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Faculty Detail Faculty Entry   
Name STEVEN L CARROLL  
Campus Address SC 930G Zip 0017
Phone 205-934-9828
E-mail scarroll@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:scarroll@uab.edu">scarroll@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Neurology   Alzheimer's Disease Center Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor
Center  Neurology   Neuro-Oncology Center Professor
Primary  Pathology   Clinical Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Neurobiology  Neurobiology Professor

Biographical Sketch 
Dr. Carroll received his B.S. degree from the University of Memphis. He then attended Baylor College of Medicine, receiving his Ph.D. in Cell Biology in 1986 and his M.D. in 1988. Dr. Carroll’s postdoctoral research fellowship, Anatomic Pathology Residency and Neuropathology Fellowship were performed at the Washington University School of Medicine (1988-1994). At the completion of this training, Dr. Carroll was appointed as an Assistant Professor in the Department of Pathology at Washington University School of Medicine. In 1997, Dr. Carroll moved to UAB, where he joined the Department of Pathology as an Assistant Professor. In 2001, he was promoted to the rank of Associate Professor and in 2008 was promoted to the rank of Professor and appointed as Director of the Division of Neuropathology. Dr. Carroll holds joint appointments in the Departments of Neurobiology and Cell Biology. He also serves as a Scientist in the Center for Aging, the Alzheimer’s Disease Research Center, the Intellectual and Developmental Disabilities Research Center, the Civitan International Research Center, the Comprehensive Neuroscience Center, the Center for Glial Biology in Medicine, the Center for Neurodegeneration and Experimental Therapeutics and the Center for Clinical and Translational Science and as an Senior Scientist in the Comprehensive Cancer Center.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     
American Association of Neuropathologists     
American Society for Investigative Pathology     
American Society for Neurochemistry     
Birmingham Chapter, Society for Neuroscience     
Jefferson County Medical Society     
Medical Association of the State of Alabama     
Society for Neuro-Oncology     
Society for Neuroscience     
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Research/Clinical Interest
Title
Genomic, Epigenetic and Signaling Abnormalities Driving the Pathogenesis of Neurofibromatosis Type 1 Associated Peripheral Nerve Sheath Tumors
Description
Research in my laboratory is focused on the mechanisms underlying the pathogenesis of peripheral nerve sheath tumors in neurofibromatosis type 1 (NF1) and the development of treatments for these neoplasms. Patients with NF1, the most common genetic disease affecting the human nervous system, develop benign neurofibromas that can progress and give rise to aggressive sarcomas known as malignant peripheral nerve sheath tumors (MPNSTs); at present, there is no effective way of treating MPNSTs and consequently these neoplasms are a major cause of mortality for NF1 patients. We have hypothesized that aberrant signaling by neuregulin-1 (NRG-1) growth factors promotes the pathogenesis of NF1-associated peripheral nerve sheath tumors and that inhibition of NRG-1 associated signaling cascades may be an effective means of treating MPNSTs. In support of this hypothesis, we have found that the proliferation and invasive behavior of neoplastic Schwann cells isolated from human neurofibromas and MPNSTs is dependent on NRG-1 signaling mediated by erbB membrane tyrosine kinases. We have also produced transgenic mice that express the NRG-1 isoform GGFbeta3 in Schwann cells (P0-GGFbeta3 mice) and have found that that these animals develop multiple neurofibromas, some of which subsequently give rise to MPNSTs. Ongoing studies in my laboratory suggest that NRG-1 overexpression in P0-GGFbeta3 mice is not sufficient for tumorigenesis and that mutations of tumor suppressor genes such as Nf1, p53, Rb and CDKN2A cooperate with NRG-1 signaling to promote the development of peripheral nerve sheath tumors; we are currently using mice with conditional knockouts of these genes to directly test this hypothesis. We have also developed mice with conditional null mutations of erbB receptors that are allowing us to establish the contribution specific erbB kinases make to tumorigenesis in P0-GGFbeta3 mice and in animals with null mutations of the Nf1 locus. Finally, we have an ongoing series of preclinical studies that are evaluating three novel classes of compounds to determine whether these compounds effectively inhibit the growth of MPNSTs in our transgenic and knockout mouse models and in a model in which human MPNST cells are orthotopically grafted into mice. These studies will yield significant new data on the pathogenesis of NF1-associated peripheral nerve sheath tumors and hopefully will lead to the development of effective new treatments for these neoplasms.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Bjornsti MA, Carroll SL and Roth KA. 4-hydroxy-tamoxifen induces autophagic death through K-Ras degradation. Cancer Research 2013 (In press).   23722551 
Reitz C, Jun G, Naj AC, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Beach TG, Beecham GW, Beekly D, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, Cruchaga C, DeCarli C, DeKosky ST, Demirci FY, Dick M, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Growdon JH, Hakonarson H, Hamilton RL, Hamilton-Nelson K, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Karlawish J, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, LaFerla FM, Lah JJ, Lang-Walker R, Leverenz JB, Levey AI, Li G, Lieberman AP, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Olichney JM, Parisi JE, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE and Yu L. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E &#949;4, and the risk of late-onset Alzheimer disease in African Americans. Journal of the American Medical Association 2013; 309(14): 1483-1492.  23571587 
