Back to Main

Faculty Detail Faculty Entry   
Name PAUL A GOEPFERT  
Campus Address CCB 328 Zip 2050
Phone 205-975-5667
E-mail paulg@uab.edu" id="FacultyDetail1EmailAddress"><a href="mailto:paulg@uab.edu">paulg@uab.edu</a>
URL
 
 

Department Affiliations(s)
Appointment Type Department Division Rank
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Med - Div of Human Gene Therapy Professor
Primary  Medicine  Med - Infectious Diseases Professor
Secondary  Microbiology  Microbiology Associate Professor

Biographical Sketch 
EMPLOYMENT HISTORY: 2003-Present Associate Professor, Division of Infectious Diseases, Department of Medicine, UAB; 2003-Present Associate Scientist, Gene Therapy Center, UAB; 2003-Present, Associate Professor, Department of Microbiology, UAB; 1998-Present Associate Scientist, Center for AIDS Research, UAB; 1998-2003 Assistant Professor, Department of Microbiology, UAB; 1997-Present Associate Scientist, Comprehensive Cancer Center, UAB; 1997-2003 Assistant Professor, Division of Infectious Diseases, Department of Medicine, UAB; 1996-1997 Clinical Fellow, Division of Infectious Diseaes, Department of Medicine UAB; 1994-1996 Posdoctoral Fellow, Division of Infectious Diseases, Department of Medicine UAB; 1992-1994 Resident, Department of Medicine, UAB; 1991-1992 Intern, Department of Medicine, UAB. AWARDS: 1996 J. Claude Bennett Award for Excellence in Research by a Clinical Associate Fellow, UAB; 1990 Senior AOA Member, Baylor College of Medicine; 1989 High Honors in Basic Science, Baylor College of Medicine; 1987 Outstanding Student in Chemistry

Society Memberships
Organization Name Position Held Org Link
American Association of Immunologists     
American College of Physicians     
American Society of Virology     
Southern Society for Clinical Investigation     
 

Research/Clinical Interest
Title
Determining the mechanisms allowing T cells to control HIV replication in vivo
Description
Paul Goepfert's laboratory concentrates on understanding the immune correlates of protection against HIV disease progression with a focus on cell medicated immune responses (CD4 and CD8 T cells). We are utilizing a variety of techniques in our laboratory to evaluate the quality of HIV-specific T cell responses observed in patients who represent the entire spectra of HIV disease. These assays include an in vitro HIV killing and an in vitro HIV viral suppression assay. These assays measure the actual clearance of virus which has not been the focus of many CD8 T cell assays in the past. Our plan is to use these assays to measure differences in viral clearance among those chronically infected patients with varying degrees of immune control. We would also like to compare these types of responses in acutely infected patients to see how they change over the course of infection. The ultimate goal of this work is to use our findings to aid the development of an effective HIV vaccine to prevent infection and disease progression by more fully understanding correlates of immune control by T cells.

Postdoc Positions Available
Date Posted Position Title
No records
 

Selected Publications 
Publication PUBMEDID
Sabbaj S, Hel Z, Richter HE, Mestecky J, Goepfert PA. Menstrual Blood as a Potential Source of Endometrial Derived CD3+ T Cells. PLoS One 6 (12): e28894, 2011  3235171 
Bansal A, Carlson J, Yan J, Akinsiku O T, Schaefer M, Sabbaj S, Bet A, Levy DN, Heath S, Tang J, Kaslow RA, Walker BD, Ndung'u T, Goulder PJ, Heckerman D, Hunter E, and Goepfert PA. CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription. J Exp Med 207(1):51-59, 2010  2812545 
Goepfert PA, Elizaga ML, Sato A, Qin L, Cardinali M, Hay CM, Hural J, DeRosa SC, DeFawe OD, Tomaras GD, Monefiori DC, Xu Y, Lai L, Kalams S, Baden LR, Frey SE, Blattner WA, Wyatt LS, Moss B and Robinson HL. Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles J Infect Dis 203(5):610-619, 2011  3072720 
Heath SL, Sabbaj S, Bansal A, Kilby JM and Goepfert PA. CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection. AIDS 56(3):213-221, 2011   
Sabbaj S, Pass RF, Pichon S, and Goepfert PA. Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected women. J Infect Dis 203:1534-41, 2011  3096785 
Goepfert, P. A., W. Lumm, P. Farmer, P. Matthews, A. Prendergast, J. M. Carlson, C. A. Derdeyn, J. Tang, R. A. Kaslow, A. Bansal, K. Yusim, D. Heckerman, J. Mulenga, S. Allen, P. J. Goulder, and E. Hunter. 2008. Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients. J Exp Med.  18426987 
Bansal, A., B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert. 2008. Multifunctional T cell characteristics induced by a polyvalent DNA prime/protein boost HIV-1 vaccine regimen given to healthy adults are dependant upon the route and dose of administration. J Virol.  18448544 
Sabbaj S, Heath S, Bansal A, Vohra S, Kilby M, Zajac A, and Goepfert P. Functionally competent antigen-specific CD127hi memory CD8 T cells are only preserved in HIV-infected individuals treated early. J Infect Dis 195:108-117, 2007  17152014 
Yu X, Lichterfeld M, Chetty S, Williams K, Mui S, Miura T, Frahm N, Feeney M, Tang Y, Pereyra F, Labute M, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen T, Rosenberg E, Kiepiela P, Vajpayee M, Goepfert P, Altfeld M, Goulder P, and Walker B. Mutually exclusive T cell receptor induction and differential susceptibility to HIV-1 mutational escape associated with a two amino acid difference between HLA class I subtypes. J Virol 81:1619-1631, 2007  17121793 
Bansal A, Yue L, Conway J, Yusim K, Tang J, Kappes J, Kaslow RA, Wilson CM, and Goepfert P. Immunological control of chronic HIV-1 infection: HLA-mediated immune infection and viral evolution in adolescents. AIDS 21:2387-2397, 2007  18025875 
First Prev   1 2 3 of  3  Next Last  

Keywords

© 2003 University of Alabama School of Medicine. Copyright Information. UAB Disclaimer.
Contact the MEIS Help Desk if you experience problems with this site.