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Faculty Detail    
Campus Address KAUL 752A
Phone 205-996-7083
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Assistant Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Assistant Professor
Center  Heflin Genetics Center  Heflin Genetics Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Genetics and Genomic Sciences 

Biographical Sketch 
Chiquito Crasto graduated from the Indian Institute of Technology, Mumbai with a degree in Chemistry. After obtaining a Master's Degree in Chemistry from The Ohio State University, Dr. Crasto completed his doctorate in Chemistry from the University of New Orleans.

Dr. Crasto worked as a postdoctoral fellow at the Fox Chase Cancer Center in Philadelpha conducting research in bioinformatics and macromolecular crystallographywhere. Here, he won the Plain and Fancy Postdoctoral Fellowship .

Dr. Crasto then moved to a second postdoctoral stint at the Yale University School of Medicine, Departments of Neurobiology and Center for Medical Informatics. He was soon promoted to Associate Research Scientist. His research experience include protein modeling, simulations of interactions with proteins and small molecule. Dr. Crasto is also working on database development and the application of mathematical methodologies to knowledge management.

Dr. Crasto also worked as an Adjunct faculty at the University of New Haven in Connecticut, teaching Chemistry and Proteomics.

Dr. Crasto has been appointed as Assistant Professor at the Helfin Center for Human Genetics since May 2007. Since 2009, Dr. Crasto has held secondary appointments in the Programs in Interdisciplinary Engineering and Biochemistry and Structural Biology.

Research/Clinical Interest
Assistant Professor
Developing bioinformatics tools for the analysis and presentation of data arising from microarray-based experiments. Using computational biology techniques to elucidate the interactions between olfactory receptors and odor molecules; also carrying out genomic and proteomic studies of olfactory receptors to trace the evolution of olfaction in vertebrates and invertebrates. Dr. Crasto is currently the Scientific Coordinator of the Olfactory Receptor Database housed at the Yale University School of Medicine. Developing of mathematical techniques to manage the knowledge associated with bio-medical data. Dr. Crasto has developed information-extraction based text and data-mining solutions. He is interested in creating information management tools with a focus on neurological disorders.

