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Faculty Detail Faculty Entry   
Name CATHERINE M FULLER  
Campus Address MCLM 830 Zip 0005
Phone 205-934-6227
E-mail cfuller@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:cfuller@uab.edu">cfuller@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor
Center  Medicine  Med - Nephrology Associate Professor
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Cell Biology   Cell Biology Associate Professor

Biographical Sketch 
Cathy Fuller, Ph.D. (Associate Professor), received her B.Sc. (Hons.) degree from the University of London (1982), and her Ph.D. from the University of Liverpool (1985), in the laboratory of Prof. O.H. Petersen. She was a post-doctoral fellow in the laboratory of Dr. I. Schulz at the Max Planck Institut fur Biophysik (Frankfurt, Germany), from 1985-1988. She joined the Dept. of Physiology and Biophysics as a post-doctoral fellow in the laboratory of Dr. Dale J. Benos in 1988. She joined the faculty of the department in 1995.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society  Steering Committee, Cell and Molecular Physiology Section  www.the-aps/org 
 

Research/Clinical Interest
Title
ENaC/ASIC Ion Channels;
Description
My lab is interested in the molecular mechanisms underlying the function of epithelial and astrocyte Na+ channels. These cell membrane proteins have important roles to play in the regulation of whole-body salt and water homeostasis, as well as in cell migration and proliferation in disease states such as cancer and renal disease. Current projects in the lab include analysis of ASIC/ENaC family members and their interaction with MAPK/ERK signaling pathways with relevance to migration and proliferation in gliomas, trafficking of these channel subunits in gliomas and their role in lipid rafts, and the role of a novel ENaC/ASIC chnnel in polycystic kidney disease. We use techniques such as fluorescence imaging, RT-PCR, site-directed mutagenesis and electrophysiology.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Kapoor, N., Lee, W., Clark, E, Bartoszewski, R., McNicholas, C.M., Latham, C., Bebok, Z., Parpura, V., Fuller, C.M., Palmer, C., Benos, D.J. Acidosis increases ASIC1 plasma membrane expression in glioblastoma multiforme. Am. J. Physiol. Cell Physiol. 300: C1246-C1259, 2011. Selected for “Highlights from the Literature” Editorial Section in Physiology
 		 21346156 
Clark, E.B., Jovov, B., Rooj, A.K., Fuller, C.M., and Benos, D.J. Proteolytic cleavage of the human acid-sensing ion channel 1 by the serine protease matriptase. J. Biol. Chem. 285:27130-27143, 2010.  20601429 
Qadri, Y.J., Y. Song, C.M. Fuller, and D.J. Benos. Amiloride docking to acid-sensing ion channel 1. J. Biol. Chem. 285:9627-9635, 2010.  20048170 
Kapoor, N., R. Bartoszewski, Y.J. Qadri, Z. Bebok, J.K. Bubien, C.M. Fuller, and D.J. Benos. Knockdown of ASIC1 and ENaC subunits inhibits glioblastoma whole cell current and cell migration. J. Biol. Chem. 284:24526-24541, 2009.  19561078 
Qadri, Y.J., B.K. Berdiev, Y. Song, H.L. Lippton, C.M. Fuller, and D.J. Benos. Psalmotoxin-1 docking to human acid-sensing ion channel 1. J. Biol. Chem. 284: 17625-17633, 2009.  19395383 
Bashari, E., Y.J. Qadri, Z.H. Zhou, N. Kapoor, S.J. Anderson, R.H. Meltzer, C.M. Fuller and D.J. Benos. Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function. Am. J. Physiol. 296: C372-C384, 2008.  19091960 
Ross, S.B. C.M. Fuller, J.K. Bubien, and D.J. Benos. Amiloride and psalmotoxin-sensitive Na+ channels contribute to regulatory volume increases in high grade glioma cells. Am. J. Physiol. Cell Physiol. (2007) 293:C1181-C1185.   17615161  
Meltzer, R.H., N. Kapoor, Y.J. Qadri, S.J. Anderson, C.M. Fuller and D.J. Benos. Heteromeric assembly of ASIC and ENaC subunits in glioma. (2007) J. Biol. Chem. 282:25548-25559.  17613525 
Vila-Carriles, W., Z.-H. Zhou, C.M. Fuller, and D.J. Benos. Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells. J. Biol. Chem (2007) 282:34381-34391  17878160 
Vila-Carriles, W., G. Gy. Kovacs. Y. Qadri, B. Jovov, Z.-H. Zhou, A.K. Pahwa, G. Colby, O. Esimai, G.Y. Gillespie, T.B. Mapstone, J.M. Markert, C.M. Fuller, J.K. Bubien, and D.J. Benos, Surface expression of ASIC2 inhibits the amiloride sensitive current and migration of glioma cells (2006) J. Biol. Chem. 281, 19220-32  16704974  
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Keywords
Sodium channels, glioma, migration, proliferation, cancer, signaling, polycystic kidney disease

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