Back to Main

Faculty Detail    
Name DAVID D CHAPLIN
 
Campus Address SHEL 514 Zip 2182
Phone 205-934-3917
E-mail dchaplin@uab.edu
Other websites PubMed Listing
     

Education
Undergraduate  Harvard College    1973  A.B. 
Medical School  Washington University School of Medicine    1980  M.D. 
Graduate  Washington University School of Medicine    1980  Ph.D. 
Residency  Univ. of Texas, Southwestern Medical School    1982  M.D. 
Fellowship  Harvard University    1984  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Microbiology  Microbiology Professor
Secondary  Medicine  Med - Pulmonary/Allergy/Critical Care Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Hughes Med-Grad Fellowship Program 
Immunology 

Biographical Sketch 
Dr. Chaplin completed his undergraduate education at Harvard University in 1973, then undertook graduate training in the MD/PhD program at Washington University, graduating in 1980. He completed two years of Internal Medicine Residency at U of Texas/Southwestern Medical School, Parkland Memorial Hospital. His post-doctoral research training was with Dr. J.G. Seidman in the Department of Genetics at Harvard Medical School, studying the genetics of the murine major histocompatibility complex. In 1984, he accepted a position as Associate Investigator of the Howard Hughes Medical Institute and Assistant Professor of Medicine, Molecular Microbiology, and Genetics at Washington University in St. Louis. He was promoted to Associate Professor in 1992, and Professor in 1995. He was Director of the Division of Allergy and Immunology from 1994-2001. In July 2001, he joined the faculty of UAB as Charles H. McCauley Professor and Chairman of the Department of Microbiology.

Society Memberships
Organization Name Position Held Org Link
American Academy of Allergy Asthma and Immunology     
American Association for the Advancement of Science     
American Society for Microbiology     
Association of American Physicians     
Association of Medical School Microbiology & Immunology Chairs     
Clinical Immunology Society     
Southeastern Branch American Society for Microbiology     
The American Association of Immunologists     
The American Society for Clinical Investigation     

Research/Clinical Interest
Title
Interplay between innate and adaptive immunity in asthmatic inflammation
Description
Dr. Chaplinís laboratory aims to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifest in tissues through the action of the adaptive immune response. He has a special interest in the ways commensal and pathogenic microbes that are present in the lung alter allergic inflammatory responses such as those that underlie asthmatic inflammation. He is testing the hypothesis that airway microbes impact the quality and quantity of asthmatic inflammation largely through their induction of myeloid-derived regulatory cells (MDRC). Lung and airway MDRC, defined by Dr. Chaplinís laboratory in 2011, constitute several discrete populations of cells that determine the overall inflammatory tone in the tissues through their production of cytokines, chemokines, and reactive nitrogen and oxygen free radical species. Dr. Chaplinís laboratory demonstrated in studies using a mouse model that superoxide-producing MDRC dramatically accentuate airway hyperresponsiveness after exposure to aerosolized antigen. In contrast, populations of nitric oxide-producing MDRC blunt airway hyperresponsiveness, suggesting that the nitric oxide/superoxide axis may be a valuable target for future development of novel anti-asthmatic therapeutics.

Selected Publications 
Publication PUBMEDID
Nabe T., Ikedo A., Hosokawa F., Kishima M., Fujii M., Mizutani N., Yoshino S., Ishihara K., Akiba S., Chaplin D.D. (2012): Regualatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma. Eur. J. Pharmacol 677:154-62.  22209878 
Deshane J., Zmijewski J.W., Luther R., Gaggar A., Deshane R., Lai J.F., Xu X., Spell M., Estell K., Weaver C.T., Abraham E., Schwiebert L.M., Chaplin D.D. (2011). Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Mucosal Immunol 4:503-18.  21471960 
Deshane J., Chaplin D.D. (2010): Folicular Dendritic Cell Makes Environmental Sense. Immunity 33:2-4.  20643332 
Zindl C.L., Chaplin D.D. (2010): Immunology. Tumor immune evasion. Science 328:697-698.   20448171 
Jung Y.W., Zindl C.L., Lai J.-F., Weaver C.T., Chaplin D.D. (2009): Matrix metalloproteinases induced by Gr-1+ cells are crucial for recruitment of Th cells into airways. Eur J Immunol 39:2281-2292.   19593770 
Zindl C.L., Kim T.H., Zeng M., Archambault A.S., Grayson M.H., Choi K., Schreiber R.D., Chaplin D.D. (2009): LTalpha1beta2 controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity 30:408-420.   19303389 
Le T.L., Chaplin D.D. (2008): Intra-clonal competition inhibits the formation of high affinity antibody secreting cells. J Immunol 181:6027-6037.  18941192 
Matsumoto M., Zhou Y., Matsuo S., Nakanishi H., Hirose K., Oura H., Arase S., Ishida-Yamamoto A., Bando Y., Izumi K., Kiyonari H., Oshima N., Nakayama R., Matsushima A., Hirota F., Mouri Y., Kuroda N., Sano S., Chaplin D.D. (2008): Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc Natl Acad Sci USA 105:6720-6724.  18436651 
Jung Y.W., Schoeb T.R., Weaver C.T., Chaplin D.D. (2006): Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168:1425-1434.   16651610 
Chaplin D.D., Zindl C.L. (2006): Taking control of follicular dendritic cells. Immunity 24:13-15.  16413918 
Stephens R., Randolph D.A., Huang G., Holtzman M.J., Chaplin D.D. (2002): Antigen-non-specific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma. J Immunol 169:5458-5467.  12421921 
Randolph D.A., Huang G., Carruthers C.J.L., Bromley L.E., Chaplin D.D. (1999): The Role of CCR7 in T(H)1 and T(H)2 Cell Localization and Delivery of B Cell Help in Vivo. Science 286:2159-2162.  10591648 

Keywords
Inflammation, Lymphoid tissues, Innate immunity, T cells, Macrophages, Microbiome