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Faculty Detail    
Name MARY BALLESTAS
Ph. D.
 
Campus Address CHB 148 Zip 0011
Phone 205-996-6082
E-mail marybb@uab.edu
Other websites http://www.uab.edu/medicine/neurosciencecore/
     

Education
Undergraduate  Tulane University    1982  B. S.  
Graduate  University of Southern Maine    1991  M. S.  
Graduate  University of Alabama at Birmingham    1997  Ph. D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pediatrics   Ped - Infectious Disease Assistant Professor
Center  Center for AIDS Research  Center for AIDS Research Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Biographical Sketch 
1997-2000 Postdoctoral Fellow, Harvard Medical School and Brigham and Women's Hospital Infectious Disease Division
2001-2003 Instructor in Medicine, Harvard Medical School and Brigham and Women's Hospital Infectious Disease Division
2004-2005 Instructor, Tulane Medical School, Department of Biochemistry and Human Genetics
2006 Assistant Professor, University of Alabama at Birmingham School of Medicine, Division of Pediatrics-ID
2009 Scientist, UAB Center for AIDS Research
2009 Associate Scientist, UAB Comprehensive Cancer Center
2009 Associate Scientist, UAB Comprehensive Neuroscience Center

Society Memberships
Organization Name Position Held Org Link
AAAS     
ASM     

Research/Clinical Interest
Title
Description
My research interests are the oncogenic herpesviruses, KSHV and EBV (human herpesviruses 8 and 4 respectively). Mechanisms of viral latency, host-viral interactions, and pathology of Kaposiís sarcoma are studied with the focus to develop novel and rationally designed therapeutic targets for these cancer causing viruses.

Selected Publications 
Publication PUBMEDID
D. Jones, M. E. Ballestas, K. M. Kaye, J. M. Gulizia, G. L. Winters, J. Fletcher, D. T. Scadden, and J.
C. Aster. Primary-Effusion Lymphoma and Kaposi’s Sarcoma in a Cardiac Transplant Recipient. New
England Journal of Medicine, 1998; 339:444-449.  
9700178 
M. E. Ballestas and K. M. Kaye. The Latency-Associated Nuclear Antigen, a Multifunctional Protein Central to Kaposi’s Sarcoma-Associated Herpesvirus Latency, Future Microbiology, 2011; 6 (12) 1399-1413.   22122438 
Sabarish V. Indran, Mary E. Ballestas, and William J. Britt. Bicaudal D1-Dependent Trafficking of
Human Cytomegalovirus Tegument Protein pp150 in Virus Infected Cells. J Virol, 2010; 84 (7): 3162-
77.  
20089649 
B. Kelley-Clarke, M. E. Ballestas, V. Srinivasan, A. J. Barbera, T. Komatsu, T.-A. Harris, M.
Kazanjian, and K.M. Kaye. Determination of Kaposi’s sarcoma-associated herpesvirus C-terminal
latency-associated nuclear antigen residues mediating chromosome association and DNA binding. J
Virology, 2007; 81 (8) 4348-56.  
17287261 
B. Kelley-Clarke*, M. E. Ballestas*, T. Komatsu, and K. M. Kaye. Kaposi’s sarcoma herpesvirus C-
terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic
chromosomes. Virology, 2007; 357(2) 149-157, (*contributed equally). PMID: . 
16979209 
J. You, V. Srinivasan, G. Denis, W.J. Harrington Jr, M.E. Ballestas, K.M. Kaye, and P.M. Howley. The
Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with
Bromodomain Protein Brd4 on Host Mitotic Chromosomes, J Virology, 2006; 80(18):8909-19.  
16940503 
V. Srinivasan, T. Komatsu, M. E. Ballestas, and K. M. Kaye. Definition of sequence requirements for
latency-associated nuclear antigen 1 binding to Kaposi’s sarcoma-associated herpesvirus DNA, J
Virology, 2004; 78(24):14033-8.  
15564510 
T. Komatsu, M. E. Ballestas, A. J. Barbera and K. M. Kaye. KSHV LANA1 binds DNA as an oligomer
and residues N-terminal to the oligomerization domain are essential for DNA binding, replication and episome persistence, Virology, 2004; 319(2):225-36.  
14980483 
A. J. Barbera, M. E. Ballestas, and K. M. Kaye. The Kaposi’s Sarcoma-Associated Herpesvirus
Latency-Associated Nuclear Antigen 1 N-terminus is Critical for Chromosome Association, DNA
Replication, and Episome Persistence, J Virology, 2004; 78(1):294-301. 
14671111 
M. E. Ballestas and K. M. Kaye. The Latency Associated Nuclear Antigen Mediates Episome
Persistence Through Cis-acting Terminal Repeat Sequence, J Virol, 2000; 75: 3250-3258  
11238851 
M. E. Ballestas, P. A. Chatis, K. M. Kaye. Efficient Persistence of Extrachromosomal KSHV DNA
Mediated by Latency-Associated Nuclear Antigen. Science, 1999; 284:641-644  
10213686 
V. Alexiadis, M. E. Ballestas, C. Sanchez, S. Winokur, V. Vedanarayanan, M. Warren, and M. Ehrlich.
RNA Ploymerase Chromatin Immunoprecipitation Analysis of Transcription from Muscular Dystrophy-
Linked Tandem Repeats and Satellite DNA, Biochimica and Biophsica Acta-Gene Structure and
Expression, 2007; 1769: 29-40.  
17239456 

Keywords
Herpesvirus, Cancer