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Faculty Detail    
Name J MICHAEL WYSS
Professor
Director Center for Coummunity OutReach Development
 
Campus Address THT 946 Zip 0006
Phone 205-934-6086
E-mail jmwyss@uab.edu
Other websites http://main.uab.edu/show.asp?durki=8048
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Medicine  Med - Cardiovascular Disease Professor
Secondary  Neurobiology  Neurobiology Professor
Center  Neurology   Alzheimer's Disease Center Professor
Center  Center for Aging  COMPREHENSIVE CTR FOR HEALTHY AGING Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor
Center  Medicine  Ctr Cardiovasc Bio Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 
Integrative Genetics Graduate Program 
Medical Scientist Training Program 
Neuroscience 
Neuroscience Graduate Program 
Neurosciences 

Biographical Sketch 
Dr. J. Michael Wyss (b. 1948), Professor (Cell Biology, Medicine, Neurobiology and Psychology) and Director (Center for Community OutReach Development), completed his undergraduate studies in neurobiology at Concordia College, Indiana (B.S., 1970), and received a Ph.D. in neurobiology from Washington University (St. Louis) in 1976. During his postdoctoral studies at Washington University School of Medicine he applied cell biological methods to elucidate the role of the limbic cortex in behavior and autonomic control, and has continued to expand this research at Birmingham (1979-present). His work on the central control of the autonomic nervous system has propelled him into the studies of the neurocellular mechanisms controlling arterial pressure. Outside of the laboratory he enjoys swimming, soccer and photography.

Society Memberships
Organization Name Position Held Org Link
AAALAC, International  Member of Council   
American Physiological Society  Member of Council   
Society for Neuroscience     

Research/Clinical Interest
Title
Neuroplasticity in aging and neuro cardiovascular control
Description
Michael Wyss is Director of the UAB Center for Community Outreach Development (CORD), and thereby directs much of the University’s K-12 STEM education outreach, and he developed several new programs and expanded previously successful programs. Further, Dr. Wyss has formed outstanding alliances with all of the area school districts. Dr. Wyss has focused CORD on empowering K-12 science, math and technology education, especially for underrepresented and minority students, in large part, by providing their teachers the requisite knowledge base and effective, inquiry-based tools to educate their students. Dr. Wyss’s biomedical research focuses on two major areas. The first research focus is on neuronal plasticity and grows out of his studies demonstrating that a specific group of pyramidal neurons in the rat retrosplenial cortex displays a dramatic alteration in their structure as the animal ages. Concurrent with these changes in structure, they have demonstrated that cellular, molecular and behavioral changes occur, including a significant decrease in spatially learning. The second research focus is on the mechanisms by which the hypothalamus regulates blood pressure in salt-sensitive individuals. This work has recently focused on the ability of polyphenols to blunt hypertension. These studies employ cellular and molecular techniques, transgenic manipulations in mouse, neural recordings, nerve pathway tracing and plasticity measures, biochemical analyses, MS/MS, FRAP/FRET, etc. This work is currently most focused on the ability of puerarin to blunt metabolic disease components, especially the ability of this polyphenol to regulate lipid metabolism and insulin sensitivity.

Selected Publications 
Publication PUBMEDID
Vitturi, D.A., C. Sun, V. Harper, B. Thrash-Williams, N. Cantu-Medellin, B. Chacko, N. Peng, Y. Dai, J. M. Wyss, T. Townes, R.P. Patel. Antioxidant functions for the hemoglobin beta 93 cysteine residue in erythrocytes and in the vascular compartment in vivo. Free Radical Biology and Medicine, 16:119-129, 2012.  23159546 
Prasain, J.K., N. Peng, R. Rajbhandari, J. M. Wyss. The Chinese Pueraria root extract (Pueraria lobota) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomedicine, 20:17– 23, 2012.   23123226 
Jirakulsomchoka D, N. Soikhama, N. Kunbootsria, P. Wannanonda, T. Suttituma, T. Tongoona, S. Roysommuti and J.M. Wyss. Impaired renal response to portal infusion of hypertonic saline in adriamycin-treated rats. Clin Exp Pharmacol Physiol. 39:636-41, 2012. PMID:22564274Roysommuti, S. and Wyss, J.M. Perinatal taurine exposure on infants. Clinical Medicine, 15:17--28, 2012.  23070226 
Roysommuti, S. and Wyss, J.M. Perinatal taurine exposure on infants. Clinical Medicine, 15:17--28, 2012.   23070226 
Roysommuti S, P. Malila, D. Jirakulsomchok and J.M. Wyss. Adult renal function is modified by perinatal taurine status in conscious male rats. J Biomed Sci, 17:1-7, 2010.  20804607 
Roysommuti S, P. Malila, W. Lerdweeraphon, D. Jirakulsomchok, and J.M.Wyss. Perinatal taurine exposure alters renal potassium excretion mechanisms in adult conscious rats. J Biomed Sci, 17:21-31, 2010.   20804604 
Prasain, J,K., N. Peng, R. Moore, A. Arabshahi, S. Barnes, J.M. Wyss. Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry. Phytomedicine. 16:65-67, 2009.   19027277 

Keywords
Alzheimers, hypertension, neuronal plasticity, behavior, blood pressure, botanicals, STEM education