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Faculty Detail    
Name DAVID O. FREEDMAN
 
Campus Address BBRB 201 Zip 2170
Phone 205-934-1630
E-mail freedman@uab.edu
Other websites http://gorgas.dom.uab.edu/
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Infectious Diseases Professor
Secondary  Epidemiology  Epidemiology Professor

Biographical Sketch 
BSc, First Class Honors in Physiology, McGill, 1977. MD Toronto, 1981. Fellowship in immunoparasitology NIH 1985-9. Certified in Infectious Diseases by ABIM and the Royal College of Physicians of Canada. UAB Division of Geographic Medicine 1989-2006; Division of Infectious Diseases 2006-present. Profess of Epidemiology, UAB School of Public Health. Director UAB Travelers Health Clinic. Member VA Merit Review Infectious Diseases Study Section, 1997-2000. Chair Advisory Panel on Parasitic Diseases of the US Pharmacopeia 1995-2000. Funded research projects have been completed in India, Guatemala, Ghana, Brazil, and Peru in addition to the 23 countries where GeoSentinel sites are located.

Society Memberships
Organization Name Position Held Org Link
American Society of Tropical Medicine and Hygiene  President, Clinical Sub-Group 2003-5  http://www.astmh.org 
Infectious Diseases Society of America  Fellow, Member Scientific Program Committee 2002-5  http://www.idsociety.org 
International Society of Travel Medicine  Secretary-Treasurer  http://www.istm.org 
Royal College of Physicians and Surgeons of Glasgow  Fellow, Faculty of Travel Medicine   
The Gorgas Course in Clinical Tropical Medicine  Director  http://gorgas.dom.uab.edu/ 
World Health Organization--International Health Regulations   Roster of Experts, Expert in Travel Medicine  http://www.who.int/ihr/en/ 

Research/Clinical Interest
Title
Clinical Tropical Medicine and Travelers Health; BioSurveillance
Description
1) Development of global provider-based surveillance networks for characterization of infectious disease morbidity in travelers and migrants using innovative electronic communications modalities. Director of GeoSentinel, a CDC-funded global surveillance network of 50 travel/tropical medicine units on 6 continents. 2) Development of novel techniques for the clinical teaching of tropical medicine to graduate physicians from industrialized countries, on-site in the tropics while maintaining all traditional accreditation standards. Director of the Gorgas Courses in Clinical Tropical in Lima, Peru with 50 participants/years from 12-20 countries. 3) Development of novel strategies to track global trends in disease and occupational health risk among employees of multinational corporations.

