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Faculty Detail    
Name LUFANG ZHOU
 
Campus Address ZRB 306 Zip 0006
Phone 205-975-3764
E-mail lfzhou@uab.edu
Other websites Cardiovascular Disease profile
CSCB Laboratory Website
     

Education
Undergraduate  Tianjin University     1997  BS 
Graduate  Tianjin University     2000  MS 
Graduate  Case Western Reserve University    2006  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Assistant Professor
Secondary  Biomedical Engineering  Biomedical Engineering Assistant Professor
Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Assistant Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Assistant Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Genetics and Genomic Sciences 
Immunology 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Zhou received his PhD in Biomedical Engineering from Case Western Reserve University in 2006. He then completed the postdoctoral training in Professor the Johns Hopkins University School of Medicine prior to joining UAB as a faculty member in the Department of Medicine, Division of Cardiovascular Disease in 2011. Dr. Zhou earned his MS in 2000 and BS in 1997, both from Tianjin University.

Society Memberships
Organization Name Position Held Org Link
America Heart Association   Member   
American Physiology Society  Member   
Biomedical Engineering Society   Member   
Biophysical Society  Member   

Research/Clinical Interest
Title
Mitochondrial dysfunction and oxidative stress in human disease
Description
Dr. Zhou's research interests are in the area of pathophysiology and therapeutics of oxidative stress related to diseases of mitochondrial origin as it pertains to human diseases (such as cardiovascular disease, cancer and diabetes). He is also interested in developing novel optogenetic-based research and therapeutic strategies. For details please contact Dr. Zhou at lfzhou@uab.edu or visit the lab website at http://www.uab.edu/cscb/.

Positions Available
Date Posted Position Title
12/5/2014  Postdoctoral Fellow  
A postdoctoral position in the Comprehensive Cardiovascular Center and Division of Cardiovascular Disease, School of Medicine at the University of Alabama at Birmingham (UAB) is available immediately. The position involves development and application of multi-scale computational models for the study of complex cardiac mechanical, metabolic, and electrophysiological systems. The overall goal of this project is to understand the role of mitochondrial dysfunction and associated oxidative stress in the development of cardiac diseases such as ventricular arrhythmias and sudden cardiac death. Due to the interdisciplinary nature of the research, the successful candidate will have the opportunities to learn and perform in vitro/in vivo experiments such as patch clamp and optical mapping in the PI and/or the collaborator’s laboratories for model validation and hypothesis testing.

Qualifications include PhD in biomedical engineering or other relevant areas of engineering and biomedical sciences. The ideal candidates should have strong research background in computer modeling and simulation of biological systems with interests in cardiovascular disease and computational method developments. Previous experience in scientific programming, computational modeling, continuum model (such as Finite Element Method), or parallel computing, and familiarity with UNIX/Linux operating system are highly desirable. Working experience in cardiac electrophysiology and high-resolution imaging is plus. Salary will be commensurate with experience and qualification.

UAB is a major research university and academic health center that discovers, teaches and applies knowledge for the intellectual, cultural, social and economic benefit of Birmingham, the state and the nation. The UAB faculty is renowned for its excellence in interdisciplinary research programs. For application, please e-mail your current curriculum vitae, statement of research accomplishments and interests, career goals, and names and contact information of three references to Lufang Zhou, Ph.D. at lfzhou@uab.edu.

UAB is an Equal Opportunity/Affirmative Action employer.   
12/5/2014  Graduate Student  
1-2 PhD student positions are available immediately. The student could choose to join any of the following GBS themes: Biomedical Engineering; Cell, Molecular & Developmental Biology; Pathology & Molecular Medicine; Cancer Biology; Genetics Genomics and Bioinformatics.   