Selected Publications 
Publication PUBMEDID
Feng JA, Crasto CJ, Matsumoto Y.
Deoxyribose phosphate excision by the N-terminal domain of the polymerase beta: the mechanism revisited.
Biochemistry. 1998 Jul 7;37(27):9605-11. 
Crasto C, Luo D, Yu F, Forero A, Chen D. GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer.
BMC Med Inform Decis Mak. 2011 May 5;11:28. 
Popławski AB, Jankowski M, Erickson SW, Díaz de Ståhl T, Partridge EC, Crasto C, Guo J, Gibson J, Menzel U, Bruder CE, Kaczmarczyk A, Benetkiewicz M, Andersson R, Sandgren J, Zegarska B, Bała D, Srutek E, Allison DB, Piotrowski A, Zegarski W, Dumanski JP.
Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. Eur J Hum Genet. 2010 May;18(5):560-8. Epub 2010 Jan 6. 
Yang Y, Hruby VJ, Chen M, Crasto C, Cai M, Harmon CM. Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry. 2009 Oct 20;48(41):9775-84.   19743876 
Peter C. Lai, Gautam Bahl, Maryse Gremigni, Valery Matarazzo, Olivier Clot-Faybesse, Catherine Ronin and Chiquito J. Crasto.
An olfactory receptor pseudogene whose function emerged in humans: a case study in the evolution of structure–function in GPCRs. ournal of Structural and Functional Genomics. 9(1), 29-40, (2008). 
Piotrowski A, Bruder CE, Andersson R, Diaz de Ståhl T, Menzel U, Sandgren J, Poplawski A, von Tell D, Crasto C, Bogdan A, Bartoszewski R, Bebok Z, Krzyzanowski M, Jankowski Z, Partridge EC, Komorowski J, Dumanski JP.
Somatic mosaicism for copy number variation in differentiated human tissues. Hum Mutat. 2008 Sep;29(9):1118-24. 
Carl E.G. Bruder, Arkadiusz Piotrowski, Antoinet A.C.J. Gijsbers, Robin Andersson, Stephen Erickson, Teresita Diaz de St&umlahl, Uwe Menzel, Johanna Sandgren, Desiree von Tell, Andrzej Poplawski, Michael Crowley, Chiquito J. Crasto, E. Christopher Partridge, Hemant Tiwari, David B. Allison, Jan Komorowski, Gert-Jan B. van Ommen, Dorret I. Boomsma, Nancy L. Pedersen, Johan T. den Dunnen, Karin Wirdefeldt, and Jan P. Dumanski.
Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation Profiles.
Am J Hum Genet. 2008 Mar;82(3):763-71. Epub 2008 Feb 14. 
Man O, Willhite DC, Crasto CJ, Shepherd GM, Gilad Y.
A framework for exploring functional variability in olfactory receptor genes. PLoS ONE. 2007 Aug 1;2:e682. 
Liu N, Crasto CJ, Ma M.
Integrated olfactory receptor and microarray gene expression databases. BMC Bioinformatics. 2007 Jun 30;8:231. 
Crasto CJ, Marenco LN, Liu N, Morse TM, Cheung KH, Lai PC, Bahl G, Masiar P, Lam HY, Lim E, Chen H, Nadkarni P, Migliore M, Miller PL, Shepherd GM.
SenseLab: new developments in disseminating neuroscience information. Brief Bioinform. 2007 May;8(3):150-62. 
Crasto CJ, Masiar P, Miller PL.
NeuroExtract: facilitating neuroscience-oriented retrieval from broadly-focused bioscience databases using text-based query mediation. J Am Med Inform Assoc. 2007 May-Jun;14(3):355-60. 
Lai PC, Singer MS, Crasto CJ.
Structural activation pathways from dynamic olfactory receptor-odorant interactions. Chem Senses. 2005 Nov;30(9):781-92. 
Crasto CJ, Morse TM, Migliore M, Nadkarni P, Hines M, Brash DE, Miller PL, Shepherd GM.
Text mining neuroscience journal articles to populate neuroscience databases. Neuroinformatics. 2003;1(3):215-37. 
Marenco L, Tosches N, Crasto C, Shepherd G, Miller PL, Nadkarni PM.
Achieving evolvable Web-database bioscience a pplications using the EAV/CR framework: recent advances. J Am Med Inform Assoc. 2003 Sep-Oct;10(5):444-53. 
Crasto C, Marenco L, Miller P, Shepherd G.
Olfactory Receptor Database: a metadata-driven automated population from sources of gene and protein sequences. Nucleic Acids Res. 2002 Jan 1;30(1):354-60. 
Crasto CJ, Feng J.
Sequence codes for extended conformation: a neighbor-dependent sequence analysis of loops in proteins. Proteins. 2001 Feb 15;42(3):399-413. 
Crasto CJ, Feng JA.
LINKER: a program to generate linker sequences for fusion proteins. Protein Eng. 2000 May;13(5):309-12. 
Crasto C. Hydrophobicity profiles in G protein-coupled receptor transmembrane helical domains. Journal of Receptor, Ligand and Channel Research. 2010. 3:123-133.   
Chiquito J. Crasto. Computational Biology of Olfactory Receptors. Current Bioinformatics. 4(1), 1-7, (2009).   
Chiquito J. Crasto and Edwin D. Stevens.
Use of electrostatic potentials to study non-bonded, intramolecular, interactions in 1,8-disubstituted naphthalenes with azo-group as the electrophilic substituents. Journal of Molecular Structure (THEOCHEM), 582, (2002), 77-84. 
Chiquito J. Crasto and Edwin D. Stevens.
Use of Electrostatic potentials to study non-bonded intramolecular interactions in 1,8 di-substituted naphthalenes with carbonyl groups as electrophilic substituents. Journal of Molecular Structure (THEOCHEM), 454, (1998), 51-59. 

olfactory receptors, protein modeling, simulation, knowledge management, database development, neurological disorders