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Faculty Detail    
Name KURT R ZINN
Professor and Director
 
Campus Address VH G082 Zip 0019
Phone 205-975-6414
E-mail kurtzinn@uab.edu
Other websites http://www.uab.edu/medicine/radiology/div-advanced-med-imaging
     

Education
Undergraduate  University of Missouri-Columbia    1981  B.A. Chemistry 
Graduate  University of Missouri-Columbia    1986  M.S. Chemistry 
Graduate  University of Missouri-Columbia    1986  D.V.M. Veterinary Medicine 
Graduate  University of Missouri-Columbia    1992  Ph.D. Biochemistry 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Radiology   Radiology Chair Office Professor
Secondary  Electrical & Computer Engineering  Electrical & Computer Engineering Professor
Secondary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Medicine  Med - Hematology & Oncology Professor
Secondary  Nutrition Sciences   Nutr Sci Biochem Genomics Assistant Professor
Secondary  Pathology   Pathology Chair Office Professor
Secondary  Surgery   Surgery - Otolaryngology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Kurt R. Zinn, D.V.M, M.S., Ph.D., completed his undergraduate studies at the University of Missouri-Columbia (UMC), followed by veterinary school and graduate school at UMC where he earned M.S. (Chemistry) and Ph.D. (Biochemistry) degrees. He joined the UAB Radiology faculty in 1995 after 9 years at the UMC Research Reactor where he developed methods for producing high specific activity radionuclides, including Cu-64.
Dr. Zinn is Director of both the Laboratory of Multimodality Imaging (established 2001) and the Small Animal Imaging Shared Facility (established 2003). He has served as a member of the Radioisotope and Radiation Safety Committee since 1997, and Chair of the committee since 2008. Dr. Zinn serves as Director of Radiology’s Division of Advanced Medical Imaging Research, formed in 2009 in recognition of the department’s expanding research enterprise. He provides oversight for new facilities and infrastructure for PET tracers. Dr. Zinn is a member of the UAB Graduate Faculty and provides research training for M.S. and Ph.D. students.

Society Memberships
Organization Name Position Held Org Link
Society of Nuclear Medicine  Chair, Education Task Force (2009-2011)   
World Molecular Imaging Society     

Research/Clinical Interest
Title
Molecular Imaging
Description
Dr. Zinn's research focuses on the development of molecular imaging approaches for cancer diagnosis and treatment monitoring, and especially technologies that have the potential to translate to human applications. He is actively working on phase I studies and cGMP production of imaging agents.

