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Faculty Detail    
Name QIN WANG
Associate Professor
 
Campus Address MCLM 986 Zip 0005
Phone 205-996-5099
E-mail qinwang@uab.edu
Other websites
     

Education
Medical School  Beijing Medical University    1992  MD 
Graduate  University of Iowa    1999  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Neurobiology  Neurobiology Associate Professor
Center  Medicine  Comprehensive Diabetes Ctr Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Integrative Biomedical Sciences 
Neuroscience 
Neuroscience Graduate Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Qin Wang received her M.D. degree from Beijing Medical University, China. After traveling to the US, she obtained her Ph.D. degree in December 1999 from University of Iowa. She then did her postdoc work at Vanderbilt University, where she was appointed as a Research Assistant Professor two years later. In June 2005, Dr. Wang joined the Department of Physiology and Biophysics as an Assistant Professor.

Society Memberships
Organization Name Position Held Org Link
American Heart Association     
American Physiology Society     
American Society for Pharmacology and Experimental Therapeutics     

Research/Clinical Interest
Title
Regulation of GPCR trafficking, signaling and in vivo functions
Description
The long term goal of our research is to reveal novel regulatory pathways controlling G protein-coupled receptors (GPCRs) functions at the molecular and cellular levels and to understand how these regulatory mechanisms influence GPCR-elicited physiological functions in vivo, so as to provide new insights for therapeutic strategies. Current projects include: 1) regulation of alpha2A adrenergic receptor trafficking and signaling in native neurons exploiting gene knock-in and knock-out mice; 2) regulation of adenosine-mediated synaptic plasticity and behavior; 3) functions of the alpha2A adrenergic receptor in neurodegenerative diseases.

Selected Publications 
Publication PUBMEDID
Cottingham C, Lu R, Jiao K and Wang Q (2013) Cross-talk from  adrenergic receptors modulates alpha2A adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin. J Biol Chem., 288, 29193-29205.
 
 
De Fusco M, Vago R, Striano P, Di Bonaventura C, Zara F, Mei D, Kim MS, Muallem S, Chen Y, Wang Q, Guerrini R and Casari G (2013) The alpha2B adrenergic receptor is mutant in cortical myoclonus and epilepsy. Ann. Neurol. E-pub Oct 1, 2013.
 
 
Cottingham C and Wang Q (2012). Alpha2 adrenergic receptor dysregulation in depressive
disorders: implications for depressive neurobiology and antidepressant therapy. Neurosci
Biobehav Rev. 36, 2214-2225. 
 
Cottingham C, Jones A and Wang Q (2012) Desipramine selectively potentiates
norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Biochem Biophys Res Commun. 420, 161-165. 
 
Cottingham C, Li X and Wang Q (2012) Noradrenergic antidepressant responses in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology 62, 2353-2361.   
Chen Y, Liu Y, Cottingham C, McMahon L, Jiao K, Greengard P and Wang Q (2012) Neurabin scaffolding of the adenosine receptor and RGS4 regulates anti-seizure effect of adenosine. J Neurosci., 32, 2683-2695. (Commentary on Purinergic signal. 2012, 8:659; Highlighted on Nature SciBX: Science-Business eXchange, and on Global Medical
Discovery). 
 
Cottingham C, Chen H, Chen Y, Peng Y and Wang Q (2011). Genetic variations of alpha2 adrenergic receptors illuminate the diversity of receptor functions. Curr Top Membr. 67, 161-190.   
Cottingham C, Chen Y, Jiao K and Wang Q (2011) Desipramine is an arrestin-biased ligand at the alpha 2A adrenergic receptor driving receptor downregulation in vitro and in vivo. J Biol Chem., 286, 36063-36075. (Highlighted in Faculty of 1000).   
DeBenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K (2011) Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem Biophys Res Commun. 409, 338-343.   
Nie X, Brown B, Wang Q and Jiao K (2010) Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs. 193, 393-403.    
Lu R, Chen Y, Peng N, Jiao K, Limbird LE, Wyss JM and Wang Q (2010) Hypnotic and hypotensive responses to alpha2-adrengergic agent are potentiated and accompanied by enhanced G protein coupling to the receptor in spinophilin null mice. Mol. Pharm. 78, 279-286.   
Shields AD, Wang Q, Winder DG (2009) Alpha2A-Adrenergic Receptors Heterosynaptically Regulate Glutamatergic and GABAergic transmission in the BNST. Neuroscience, 163, 339-351.    
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q (2009) Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. J Biol Chem., 284, 13233-13243.   
Nag S, Wang Q, Limbird LE, Mokha SS (2008) Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behav Brain Res., 197, 457-461.   
Xu J, Chen Y, Lu R, Cottingham C, Jiao K and Wang Q (2008) PKA phosphorylation of spinophilin modulates its interaction with the alpha2AAR and alters temporal properties of alpha2AAR internalization. J Biol Chem., 283, 14516-14523.   
Nie X, Deng CX, Wang Q, Jiao K (2008) Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev. Biol. 316, 417-430.   
Song L, Yan W, Chen X, Deng CX, Wang Q and Jiao K (2007) Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ. Res., 101, 277-285.   
Wang Q and Limbird LE (2007) Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochem Pharmacol. 73, 1135-1145. (Wang Q. is the corresponding author).   
Wang Q, Roujian Lu, Zhao J and Limbird LE (2006) Arrestin determines the temporal and spatial activation G-protein-mediated ERK by endogenous alpha2-adrenergic receptors. J Biol Chem., 281, 25948-25955. (Wang Q. is the corresponding author).   
Brady AE, Wang Q, Rizzo M, Greengard P and Limbird LE (2005) Alpha2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha2A-subtype. Mol Pharm. 67, 1690-1696. (Wang Q. is the corresponding author).   
Brady AE, Wang Q, Limbird LE (2004) Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods Mol Biol., 259, 371-378.   
Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P and Limbird LE (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
Science 304, 1940-1944 (Research Article, highlighted in Faculty of 1000). 
 
Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P and Limbird LE (2003) Spinophilin stabilizes cell surface expression of alpha2B-adrenergic receptors. J Biol Chem 278, 32405-32412.   
Wang Q and Limbird LE (2002) Regulated interactions of the alpha2A-adrenergic receptor with spinophilin, 14-3-3 zeta, and arrestin 3. J Biol Chem 277, 50589-50596.   

Keywords
GPCR, trafficking, ligand-selective, interacting proteins, adenosine, adrenergic, neuroprotection