Cruchaga C, Kauwe JSK, Harari O, Jin SC, Cai Y, Karch CM, Benitez B, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VMY, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, the GERAD Consortium, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Albert MS, Albin RL, Apostolova LG, Baldwin CT, Barmada MM, Barnes LL, Beach TG, Beecham GW, Beekly D, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Crane PK, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hamilton-Nelson KL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Murrell JR, Myers AJ, Naj AC, Olichney JM, Pankratz VS, Parisi JE, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Troncoso JC, Tsuang DW, Valladares O, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L and Goate AM. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease. Neuron 2013; 78(2): 256-268.  23562540 
Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Wakutani Y, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Na DL, Ki CS, Seo SW, Mook-Jung I, Albert MS, Albin RL, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Barnes LL, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton-Nelson KL, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Kamboh MI, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lin CF, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Myers AJ, Naj AC, Olichney JM, Pankratz VS, Parisi JE, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA and Kuwano R. SORL1 is genetically associated with late-onset Alzheimer’s disease in Japanese, Koreans and Caucasians. PLoS One 2013; 8(4): e58618 doi:10.1371/journal.pone.0058618.   23565137 
Byer SJ, Brossier NM, Peavler LT, Eckert JM, Watkins S, Roth KA and Carroll SL. Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Journal of Neuropathology and Experimental Neurology 2013; 72(3): 219-233.  23399900 
Holton P, Ryten M, Nalls M, Trabzunin D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Cotman CW, Crane PK, Crocco EA, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dickson DW, Duara R, Ellis WG, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Naj AC, Nowotny P, Parisi JE, Peskind E, Petersen RC, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Shelanski ML, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Ramirez-Restrepo M, Engel A, Myers AJ, Corneveaux JJ, Huentelman MJ, Dillman A, Cookson MR, Reiman EM, Singleton A, Hardy J and Guerreiro R. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk loci. Annals of Human Genetics. 2013; 77(2): 85-105.  23360175 
Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RPH, Brossier NM, Grizzle WE, Mikhail FM, Roth KA and Carroll SL. Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis. The American Journal of Pathology 2013: 182(3): 646-677.  23321323 
Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, DeCarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JPG, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beecham GW, Beekly D, Bennett DAV, Blacker D, Bowen JD, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Clark DG, Corneveaux J, Cotman CW, Carne PK, Cruchaga C, Cummings JL, Jager De PL, DeCarli C, DeKosky ST, Demirci FY, Arrastia-Diaz R, Dick M, Duara R, Ellis WG, Taner-Ertekin NN, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Gallins PJ, Ganguli M, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head H, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Johnson N, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JSK, Kay JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller CA, Miller JW, Montine TH, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Hyslop-George St P, Stern RA, Tanzi RE, Tsuang DW, Vardarajan BN, Vinters HV, Wang LS, Weintraub S, Bohmer-Welsh KA, Williamson J, Woltjer RL, Younkin SG, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E and Geschwind DH. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer’s diseases. Human Molecular Genetics 2012; 21(15): 3500-3512.   22556362 
Whitcomb D, LaRusch J, Krasinskas AM, Klei L, Brand RE, Lerch MM, Tector M, Sandhu B, Guda NM, Alkaade S, Albert MS, Albin RL, Apostolova LG, Arnold SE, Baldwin CT, Barmada MM, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Blacker D, Boeve BF, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Cotman CW, Crocco EA, Cruchaga C, Cummings JL, DeCarli C, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Naj AC, Olichney JM, Parisi JE, Peskind E, Petersen RC, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Shelanski ML, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Woltjer RL, Wright CB, Younkin SG, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, Duerr R, Farrer LA, Forsmark C, Gardner TB, Gelrud A, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Singh V, Slivka A, Stolz D, Muniraj T, Weiss FU, Wilcox CM, Wisniewski S, O’Connell M, Roeder K, Barmada MM, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics 2012; 44(12): 1349-1354.   23143602 
Jun G, Vardarajan BN, Buros J, Yu CE, Hawk MV, Dombrowski BA, Crane PK, Larson EB, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dickson DW, Duara R, Ellis WG, Ertekin-Taner NN, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Johnson N, Kamboh MI, Karlawish J, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Younkin SG, Mayeux R, Haines JL, Lunetta KL, Pericak-Vance MA, Schellenberg GD and Farrer LA. Comprehensive search for Alzheimer Disease susceptibility loci in the APOE region. Archives of Neurology 2012; 69(10): 1270-1279.   22869155 
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Keywords
neurofibromatosis, Schwann cell, neuregulin, erbB

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