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Faculty Detail Faculty Entry   
Name SHANNON M BAILEY  
Campus Address VH G019 Zip 0019
Phone 205-934-7070
E-mail sbailey@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:sbailey@uab.edu">sbailey@uab.edu</a>
URL http://www.soph.uab.edu/default.aspx?id=646&action=detail&fsid=3236
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Medicine  Comprehensive Diabetes Ctr Associate Professor
Center  Medicine  Med - Cardiovascular Disease Associate Professor
Center  Medicine  Med - Nephrology Associate Professor
Primary  Pathology   Joint Pathology Associate Professor
Secondary  Pharmacology/Toxicology   Pharmacology/Toxicology Chair's Office Assistant Professor

Biographical Sketch 
Received Bachelor of Science in Zoology from the University of Oklahoma in 1989 Received PhD in Pharmacology from the University of Oklahoma Health Science Center, College of Medicine in 1996, Dissertation advisor: Lester A. Reinke, Dissertation title: Potential Mechanisms of Hepatic Ischemia-Reperfusion Injury. Postdoctoral Research Fellow, Department of Biochemistry, Wake Forest University School of Medicine from 3/96-2/99, Postdoctoral advisor: Carol C. Cunningham Instructor, Department of Biochemistry, Wake Forest University School of Medicine from 3/99-9/00 Assistant Professor, Department of Biochemistry, Wake Forest University School of Medicine from 10/00-8/01 Assistant Professor, Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham from 9/01-9/06 Associate Professor, Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham from 10/06 - 1/12; Associate Professor, Department of Pathology, Division of Molecular and Cellular Pathology, School of Medicine from 2/12 to present

Society Memberships
Organization Name Position Held Org Link
American Physiological Society  member  http://www.aps.org/ 
Biochemical Society  member  http://www.biochemistry.org/ 
Research Society on Alcoholism  member  http://www.rsoa.org/ 
Society for Free Radical Biology and Medicine  Editorial Board; member  http://www.sfrbm.org 
 

Research/Clinical Interest
Title
Molecular mechanisms of chronic alcohol and obesity induced fatty liver disease
Description
My research investigates how genetic, environmental, and life-style factors influence the initiation, progression, and severity of liver diseases and how these alterations impact risk for cardiovascular disease. Our studies are important for identifying a link between the severity of alcohol and obesity-related fatty liver disease (i.e., steatohepatitis) and increased risk for cardiovascular disease. Principal areas are focused on understanding how disruption in nitric oxide (NO) and hydrogen sulfide (H2S) signaling, and changes to mitochondria, contribute to pathology (liver disease, cardiovascular disease, and cancer). We are also interested in determining how disruption in cellular circadian rhythms or ‘clocks’ contribute to liver disease.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Bailey SM, Mantena SK, Cakir Y, Chhieng D, Pinkerton KE, and Ballinger SW. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE-/- mouse: implications for a "multi-hit" hypothesis of fatty liver disease. Free Radic Biol Med 46:928-938 (2009). (PMC2775483)  19280709 
Mantena SK, Vaughn Jr DP, Andringa KK, Eccleston HB, King AL, Abrams GA, Doeller JE Kraus DW, Darley-Usmar VM, and Bailey SM. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J 417(1):183-193 (2009). (PMC2637578)  18752470 
Andringa KK, King AL, Eccleston HE, Mantena SK, Landar A, Jhala NC, Dickinson DA, Squadrito GL, and Bailey SM. Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatment: novel molecular targets of disease and hepatoprotection. Am J Physiol Gastrointest Liver Physiol 298(5):G732-745 (2010). (PMC2867419)  20150243 
Oliva CR, Diers A, McClugage SG, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE. Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. J Biol Chem 285(51)39759-67 (2010). (PMC30000957)  20870728 
Bearer CF, Bailey SM, and Hoek JB. Advancing alcohol biomarkers research. Alcohol Clin Exp Res 34(6): 941-945 (2010).  20374221 
Hill BG, Dranka BP, Bailey SM, Lancaster, JR, and Darley-Usmar VM. What part of NO don’t you understand? Some answers to the cardinal questions in nitric oxide biology. J Biol Chem 285(26):19699-19704 (2010).   20410298 
Andringa KK and Bailey SM. Detection of protein thiols in mitochondrial oxidative phosphorylation complexes and associated proteins. Methods Enzymol 474:83-108 (2010).  20609906 
King AL, Swain TM, Dickinson DA, Lesort MJ, and Bailey SM. Chronic ethanol consumption enhances sensitivity to Ca2+-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver. Am J Physiol Gastrointest Liver Physiol 299(4):G954-966 (2010). (PMC2957342)  20651005 
Feldstein AE and Bailey SM. Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxid Redox Signal 15(2):421-424 (2011). (PMC3118602).  21254858 
Eccleston HB, Andringa KK, Betancourt AM, King AL, Mantena SK, Swain, TM, Tinsley HN, Nolte RN, Nagy TR, Abrams GA, and Bailey SM. Chronic exposure to a high fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice. Antioxid Redox Signal 15(2):447-459 (2011). (PMC3118652)  20919931 
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Keywords
Molecular mechanisms of alcohol and obesity induced liver diseases; Mitochondrial dysfunction in disease; Molecular bioenergetics; Circadian biology; Functional proteomics; Nitric oxide; Free radical biology; Toxicology

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