Selected Publications 
Publication PUBMEDID
Sorace AG, Korb M, Warram JM, Umphrey H, Zinn KR, Rosenthal E, Hoyt K. Ultrasound-stimulated drug delivery for treatment of residual disease after incomplete resection of head and neck cancer. Ultrasound Med Biol 40(4):755-64, 2014.  24412168 
Korb ML, Hartman YE, Kovar J, Zinn KR, Bland KI, Rosenthal EL. Use of monoclonal antibody-IRDye800CW bioconjugates in the resection of breast cancer. J Surg Res 188(1):119-28, 2014.  24360117 
Kim H, Rigell CJ, Zhai G, Lee SK, Samuel SL, Martin A, Umphrey HR, Stockard CR, Beasley TM, Buchsbaum DJ, Li LS, Boothman DA, Zinn KR. Antagonistic Effects of Anti-EMMPRIN Antibody When Combined with Chemotherapy Against Hypovascular Pancreatic Cancers. Mol Imaging Biol 16(1):85-94, 2014.  23836505 
Zhai G, Kim H, Sarver D, Samuel S, Whitworth L, Umphrey H, Oelschlager DK, Beasley TM, Zinn KR. Early therapy assessment of combined anti-DR5 antibody and carboplatin in triple-negative breast cancer models using diffusion-weighted imaging and 1H MR spectroscopy, J Magn Reson Imaging 39(6):1588-94, 2014.  24151215 
Sweeny L, Hartman YE, Zinn KR, Prudent JR, Marshall DJ, Shekhani MS, Rosenthal EL. A novel extracellular drug conjugate significantly inhibits head and neck squamous cell carcinoma. Oral Oncol 49(10):991-7, 2013.  23920309 
Day KE, Beck LN, Deep NL, Kovar J, Zinn KR, Rosenthal EL. Fluorescently labeled therapeutic antibodies for detection of microscopic melanoma. Laryngoscope 123(11):2681-9, 2013.   23616260 
Heath CH, Deep NL, Beck LN, Day KE, Sweeny L, Zinn KR, Huang CC, Rosenthal EL. Use of panitumumab-IRDye800 to image cutaneous head and neck cancer in mice. Otolaryngol Head Neck Surg 148(6):982-90, 2013.  23525846 
Dugger KJ, Chrisman T, Jones B, Chastain P, Watson K, Estell K, Zinn K, Schwiebert L.Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung. Brain Behav Immun 34:67-78, 2013.  23928286 
Rosenthal EL, Zinn KR. Putting Numbers to Fluorescent Guided Surgery. Mol Imaging Biol 15(6): 647-48, 2013.   23836503 
Day KE, Beck LN, Heath H, Huang CC, Zinn KR, Rosenthal EL. Identification of the optimal therapeutic antibody for fluorescent imaging of cutaneous squamous cell carcinoma. Cancer Biol Ther 14(3), 2013.  23298904 
Sorace AG, Warram JM, Mahoney M, Zinn KR, Hoyt K. Enhancement of adenovirus delivery after ultrasound-stimulated therapy in a cancer model. Ultrasound Med Biol 39(12): 2374-81, 2013.  24063960 
Oliver P, LoBuglio A, Zhou T, Forero A, Kim H, Zinn K, Zhai G, Li Y, Lee C, Buchsbaum D. Effect of anti-DR5 and chemotherapy on basal-like breast cancer. Breast Cancer Res Treat 133(2): 417-26, 2012.  21901385 
Kim KH, Dmitriev I, O'Malley JP, Wang M, Saddekni S, You Z, Preuss MA, Harris RD, Aurigemma R, Siegal GP, Zinn KR, Curiel DT, Alvarez RD. A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer. Clin Cancer Res. 18(12):3440-51, 2012.   22510347 
Warram JM, Sorace AG, Saini R, Borovjagin AV, Hoyt K, Zinn KR. Systemic delivery of a breast cancer-detecting adenovirus using targeted microbubbles. Can Gene Ther 19(8):545-52, 2012.  22653385 
Kim H, Folks KD, Guo L, Stockard CR, Fineberg N, Grizzle WE, George JF, Bachsbaum DJ, Morgan DE, Zinn KR. DCE-MRI Detects Early Vascular Response in Breast Tumor Xenografts Following Anti-DR5 Therapy, Mol Imaging Biol 13(1):94-103, 2011.  20383593 
Zinn KR, Anderson CA, Bradbury M, Cutler CS, Peterson TE, Morgan DE, Price JC, Graham MM, Contag CH, Wittstrom K, Norenberg JP Components of a Curriculum for Molecular Imaging Scientists. J Nucl Med 52(4): 50-6, 2011.  21421709 
Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Kappes JC, Zinn KR, Prasain JK, Carroll SL. Tamoxifen Inhibits Malignant Peripheral Nerve Sheath Tumorigenesis via an Estrogen Receptor-Independent Mechanism, Neuro Oncol 1:28-41, 2011  21075781 
Warram JM, Borovjagin AV, and Zinn KR. A genetic strategy for combined screening and localized imaging of breast cancer. Mol Imaging Biol 13(3): 452-61, 2011.  20658194 
Kim H, Folks KD, Guo L, Sellers JC, Fineberg NS, Stockard CR, Grizzle WE, Buchsbaum DJ, Morgan DE, George JF, Zinn KR. Early Therapy Evaluation of Combined Cetuximab and Irinotecan in Orthotopic Pancreatic Tumor Xenografts by Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Molecular Imaging 10:153-167, 2011.  21496446  
Beck BH, Kim HG, Kim H, Samuel S, Liu Z, Shrestha R, Haines H, Zinn K, Lopez RD. Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. Breast Cancer Res Treat, 122(1):135-144, 2010.  19763820 
Borovjagin AV, McNally LR, Wang M, Curiel DT, MacDougall MJ, and Zinn KR, Noninvasive Monitoring of mRFP1- and mCherry-Labeled Oncolytic Adenoviruses in an Orthotopic Breast Cancer Model by Spectral Imaging. Molecular Imaging 9: 59-75, 2010  20236604 
Hoyt K, Warram J, Umphrey H, Belt L, Lockhart M, Robbin M, Zinn, KR. Determination of breast cancer response to antiangiogenic therapy in a murine model using contrast-enhanced ultrasound and artificial neural networks. Journal of Ultrasound in Medicine, 29, 575-583, 2010  20375376 
Chacko BK, Reily C, Srivastava A, Johnson MS, Ulasova E, Agarwal A, Zinn K, Murphy MP, Kalyanaraman B, Darley-Usmar V Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy Mito Q., Biochem 432(1):9-19, 2010  20825366 
Kim H, Chen J, Zinn KR, Hubbard WJ, Fineberg NS, Chaudry IH. Single photon emission computed tomography demonstrated efficacy of 17beta-estadiol therapy in male rats after trauma-hemorrhage and extended hypotension, J Trauma 69(5):1266-73, 2010  20571453 
Helman EE, Newman JR, Dean NR, Zhang W, Zinn KR, Rosenthal EL. Optical imaging predicts tumor response to anti-EGFR therapy, Cancer Biol Ther 10(2):166-71, 2010.  20505368 
Zinn KR, Chaudhuri TR, Szafran AA, O'Quinn D, Weaver C, Dugger K, Lamar D, Kesterson RA, Wang X, Frank SJ. Noninvasive bioluminescence imaging in small animals. ILAR J 49 (1): 103-15, 2008.  18172337 

Keywords
Molecular Imaging, preclinical animal models, clinical imaging