enhanced
hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Mol. Pharm. 78:279-86
 		 20430865 
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE,
Zhou Y, Wang Q. (2009) Epitope-tagged receptor knock-in mice reveal that differential
desensitization of {alpha}2-Adrenergic responses Is because of ligand-selective
Internalization. J Biol Chem. 284:13233-43
 		 19276088 
Xu J, Chen Y, Lu R, Cottingham C, Jiao K and Wang Q (2008) Protein Kinase A Phosphorylation of Spinophilin Modulates Its Interaction with the {alpha}2A-Adrenergic Receptor (AR) and Alters Temporal Properties of {alpha}2AAR Internalization. J Biol Chem. 283:14516-23  18367453 
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Keywords
Tgfbeta, BMP, heart development, mouse genetics, development

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