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Faculty Detail    
Name MICHELLE V FANUCCHI
 
Campus Address RPHB 534C Zip 0022
Phone 205-934-7230
E-mail fanucchi@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Environmental Health Sciences  Environmental Health Sciences Associate Professor
Secondary  Mechanical Engineering  Mechanical Engineering Associate Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor

Graduate Biomedical Sciences Affiliations
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Fanucchi was raised in Minnesota and received her Bachelor of Arts from the College of Saint Scholastica in Duluth, MN. She received her PhD in Pharmacology & Toxicology from the University of California at Davis. Her research mentor was Dr. Charles G. Plopper and her dissertation was titled "Naphthalene Cytotoxicity in Immature Clara Cells". Dr. Fanucchi then became a postdoctoral fellow in Environmental and Toxicologic Pathology with Dr. Jack R. Harkema at Michigan State University. She moved back to California to join the faculty of the School of Veterinary Medicine, University of California at Davis. In 2007, Dr. Fanucchi joined the Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham.

Society Memberships
Organization Name Position Held Org Link
American Thoracic Society  Professional Member  http://www.thoracic.org/ 
Society of Toxicology  Professional Member  http://www.toxicology.org/ 

Research/Clinical Interest
Title
Description
Childhood lung disease and its etiology. Pulmonary cell biology and toxicology of air polutants, including particulates, ozone, chlorine and various polyaromatic hydrocarbons. Cell-to-cell interactions in the developing lung as well as in repair after lung injury and disease in children.

