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Faculty Detail    
Name MASAKO SHIMAMURA
 
Campus Address CHB 114 Zip 0011
Phone 205-996-7764
E-mail mshimamura@uab.edu
Other websites
     

Education
Undergraduate  Cornell University, Ithica, NY, Summa Cum Laude    1987  BA 
Medical School  The Johns Hopkins School of Medicine    1991  MD 
Residency  University of Washington Affiliated Hospitals, Seattle WA    1994  Residency 
Fellowship  UAB Pediatric Infectious Diseases     2001  Pediatric Infectious Diseases Postdoctoral Fellowship 

Certifications
American Board of Pediatrics, General Pediatrics  1994 
American Board of Pediatrics, Pediatric Infectious Diseases  2001 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pediatrics   Ped - Infectious Disease Associate Professor
Center  Medicine  Nephrology Res & Trng Ctr Associate Professor

Society Memberships
Organization Name Position Held Org Link
American Society of Microbiology     
American Society of Transplantation, Transplant Infectious Diseases Community of Practice     
Association for Pediatric Program Directors     
Infectious Diseases Society of America, Transplant and Compromised Host Interest Group     
Pediatric Infectious Diseases Society     
Society for Pediatric Research     
The Transplantation Society, Transplant Infectious Diseases section     
UAB Biomatrix Engineering and Regenerative Medicine Center     
UAB Nephrology Research and Training Center     
UAB O’Brien Center for Acute Kidney Injury Studies     

Research/Clinical Interest
Title
Description
My major research interest is the study of cytomegalovirus (CMV) in transplantation, for which I have developed in-vitro and murine renal transplant models. The in-vitro studies investigate mechanisms by which CMV infection of renal epithelial cells dysregulates signaling pathways resulting in production of fibrogenic cytokines and extracellular matrix, potentially contributing to allograft fibrosis and late graft loss. In-vivo models focus upon host-virus immunologic interactions, allograft fibrosis, and the role of antivirals in virus-induced allograft injury. I have also developed a clinical database for pediatric solid organ transplant recipients through which we are analyzing clinical correlates of persistent CMV and EBV viremia, and are currently expanding these studies to interrogate peripheral blood, clinical biopsy tissues, and viral DNA sequences for host and viral characteristics associated with viremia and outcomes. I also collaborate with colleagues studying congenital CMV infection in clinical populations and murine models, and with investigators studying mechanisms of CMV colitis in inflammatory bowel disease. These collaborations expand upon my research interest in viral infections of the immunocompromised host. Clinically I have established a Pediatric Transplant Infectious Diseases service at UAB with clinical affiliations with the pediatric and adult solid organ transplant (SOT) groups, as well as the UAB Transplant Institute. As part of these collaborations, I have spearheaded an HSF GEF Clinical Care Initiative application to study disparities in pediatric transplant access and outcome, encompassing not only the SOT groups but also collaborators in the Department of Biostatistics (School of Public Health), the Minority Health and Health Disparities Research Center, and the Center for Clinical and Translational Sciences. We are currently assembling other collaborative grant applications to fund research endeavors to improve the care of pediatric solid organ transplant recipients. I am also now working to establish research projects with the pediatric and adult Stem Cell Transplant groups at UAB.