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Faculty Detail Faculty Entry   
Name SELVARANGAN PONNAZHAGAN  
Campus Address SHEL 814 Zip 2182
Phone 205-934-6731
E-mail pons@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:pons@uab.edu">pons@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Medicine  Med - Nephrology Professor
Primary  Pathology   Joint Pathology Professor

Biographical Sketch 
Dr. Ponnazhagan received his BS and MS degrees from the University of Madras and his PhD degree in Genetics from the University of Madras. He completed postdoctoral training at the Indiana University School of Medicine, Indianapolis.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     
American Society for Gene Therapy     
American Society for Microbiology     
 

Research/Clinical Interest
Title
Adeno-associated virus gene therapy
Description
The major research interest of my lab is biology and experimental therapeutics of cancer and bone diseases. I have been working in cancer immunology, osteopenia and cancer bone metastasis for over 10 years and published several papers in these fields. With combined experience in these three inter-related fields, we are currently expanding our research efforts to understand the immune mechanisms of osteolytic cancer metastasis and develop novel treatment methods and test them first in preclinical animal models. Using gene transfer apporaches, our studies focus on anti-angiogenic gene therapy for solid tumors, dendritic cell-based vaccines for cancer immunotherapy, and genetically-engineered stem cell therapy for bone defects. In addition, the lab is also focused on basic biology of adeno-associated virus (AAV) and AAV vector modifications to achieve high-efficiency gene transfer and targeting.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Moore, L.D, Isayeva, T., Siegal, G.P., and Ponnazhagan, S. Silencing of TGF-&#946;1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivo. Clin. Cancer Res. 2008, 14: 4961-4970  18676771 
Hensel JA, Chanda D, Kumar S, Sawant, A., and Ponnazhagan S. LL-37 as a therapeutic target for late stage prostate cancer. Prostate 2011 May;71(6):659-70.   20957672 
Yang, SW, Cody JJ, Rivera, AA, Waehler, R, Wang, M, Kimball, KJ, Alvarez RA, Siegal, GP, Douglas, JT, and Ponnazhagan, S. Conditionally-Replicating Adenovirus Expressing TIMP2 for Ovarian Cancer Therapy. Clin. Cancer Res. 2011, 17:538-549.  21115652 
Triozzi PL, Aldrich W, Ponnazhagan S. Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists. Vaccine. 2010, 28:7837-7843.  20937315 
Kumar, S., Nagy T., and Ponnazhagan, S. Therapeutic potential of genetically modified adult stem cells for osteopenia. Gene Therapy 2010, 17:105-116.   20068549 
Chanda D, Isayeva T, Kumar S, Hensel JA, Sawant A, Ramaswamy G, Siegal GP, and Ponnazhagan, S. Therapeutic potential of adult stem cells for osteolytic bone metastasis. Clin. Cancer Res. 2009, 15:7175-85  19920103 
Isayeva., T., Moore, L.D., Chanda, D., Chen, D., and Ponnazhagan, S. Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status. Prostate 2009,69:1055-66.   19301304 
Ren, C., Kumar S., Diptiman C., and Ponnazhagan, S. Therapeutic potential of mesenchymal stem cells producing IFN-&#945; in a mouse melanoma lung metastasis model. Stem Cells 2008, 9:2332-2338.   18617688 
Kumar S, Ponnazhagan S. Bone homing of mesenchymal stem cells by ectopic alpha 4 integrin expression.FASEB J. 2007 Dec;21(14):3917-27.  17622670  
Isayeva, I., Chanda, D., Eltoum, I-E., and Ponnazhagan, S. Effects of sustained anti-angiogenic therapy in multi-stage prostate cancer in TRAMP mice. Cancer Res. 2007 Jun 15;67(12):5789-97.  17575146  
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