Selected Publications 
Publication PUBMEDID
Liu J, Wang P, Zou L, Qu J, Litovsky SH, Umeda PK, Zhou L, Chatham JC, Marsh SA, Dell'Italia LJ, Lloyd SG. High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats. Am J Physiol Heart Circ Physiol. 2014 15;307(4):H598-608.  24929857 
Ma C, Kojimab K, Xu N, Mobley J, Zhou L, Yang ST, and Liu XM. Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum. J Biotechnol. In press  25449011 
Zhou L, Xu N, Sun Y, Liu XM. Targeted biopharmaceuticals for cancer treatment. Cancer Letters, 2014, 1;352(2):145-51  25016064 
Zhou L*. Optogenetic pacing for resynchronization therapy of heart failure. Austin J Biomed Eng. 2014;1(3):2   
Li Q, Pogwizd SM, Prabhu SD, Zhou L*. Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in Guinea pig cardiomyocytes. PLoS One. 2014 10;9(4):e93928  24722410 
Collins HE, He L, Zou L, Qu J, Zhou L, Litovsky SH, Yang Q, Young ME, Marchase RB, Chatham JC. Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Am J Physiol Heart Circ Physiol. 2014 15;306(8):H1231-9.  24585777 
Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O'Rourke B. Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol. 2014 7(1):143-51.  24382411 
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI,Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal. 2013 10;19(11):1185-97.  23919584 
Zhou L and O’Rourke B. "Cardiac mitochondrial network excitability: insights from computational
analysis". Am J Physiol Heart Circ Physiol 302: H2178-89, 2012.  
22427517 
Zhou L, Aon MA, Ting Liu, and O’Rourke B. “Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.” J Mol Cell Cardiol. 2011 Nov;51(5):632-9 (Highlighted Article).  21645518 
Zhou L, Aon M, Tabish A, Cortassa S, Winslow R and O’Rourke B. “A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.” PLoS Comput Biol 6(1): e1000657. doi:10.1371/journal.pcbi.1000657, 2010.  20126535 
Zhou L, Cortassa S, Wei AC, Aon MA, Winslow R and O’Rourke B. “Modeling cardiac action potential shortening driven by ROS-Induced mitochondrial oscillations in guinea pig cardiomyocyte.” Biophysical J, 97(7):1843-1853, 2009.  19804714 
Zhou L, Huang H, McElfresh TA, Prosdocimo T, and Stanley WC. “Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.” Am J Physiol Heart Circ Physiol, 295(3):H939-45, 2008  18660443 
Plank G, Zhou L, Greenstein J, Cortassa S, Winslow R, O’Rourke B and Trayanova N. “From mitochondrial ionic channels to arrhythmias in the heart.” Philos Transact A Math Phys Eng Sci, 366(1879):3381-409, 2008.   18603526 
Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, and Yu X. “Analysis and prediction of cardiac metabolism and transport: role of malate-aspartate shuttle.” J of Theor Bio, 254(2):466-75, 2008.  18603266 
Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, and Stanley WC. “Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.” Am J Physiol Heart Circ Physiol, 294(2): H954-60, 2008.   18083904 
Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, and Stanley WC. “Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation.” J Physiol (Lond), 579, 811-21, 2007  17185335 
Zhou L, Cabrera ME, Okere IC, Sharma N, and Stanley WC. “Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.” Am J Physiol Heart Circ Physiol, 291: H1036-H1046, 2006.   16603683 
Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. “Lactate production at the onset of ischemia is regulated by glycolysis and the transfer of NADH into mitochondria independent of mitochondrial NADH/NAD+: insights from in silico studies.” J Physiol (Lond), 569: 925-937, 2005.  16223766 
Zhou L, Salem JE, Saidel GM, Stanley WC, and Cabrera ME. “Mechanistic model of cardiac energy metabolism predicts localization of glycosis to cytosolic sub-domain during ischemia.” Am J Physiol Heart Circ Physiol, 288: H2400-H2411, 2005.   15681693 
Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L and O’Rourke B. “From mitochondrial dynamics to arrhythmias.” Int J Biochem Cell Biol. 41(10): 1940-1948, 2009.  19703656 

Keywords
mitochondrial biology, cardiovascular disease, multiscale computational modeling, live cell imaging, optogenetics