Selected Publications 
Publication PUBMEDID
Arguin PM, Marano N, Freedman DO. Globally mobile populations and the spread of emerging pathogens [editorial]. Emerg Infect Dis 2009; 15:1713-14.   
Gautret P, Clerinx J, Caumes E, Simon F, Jensenius M, Loutan L, Schlagenhauf P, Castelli F, Freedman D et al. Imported Human African Trypanosomiasis in Europe, 2005-2009. Eurosurveillance 2009; 14:1-6.    
Marano C and Freedman DO. Global Health Surveillance and Travelers’ Health. Curr Opin Infect Dis 2009; 22:423-9.   
Freedman DO. Protection of Travelers (Ch. 329) and Infections in Returning Travelers (Ch. 330). IN: Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 7th Edition. Elsevier. 2009. Pp 4009-17.   
Burchard GD, Caumes E, Connor BA, Freedman DO, et al. Expert Opinion on Vaccination of Travelers Against Japanese Encephalitis. J Travel Med 2009; 16: 204-16.   
Freedman DO. Clinical practice. Malaria prevention in short-term travelers. N Engl J Med. 2008;359:603-12 .    
Schwartz E, Weld L, Wilder-Smith A, von Sonnenburg F, Keystone JS, Kain KC, Torresi J, and Freedman DO for the GeoSentinel Surveillance Network. Seasonality, Annual Trends, and Characteristics of Dengue in Ill Returned Travelers. Emerg Infect Dis 2008;14: 1081-88   
Strikas RA, Kozarsky PE, Reed C, Kapella BK, Freedman DO. Should Healthcare Providers in the United States have Access to Influenza Vaccines Formulated for the Southern Hemisphere. J Travel Med 2008;15: 449-53.   
Nicolls DJ, Weld LH, Schwartz E, Reed C, Sonnenburg F, Freedman DO, Kozarsky PE. Characteristics of Schistosomiasis in Travelers Reported to the GeoSentinel Surveillance Network 1997-2008. Am J Trop Med Hyg 2008; 79:729-34.   
Davis XM, MacDonald S, Borwein S, Freedman DO, Kozarsky PE, von Sonnenburg F, Keystone JS, Lim PL, Marano N. Health Risks in Travelers to China: The GeoSentinel Experience and Implications for the 2008 Beijing Olympics. Am J Trop Med Hyg 2008; 79:12-17    
Marcos LA, Tagle M, Terashima A, Bussalleu A, Ramirez C, Carrasco C, Valdez L, Huerta –Mercado J, Freedman DO, Vinetz JM, Gotuzzo E. Natural History, Clinico-Radiologic Correlates and Response to Triclabendazole in Acute Massive Fascioliasis Am J Trop Med Hyg 2008;78: 222-7   
Wilson CM and Freedman DO. Antiparasitic Agents. In: Long SS, Pickering LK, Prober CG. Principles and Practice of Pediatric Infectious Diseases. Third Edition. New York: Churchill Livingstone 2008; 1547-58.   
Freedman, DO. Filarial Infections. In: Goldman L, Ausiello D. Eds. Cecil Medicine, 23rd Edition. Philadelphia: Saunders Elsevier. 2008; 2432-37.    
Freedman DO, Weld LH, Kozarsky P, Fisk T, Robins R, Pandey P, von Sonnenburg F, Keystone J, and Cetron MS for the GeoSentinel Surveillance Network. Spectrum of Disease and Relation to Place of Exposure Among Ill Returned Travelers. N Engl J Med 2006; 254:119-30.    
Hill DR, Ericsson CD, Pearson RD, Keystone JS, Freedman DO, et al. The Practice of Travel Medicine: Guidelines by the Infectious Diseases Society of America, Clin Infect Dis 2006; 43:1499-1539.   
Freedman, DO. Onchocerciasis. IN: Guerrant RL, Walker DF, and Weller PF. Tropical Infectious Diseases: Principles, Pathogens, and Practice. 2nd Edition. Churchill-Livingstone Elsevier 2006 pp 1176-88.    
Modjarrad K, Zulu I, Redden DT, Njobvu L, Freedman DO, and Vermund SH. Prevalence and Predictors of Intestinal Helminth Infections Among HIV-1 Infected Adults in an Urban African Setting. Am J Trop Med Hyg 2005; 73: 777-82.    
Freedman DO and Leder K. Influenza: Changing Approaches to Prevention and Treatment in Travelers. J Travel Med 2005; 12:36-44.    
Cabada MM, Echeverria JI, Seas CR, Narvarte G, Samalvides F, Freedman DO, Gotuzzo E. Sexual Behavior of International Travelers Visiting Peru. Sex Transm Dis 2002;29: 510-13.   
Freedman DO, Gotuzzo E, Seas C, Legua P, Plier DA, Vermund SH, Casebeer LL. Educational Programs to Enhance Medical Expertise in Tropical Diseases: The Gorgas Course Experience 1996-2001. Am J Trop Med Hyg 2002;66: 526-32.   
Casebeer L, Freeman B, Kristofco RE, Grimes J, Gotuzzo E, and Freedman DO. Evaluation of the effectiveness of an international diploma course in tropical medicine. J Cont Educ Health Prof 2001; 21:97—102.   
Tang J, Freedman DO, Allen S, Karita E, Musonda R, Braga C, Margolick J, and Kaslow RA. TAP1 polymorphisms in several human ethnic groups: Characteristics, evolution, and genotyping strategies. Hum Immunol 2001; 62: 2560-68.   
Keystone JS, Kozarsky PE, Freedman DO. Internet and computer-based information sources for travel medicine practitioners. Clin Infect Dis 2001;32:757-65   
Freedman DO and Woodall J. Emerging infectious diseases and risk to the traveler. Med Clin NA 1999;83:865-83.   
Freedman DO, Plier DA, de Almeida AB, Braga C, Maia e Silva MC, Miranda J, Tang J, and Furtado A. Biased T-cell antigen receptor repertoire in infiltrating lesional T-cells in human bancroftian filariasis. J Immunol 1999;162:1756-64.   
Freedman, DO. Immune dynamics in the pathogenesis of human lymphatic filariasis. Parasitology Today. 1998;14:229-34.   
deAlmeida AB, Maia e Silva MC, Braga C, and Freedman DO. Differences in the frequency of cytokine producing cells in antigenemic and non-antigenemic indviduals with bancroftian filariasis. Infect Immun 1998;66:1377-83.   
Freedman DO, de Almeida A, Miranda J, Plier DA and Braga C. Field trial of a rapid card test for Wuchereria bancrofti. Lancet 1997;350:1681.   
Plier DA, Awadzi K, and Freedman DO. Immunoregulation in onchocerciasis: persons with ocular inflammatory disease produce a TH2 like response to Onchocerca volvulus antigen. J Infect Dis 1996;174:380-6.   
de Almeida A, Maia e Silva MC, Maciel MA, and Freedman DO. The presence or absence of active infection and not clinical status is most closely associated with cytokine responses in lymphatic filariasis. J Infect Dis 1996;173:1453-9.   
Freedman DO, Parker-Cook S, Maia e Silva C, Braga C, and Maciel A. The VLA-4/VCAM-1 pathway is involved in the trans-endothelial migration of lymphocytes in bancroftian filariasis. J Immunol 1996;156:2901-8.   
Freedman DO, Almeida PJ, Besh S, Silva MC, Braga C, Maciel MA, and Furtado AF. Abnormal lymphatic function in pre-symptomatic bancroftian filariasis. J Infect Dis 1995;171:997-1001.   
Freedman DO, Almeida PJ, Besh S, Silva MC, Braga C, and Maciel A. Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis. J Infect Dis 1994;170:927-33.   
Freedman DO, Lujan A, Steel C, Gonzales-Peralta C, and Nutman TB. Immunoregulation in onchocerciasis: functional and phenotypic abnormalities of lymphocyte subsets and changes with therapy. J Clin Invest 1991;88:231-8.   
Freedman DO, Nutman TB, and Ottesen EA. Protective immunity in bancroftian filariasis: selective recognition of a 43KD larval stage antigen by infection-free individuals in an endemic area. J Clin Invest 1989;83:14-22.