Selected Publications 
Publication PUBMEDID
Fanucchi, MV, JA Hotchkiss, and JR Harkema. Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium. Toxicology and Applied Pharmacology 152:1-9, 1998  9772194  
Fanucchi, MV, AR Buckpitt, ME Murphy, and CG Plopper. Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice. Toxicology and Applied Pharmacology 144:96-104, 1998.  9308917  
Fanucchi, MV, ME Murphy, AR Buckpitt, RM Philpot, and CG Plopper. Pulmonary cytochrome P450 monooxygenase and Clara cell differentiation in mice. American Journal of Respiratory Cell and Molecular Biology 17:302-314, 1998.  9169074 
Einstein, D, B Neradilek, N Polissar, K Minard, C Wallis, M Fanucchi, J Carson, A Kuprat, S Kabilan, R Jacob, R Corley. An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat. Anat Rec (Hoboken) Dec; 291(12):1628-48, 2008   2741094 
Van Winkle, LS, JKW Chan, DS Anderson, B Kumfer, I Kennedy, M Kleeman, A Wexler, C Wallis, AD. Abid, KM Sutherland, and MV Fanucchi. Age specific responses to acute inhalation of diffusion flame soot particles: Cellular injury and the airway antioxidant response. Inhalation Toxicology, 2010. Oct 21 [epub ahead of print].   20961279  
Evans, MJ, MV Fanucchi, CG Plopper, and DM Hyde. 2010. The lamina reticularis in the developing primate airway. Anatomical Record 293:947-954.  20503389 
Carson JP, Einstein DR, Minard KR, Fanucchi MV, Wallis CD, Corley RA. High resolution lung airway cast segmentation with proper topology suitable for computational fluid dynamic simulations. Comput Med Imaging Graph. 2010 34(7):572-578.   20382502  
M Evans, M Fanucchi, L Miller, M Carlson, S Nishio, and D Hyde. Reduction of Collagen VII Anchoring Fibrils in the Airway Basement Membrane Zone of Infant Rhesus Monkeys Exposed to House Dust Mite. American Journal of Physiology - Lung Cellular and Molecular Physiology. 298(4):L543-547, 2010.  20139177  
Lee D, Fanucchi MV, Plopper CG, Fung J, Wexler AS. Pulmonary architecture in the conducting regions of six rats. Anat Rec (Hoboken) 291(8):916-26, 2008.  18561195  
Lee D, Wexler AS, Fanucchi MV, Plopper CG. Expiration rate drives human airway design. J Theor Biol. 253(2):381-7, 2008.  18430440  
Lee, D-Y,SS Park, GA Ban-Weiss, MV Fanucchi, CG Plopper, AS Wexler. Bifurcation model for characterization of pulmonary architecture. Anatomical Record (Hoboken): 291(4):379-89.  18228585  
Fanucchi, MV, CG Plopper, MJ Evans, DM Hyde, LS Van Winkle, LJ Gershwin, ES Schelegle. Cyclic Exposure to Ozone Alters Distal Airway Development in Infant Rhesus Monkeys. American Journal of Physiology: Lung Cellular Molecular Physiology, 291(4):L644-650, 2006.  16648242  
Kajekar, R, EM Pieczarka, SM Smiley-Jewell, ES Schelegle, MV Fanucchi, CG Plopper. Early Postnatal Exposure to Allergen and Ozone Leads to Hyperinnervation of the Pulmonary Epithelium. Respiratory Physiology & Neurobiology, 155(1):55-63, 2007.  16616710  
Day, KC, CG Plopper, MV Fanucchi. Age-specific pulmonary cytochrome P450 3A1 expression in postnatal and adult rats. American Journal of Physiology: Lung Cellular Molecular Physiology, 291(1): L75-83, 2006.  16461430  
Fanucchi, MV, KC Day, CC Clay and CG Plopper. Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury. Toxicology and Applied Pharmacology, 201:53-65, 2004.  15519608  
Tran, M-U, A Weir, M Fanucchi, A Rodriguez, L Van Winkle, M Evans, S Smiley-Jewell, L Miller, E Schelegle, L Gershwin, D Hyde, C Plopper. Smooth muscle development during postnatal growth of distal bronchioles in infant rhesus monkeys. Journal of Applied Physiology, 97:2364-2371, 2004.  15347627  
Fanucchi, MV, ES Schelegle, GL Baker, MJ Evans, RJ McDonald, LJ Gershwin, E Raz, DM Hyde, CG Plopper and LA Miller. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. American Journal of Respiratory and Critical Care Medicine, 170:1153-1157, 2004.  15306532  
Van Winkle, LS, MV Fanucchi, LA Miller, GL Baker, LJ Gershwin, ES Schelegle, DM Hyde, MJ Evans, CG Plopper. Epithelial cell distribution and abundance in rhesus monkey airways during postnatal growth and development. Journal of Applied Physiology, 97:2335-2363, 2004  15298983  
Evans, M, M Fanucchi, G Baker, L Van Winkle, L Pantle, S Nishio, E Schelegle, L Gershwin, L Miller, D Hyde and C Plopper. The remodeled tracheal basement membrane zone of infant rhesus monkeys after 6 months of recovery. Clinical and Experimental Allergy 34(7):1131-1136, 2004.  15248862  
Baker, GL, MA Shultz, MV Fanucchi, DM Morin, AR Buckpitt, and CG Plopper. Assessing gene expression in lung subcompartments utilizing in situ RNA preservation. Toxicological Sciences 77:135-141, 2004.  14600286  
Schelegle, ES, LA Miller, LJ Gershwin, MV Fanucchi, LS Van Winkle, JE Gerriets, WF Walby, V Mitchell, BK Tarkington, VJ Wong, GL Baker, LM Pantle, JP Joad, KE Pinkerton, R Wu, MJ Evans, DM Hyde and CG Plopper. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicology and Applied Pharmacology 191:74-85, 2003.  12915105  
Evans, MJ, MV Fanucchi, GL Baker, LS Van Winkle, LM Pantle, SJ Nishio, ES Schelegle, LJ Gershwin, LA Miller, DM Hyde, PL Sannes, and CG Plopper. Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen. American Journal of Physiology: Lung Cellular Molecular Physiology 285, L931-939, 2003.  12832283  
Evans, M. J., Fanucchi, M.V., Van Winkle, L. S., Baker, G. L., Murphy, A. E., Nishio, S. J., Sannes, P. L., and Plopper, C. G. Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone. American Journal of Physiology: Lung Cellular Molecular Physiology 283, L1263-1270, 2002.  12388330  
Schelegle, ES, LJ Gershwin, LA Miller, MV Fanucchi, LS Van Winkle, JP Gerriets, WF Walby, AM Omlor, AR Buckpitt, BK Tarkington, VJ Wong, JP Joad, KP Pinkerton, R Wu, MJ Evans, DM Hyde, and CG Plopper. Allergic asthma induced in Rhesus monkeys by house dust mite (Dermatophagoides farinae). American Journal of Pathology 158:333-341, 2001.  11141508  
Fanucchi, MV, AR Buckpitt, ME Murphy, DH Storms, BD Hammock, and CG Plopper. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicology and Applied Pharmacology 168:253-267, 2000.  11042098 
Plopper, CG and MV Fanucchi. Do urban environmental pollutants exacerbate childhood lung diseases? Environmental Health Perspectives 108:A252-A253, 2000.  10856036  
Fanucchi, MV, CG Plopper, JR Harkema, and JA Hotchkiss. In vitro culture of microdissected rat nasal airway tissue. American Journal of Respiratory Cell and Molecular Biology 20(6):1274-1285, 1999  10340947  
Lee, DY, C Wallis, A Wexler, E Schelegle, L Van Winkle, C Plopper, M Fanucchi, B Kumfer, I Kennedy, and J Chan. 2009. Small particles disrupt postnatal airway development. American Journal of Physiology - Lung Cellular and Molecular Physiology 2010. 109(4):1115-1124.  20634362 
Bartolucci, A, C Ballinger, S Bae, KP Singh, MV Fanucchi, and E Postlethwait. Examining the impact of Ozone on lung health in a vulnerable population: a Bayesian modeling strategy. 18th World IMACS / MODSIM Congress, Cairns, Australia 13-17 July 2009.