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Faculty Detail     Name TALENE ALENE YACOUBIAN   Campus Address CIRC 560D Zip 0021 Phone 205-996-7543 E-mail tyacoub@uab.edu Other websites http://medicine.uab.edu/neurology/DivsPgmsCtrs/CNET/labs/yacoubian/

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurology   Neurology Chair Office Assistant Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  Neurology   Alzheimer's Disease Center Assistant Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Medical Scientist Training Program  Neuroscience  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Talene Yacoubian, MD, PhD, joined the Department of Neurology in July of 2006, and is currently an Assistant Professor. Dr. Yacoubian received her undergraduate degree from Harvard University, and her MD/PhD from Duke University in 2001. She completed a one year internship at Brigham & Women's Hospital, Boston and a 3 year Residency in Neurology at Massachusetts General Hospital/Brigham & Women's Hospital. She finished a two year Fellowship in Movement Disorders in July of 2008. Dr. Yacoubian is a recipient of the American Parkinson Disease Association’s George C. Cotzias, MD Memorial Fellowship and a NINDS K08 Mentored Clinical Scientist Development Award. She is an Assistant Professor in the Center for Neurodegeneration and Experimental Therapeutics and the Parkinson's Association of Alabama Scholar. She currently divides her time between patient care and laboratory research focused on Parkinson’s disease.

Society Memberships Organization Name Position Held Org Link Alpha Omega Alpha Medical Society  Member    American Academy of Neurology  Member    Movement Disorders Society  Member    Society for Neuroscience  Member

Research/Clinical Interest Title Role of 14-3-3 proteins in Parkinson’s disease Description The Yacoubian Lab is focused on understanding the pathophysiology of Parkinson's disease with the long-term goal of developing neuroprotective therapies. The main focus of the lab is the family of 14-3-3 proteins and their role in Parkinson's disease. We have demonstrated disruption of 14-3-3 expression and function in Parkinson's disease models. Since these proteins play a key role in cell survival through the inhibition of pro-apoptotic factors, we are investigating whether increasing 14-3-3 levels can mitigate toxicity in both in vitro and in vivo models of Parkinson's disease. We employ a variety of cellular and molecular techniques. A second focus of the lab is the protein angiogenin and its potential neuroprotective role in Parkinson's disease.

Selected Publications  Publication PUBMEDID Lee YJ, Wang S, Slone SR, Yacoubian TA, Witt SN. Defects in Very Long Chain Fatty Acid Synthesis Affect Alpha-Synuclein Trafficking and Aging in a Yeast Model of Parkinson's Disease, PLoS One, 2011;6(1):e15946.   21264320  Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG. Differential neuroprotective effects of 14-3-3 proteins in PD models. Cell Death Dis 1: e2; doi:10.1038/cddis.2009.4  21152247   Steidinger T, Standaert DG, Yacoubian TA. A neuroprotective role for angiogenin in models of Parkinson’s Disease, J Neurochem 2011;116(3):334-41.  21091473  Standaert DG, Yacoubian T. Target Validation: the Parkinson Disease Perspective. Dis Model Mech. 2010; 3(5-6):259-62.  20427553  Yacoubian TA, Howard G, Kissela B, Sands CD, Standaert DG. Racial Differences in Parkinson's Disease Medication Use in the Reasons for Geographic and Racial Differences in Stroke Cohort: A Cross-Sectional Study. Neuroepidemiology. 2009;33(4):329-334. Epub 2009 Nov 4.  19887838  Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian T, Wilson S, Xie Z-L, Speake L, Parks R, Crabtree D, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu Y, Standaert D, Walls KC, Shacka JJ, Roth KA, Zhang J. Lysosomal enzyme cathepsin D protects against neuronal alpha-synuclein aggregation and toxicity. Molecular Brain. 2008;1(1):17.   19021916  Yacoubian TA, Standaert DG. Targets for neuroprotection in Parkinson’s disease. Biochim Biophys Acta. 2009 Jul;1792(7):676-87. Epub 2008 Oct 1.  18930814  Yacoubian TA, Cantuti-Castelvetri I, Bouzou B, Asteris A, McLean PJ, Hyman BT, Standaert DG. Transcriptional dysregulation in a transgenic model of Parkinson’s disease. Neurobiol Dis. 2008 Mar;29 (3): 515-28.   18191405  Yacoubian TA, Lo DC. Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nature Neurosci. 2000; 3:342-349.   10925923  Kryl D, Yacoubian T, Haapasalo A, Castren E, Lo D, Barker PA. Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. J Neurosci. 1999; 19:5823-5833   10407023  First Prev   1 2 of  2  Next Last

Keywords Parkinsons disease; Neurobiology; Molecular Genetics & Disease

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