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Faculty Detail    
Name YABING CHEN
Professor, Molecular and Cellular Pathology
 
Campus Address SHEL 614 Zip 2182
Phone 205-996-6293
E-mail ybchen@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Associate Professor
Center  Center for Aging  COMPREHENSIVE CTR FOR HEALTHY AGING Associate Professor
Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor
Center  Medicine  Comprehensive Diabetes Ctr Associate Professor
Center  Medicine  Ctr Cardiovasc Bio Associate Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Associate Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Associate Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Chen received her BS degree from Fudan University and her Ph.D. from Xiamen University. She completed postdoctoral training and was appointed as a research instructor at the University of Vermont, School of Medicine. Dr. Chen joined the faculty of Department of Pathology at UAB in June 2004. She is currently Professor in Molecular and Cellular Pathology as well as Principal Investigator at the Birmingham VA Medical Research Division. Dr. Chen serves as an editorial board member for Circulation Research (Circ Res), Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) and the Journal of Biological Chemistry (JBC). She is a Fellow of the American Heart Association (AHA) and vice-chair of the ATVB Committee on Scientific Sessions Program (CSSP) of the AHA. Dr. Chen has served the National Institutes of Health (NIH) Atherosclerosis and Inflammation of the Cardiovascular System (AICS) and Vascular Cell and Molecular Biology (VCMB) study sections as an Ad Hoc reviewer in the past few years, and she is currently a regular member of the VCMB study section.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research  Member   
American Heart Association  Fellow   
American Society for Bone and Mineral Research  Member   

Research/Clinical Interest
Title
Gene Regulation and Function in the Pathogenesis of Disease
Description
Regulation of vascular smooth muscle cells (VSMC) contributes significantly to the development of cardiovascular diseases, including atherosclerosis and hypertension. Vascular calcification is a feature of advanced atherosclerosis, a process of differentiation of VSMC to “bone-like” cells that resembles the process of osteogenesis. Increased oxidative stress accelerates the progression of atherosclerosis and vascular calcification. Projects involve characterization of molecular signals that regulates osteogenic transcription factor Runx2 in vascular calcification, as well as mechanisms underlying Runx2 in modulating the pathogenesis of atherosclerosis and vascular calcification. We have also discovered that calcifying vascular smooth muscle cells produce RANKL, which promotes macrophage infiltration and formation of vascualr osteoclasts in close apposition of calcified atherosclerotic lesions. We use cell culture systems and conditional knock out mouse models to elucidate the molecualr mechanisms of vascular calcification and vascualr osteoclastogenesis, which may lead to novel strategies and targets to treat atherosclerosis. In cancer biology, we have been investigating the molecular mechanisms that regulate death receptor signaling pathways in tumorigenesis and resistence. Currently, we are elucidating molecular mechanisms of resistance of pancreatic cancer to therapy with anti-death receptor 5 antibody. These studies will define novel mediators in the apoptotic machinery, and may lead to identification of new compounds that overcome drug resistance.

Positions Available
Date Posted Position Title
9/2/2014  Postdoctoral Associate/Fellow 
We are currently seeking postdoctoral associates to study molecular mechanisms of gene regulation in the development of cardiovascular disease and cancer. A strong background in molecular and cellular biology is essential. Experience with primary cell culture and mouse model analysis is desirable. Recent PhDs in biomedical science are encouraged to apply. Preference will be given to self-motivated and career-oriented candidates. Please send your CV and a summary of your research interests to Yabing Chen at ybchen@uab.edu.    

Selected Publications 
Publication PUBMEDID
Heath J, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'italia LJ, Chatham JC, Wu H, Chen Y.
Activation of AKT by O-GlcNAcylation Induces Vascular Calcification in Diabetes.
Circ Res. 2014 Mar 28;114(7):1094-102
-- An Editor's pick
-- Published with an accompanying editorial
-- A most often read paper in Circ Res journal in Aug 2014 
24526702 
Yuan K, Sun Y, Zhou T, McDonald JM, Chen Y.
PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy
Clin Cancer Res. 2013, 19(17):4750-9. 
23833311 
Sun Y, Byon CH, Yuan K, Chen J, Mao X, Heath JM, Javed A, Zhang K, Anderson PG, Chen Y.
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.
Circ Res. 2012 Aug 17;111(5):543-52. Epub 2012 Jul 6.
-- A top downloaded article in Circ Res journal in July 2012
-- Highlighted in the Circ Res Thematic Synosis on Atherosclerosis. 
22773442 
Mao X, Debenedittis P, Sun Y, Chen J, Yuan K, Jiao K, Chen Y.
Vascular smooth muscle cell smad4 gene is important for mouse vascular development.
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2171-7. Epub 2012 Jul 5. 
22772757 
Chen J, Yuan K, Mao X, Miano JM, Wu H, Chen Y.
Serum response factor regulates bone formation via IGF-1 and Runx2 signals.
J Bone Miner Res. 2012 Aug;27(8):1659-68. Epub 2012 Mar 20  
22434656 
Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y.
Runx2-Upregulated Receptor Activator of Nuclear Factor {kappa}B Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages.
Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1387-96. Epub 2011 Mar 31
-- Published with an accompanying editoral. 
21454810  
Chen J, Sun Y, Mao X, Liu Q, Wu H, Chen Y.
RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.
J Biol Chem. 2010 Nov 19;285(47):36315-21. Epub 2010 Sep 13.  
20837480  
Pawar P, Ma L, Byon CH, Liu H, Ahn EY, Jhala N, Arnoletti JP, McDonald JM, Chen Y.
Molecular Mechanisms of Tamoxifen Therapy for Cholangiocarcinoma: Role of Calmodulin.
Clin Cancer Res. 2009;15(4):1288-1296. 
19228732 
Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H, Wang D
Phospholipase Cgamma 2 mediates RANKL-stimulated lymph-node organogenesis and osteoclastogenesis.
J Biol Chem. 2008; 283(43):29593-601. 
18728019 
Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y.
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx-2 by Akt signaling.
J Biol Chem. 2008;283(22):15319-27
-- A featured Article in vascualr biology, selected by NAVBO in 2008 
18378684  
Chen Y*, Budd RC, Kelm RJ Jr, Sobel BE, Schneider DJ.
Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1.
Arterioscler Thromb Vasc Biol. 2006, 26(8):1777-83 
16709941 
Chen Y, Billadello JJ, Schneider DJ.
Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene.
Arterioscler Thromb Vasc Biol. 2000, 20(12):2696-701. 
11116074  

Keywords
vascular calcification, vascular osteoclasts, tumorigenesis and resistance