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Faculty Detail    
Name GWENDALYN D KING
 
Campus Address SHEL 913 Zip 2182
Phone 205-996-6247
E-mail gdking@uab.edu
Other websites Department website
Lab website
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurobiology  Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  Center for Aging  COMPREHENSIVE CTR FOR HEALTHY AGING Assistant Professor
Center  Civitan International Research Center  Civitan International Research Center Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
BS, Purdue University
MS, Ph.D. University of Michigan
Postdoctoral Fellow, Cedars-Sinai Medical Center/UCLA
Instructor, Boston University School of Medicine

Research/Clinical Interest
Title
Age regulating protein function in the brain
Description
We are interested in understanding the differences between normal and pathological brain aging. Present studies are focused on dissecting the role of Klotho in the brain and in the aging process. We are examining regulation of gene expression pre and post-transcriptional, protein distribution, localization and function in the brain, and Klotho's role in glioma.

Selected Publications 
Publication PUBMEDID
Muhammad AKM, Candolfi M, King GD, Yagiz K, Foulad D, Mineharu Y, Kroeger KM, Treuer KA, Nichols WS, Sandersen NS, Yang J, Khayznikof, M, Van Rooijen N, Lowenstein PR, Castro MG. Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression. Clinical Cancer Research (2009) 15(19):6113-6127  19789315 
King GD, Muhammad AKM, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. High-capacity adenoviral vector-mediated anti-glioma gene therapy in the presence of systemic anti-adenovirus immunity. Journal of Virology (2008) 82(9):4680-4.   18287240 
King GD, , Kroeger KM, Bresee CJ, Candolfi M, Liu C, Manalo CM, Muhammad AKM, Pechnick RN, Lowenstein PR, Castro MG. Flt3L in combination with HSV1-TK- mediated gene therapy reverses brain tumor-induced behavioral deficits. Molecular Therapy (2008) 16(4):682-90.   18283279 
Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG. Flt3 ligand recruits plasmacytoid dendritic cells to the brain. Journal of Immunology (2006) 176: 3566 – 3577.   16517725 
King GD*, Curtin JF*, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. Gene Therapy and Targeted Toxins for Glioma. Current Gene Therapy (2005) 5:535-557. PMID:   16457645 
Curtin JF*, King GD*, Candolfi M, Greeno RB, Kroeger KM, Lowenstein PR, Castro MG. Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current Topics in Medicinal Chemistry (2005) 5(12):1151-70.   16248789 
Ali S*, King GD*, Curtin JF, , Xiong W, Puntel M, Liu C, Cheng Q, Prieto J, Lassmann H, Lowenstein PR, Castro MG. Combined immune-stimulation and conditional cytotoxic gene therapy provide long-term survival in a macroscopic glioma model. Cancer Research, (2005) 65 (16) :7194-204.   16103070 
King GD, Cherian K, Turner RS. X11α impairs γ- but not β-secretase cleavage of Amyloid Precursor Protein. Journal of Neurochemistry, (2005) 88 (4):971-82.   14756819 
King GD, Turner RS. Adaptor protein interactions: modulators of Amyloid Precursor Protein metabolism and Alzheimer’s disease risk? Experimental Neurology. (2004)185: 208-19.   14736502 
King GD, Perez RG, Steinhilb ML, Gaut JR, Turner RS. X11α modulates secretory and endocytic metabolism of the Amyloid Precursor Protein. Neuroscience. (2003)120, 143-154. PMID:   12849748  
King GD, Muhammad AKM, CurtinJF, Barcia C, Puntel M, Liu C, Candolfi M, Honig SB, Mondkar S, Lowenstein PR, Castro MG. Flt3L and HSV1-TK eradicate multifocal glioma in a syngeneic glioblastoma model. Neuro-oncology; (2008) 10(1):19-31.   18079358 
King GD, Huang MM, Schuman ER, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules to modulate transcription of Klotho. Under review   
King GD, Muhammad AKM, Laroque D, Liu C, Kroeger KM, Castro MG, Lowenstein PR. Flt3L and TK gene therapy induces immunological surveillance that mediates a specific immune response against a brain tumor neo-antigen. Molecular Therapy, 2011 In press.   
King GD, Rosene DL, Abraham CR. Promoter methylation and age-related downregulation of klotho in rhesus monkey. Under review   

Keywords
age, brain, klotho, glioma, molecular biology