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Faculty Detail    
Campus Address ZRB 306 Zip 0006
Phone 205-975-3764
Other websites

Undergraduate  Tianjin University     1997  BS 
Graduate  Tianjin University     2000  MS 
Graduate  Case Western Reserve University    2006  PhD 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Assistant Professor
Secondary  Biomedical Engineering  Biomedical Engineering Assistant Professor
Center  Comprehensive Cardiovascular Ctr  Comprehensive Cardiovascular Ctr Assistant Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Assistant Professor

Biographical Sketch 
Dr. Zhou received his PhD in Biomedical Engineering from Case Western Reserve University in 2006. He then completed the postdoctoral training in Professor the Johns Hopkins University School of Medicine prior to joining UAB as a faculty member in the Department of Medicine, Division of Cardiovascular Disease in 2011. Dr. Zhou earned his MS in 2000 and BS in 1997, both from Tianjin University.

Society Memberships
Organization Name Position Held Org Link
America Heart Association   Member   
Biomedical Engineering Society   Member   
Biophysical Society  Member   

Research/Clinical Interest
Oxidative stres, mitochondrial dysfunction and cardiac disease
Dr. Zhou's research interests are in the area of pathophysiology and therapeutics of oxidative stress related to diseases of mitochondrial origin as it pertains to cardiovascular and metabolic diseases. He is also interested in developing optogenetic-based research and therapeutic strategies.

Selected Publications 
Publication PUBMEDID
Zhou L and O’Rourke B. "Cardiac mitochondrial network excitability: insights from computational
analysis". Am J Physiol Heart Circ Physiol 302: H2178-89, 2012.  
Zhou L, Aon MA, Ting Liu, and O’Rourke B. “Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.” J Mol Cell Cardiol. 2011 Nov;51(5):632-9 (Highlighted Article).  21645518 
Zhou L, Aon M, Tabish A, Cortassa S, Winslow R and O’Rourke B. “A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.” PLoS Comput Biol 6(1): e1000657. doi:10.1371/journal.pcbi.1000657, 2010.  20126535 
Zhou L, Cortassa S, Wei AC, Aon MA, Winslow R and O’Rourke B. “Modeling cardiac action potential shortening driven by ROS-Induced mitochondrial oscillations in guinea pig cardiomyocyte.” Biophysical J, 97(7):1843-1853, 2009.  19804714 
Zhou L, Huang H, McElfresh TA, Prosdocimo T, and Stanley WC. “Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.” Am J Physiol Heart Circ Physiol, 295(3):H939-45, 2008  18660443 
Plank G, Zhou L, Greenstein J, Cortassa S, Winslow R, O’Rourke B and Trayanova N. “From mitochondrial ionic channels to arrhythmias in the heart.” Philos Transact A Math Phys Eng Sci, 366(1879):3381-409, 2008.   18603526 
Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, and Yu X. “Analysis and prediction of cardiac metabolism and transport: role of malate-aspartate shuttle.” J of Theor Bio, 254(2):466-75, 2008.  18603266 
Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, and Stanley WC. “Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.” Am J Physiol Heart Circ Physiol, 294(2): H954-60, 2008.   18083904 
Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, and Stanley WC. “Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation.” J Physiol (Lond), 579, 811-21, 2007  17185335 
Zhou L, Cabrera ME, Okere IC, Sharma N, and Stanley WC. “Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.” Am J Physiol Heart Circ Physiol, 291: H1036-H1046, 2006.   16603683 
Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. “Lactate production at the onset of ischemia is regulated by glycolysis and the transfer of NADH into mitochondria independent of mitochondrial NADH/NAD+: insights from in silico studies.” J Physiol (Lond), 569: 925-937, 2005.  16223766 
Zhou L, Salem JE, Saidel GM, Stanley WC, and Cabrera ME. “Mechanistic model of cardiac energy metabolism predicts localization of glycosis to cytosolic sub-domain during ischemia.” Am J Physiol Heart Circ Physiol, 288: H2400-H2411, 2005.   15681693 
Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L and O’Rourke B. “From mitochondrial dynamics to arrhythmias.” Int J Biochem Cell Biol. 41(10): 1940-1948, 2009.   

mitochondrial biology, cardiovascular disease, computational modeling, live cell imaging, optogenetics