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Faculty Detail Faculty Entry   
Name W TIMOTHY GARVEY  
Campus Address WEBB 230 Zip 3360
Phone 205-934-6103
E-mail garveyt@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:garveyt@uab.edu">garveyt@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center
Center  Center for Aging  Center for Aging
Center  Medicine  Comprehensive Diabetes Ctr
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine
Center  Medicine  Med - Cardiovascular Disease
Center  Medicine  Med - Nephrology
Center  General Clinical Research Center  Minority Health & Research Center
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Medicine  Med - Endocrinology, Diabetes & Metabolism Professor

Biographical Sketch 
After his undergraduate studies at Washington University, Dr. Garvey proceeded to earn his MD from St. Louis University’s School of Medicine in 1978. He then completed his internship (1978-1979) and residency (1979-1980) on the staff of Barnes Hospital, Washington University. Dr. Garvey went on to complete a fellowship in Endocrinology and Metabolism at the University of California at San Diego Medical Center (1983-1984) and University of Colorado Health Science Center (1982-1983). After faculty positons at UCSD, Indiana University, and the Medical University of South Carolina, he came to the University of Alabama at Birmingham where he is currently Professor and Chairman of the Department of Nutrition Sciences.

Society Memberships
Organization Name Position Held Org Link
No records
 

Research/Clinical Interest
Title
Molecular and physiological pathogenesis of human insulin resistance
Description
Dr. Garvey has achieved international recognition for his research in the metabolic, molecular, and genetic pathogenesis of insulin resistance, Type 2 Diabetes, and obesity. His studies have involved the cellular and molecular biology of cell and animal models, metabolic investigations of human subjects on metabolic research wards, and the genetic basis of diseases in Gullah-speaking African Americans, Pima Indians, and national cohorts of diabetes patients. He has brought basic technology directly to the study of human patients, and the combined approach of human physiology, genetics, and basic cell and molecular biology has provided the laboratory with a flexible capability for hypothesis testing relevant to human disease. By studying molecular parameters and differential gene expression in muscle and fat tissue from metabolically characterized individuals, the Garvey laboratory has made important observations regarding the pathogenesis of human insulin resistance. He has been a principle contributor to our understanding of the role of the glucose transport system and glucose transporter proteins in human insulin resistance. He is using cDNA microarray and mitochondrial proteomics to better define mitochondrial defects that impair substrate oxidation in human muscle from insulin resistant subjects. The laboratory has also identified a polymorphism in the uncoupling protein 3 gene as a ‘thrifty gene’ and susceptibility gene for severe obesity in African Americans. The laboratory is actively studying mechanisms of mitochondrial dysfunction contributing to muscle insulin resistance, and the role of secreted adipocyte factors in the pathogenesis of the Metabolic Syndrome. He also served as the PI of an NIH-funded Program Project to study markers and mechanisms of diabetes vascular complications in collaboration with two national trial cohorts. Dr. Garvey has directed an independent laboratory since 1987 supported by the National Institutes of Health (NIDDK, NHLBI), the Department of Veterans Affairs, the AHA, JDFI, the ADA, and other agencies. He is also the Director of the NIH P60 Diabetes Research and Training Center at UAB.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
No records
 

Keywords
Insulin resistance, obesity, Metabolic Syndrome, Type 2 Diabetes

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