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Faculty Detail     Name QIN WANG   Campus Address MCLM 986 Zip 0005 Phone 205-996-5099 E-mail qinwang@uab.edu Other websites

Education Medical School  Beijing Medical University    1992  MD  Graduate  University of Iowa    1999  PhD

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  Medicine  Comprehensive Diabetes Ctr Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Integrative Biomedical Sciences  Neuroscience  Neuroscience Graduate Program  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Qin Wang received her M.D. degree from Beijing Medical University, China. After traveling to the US, she obtained her Ph.D. degree in December 1999 from University of Iowa. She then did her postdoc work at Vanderbilt University, where she was appointed as a Research Assistant Professor two years later. In June 2005, Dr. Wang joined the Department of Physiology and Biophysics as an Assistant Professor.

Society Memberships Organization Name Position Held Org Link American Heart Association      American Physiology Society      American Society for Pharmacology and Experimental Therapeutics

Research/Clinical Interest Title Regulation of GPCR trafficking, signaling and in vivo functions Description The long term goal of our research is to reveal novel regulatory pathways controlling G protein-coupled receptors (GPCRs) functions at the molecular and cellular levels and to understand how these regulatory mechanisms influence GPCR-elicited physiological functions in vivo, so as to provide new insights for therapeutic strategies. Current projects include: 1) regulation of alpha2A adrenergic receptor trafficking and signaling in native neurons exploiting gene knock-in and knock-out mice; 2) regulation of adenosine-mediated synaptic plasticity and behavior; 3) functions of the alpha2A adrenergic receptor in neurodegenerative diseases.

Selected Publications  Publication PUBMEDID Cottingham C and Wang Q (2012). Alpha2 adrenergic receptor dysregulation in depressive disorders: implications for depressive neurobiology and antidepressant therapy. Neurosci Biobehav Rev. 36, 2214-2225.    Cottingham C, Jones A and Wang Q (2012) Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Biochem Biophys Res Commun. 420, 161-165.    Cottingham C, Li X and Wang Q (2012) Noradrenergic antidepressant responses in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology 62, 2353-2361.    Chen Y, Liu Y, Cottingham C, McMahon L, Jiao K, Greengard P and Wang Q (2012) Neurabin scaffolding of the adenosine receptor and RGS4 regulates anti-seizure effect of adenosine. J Neurosci., 32, 2683-2695. (Commentary on Purinergic signal. 2012, 8:659; Highlighted on Nature SciBX: Science-Business eXchange, and on Global Medical Discovery).    Cottingham C, Chen H, Chen Y, Peng Y and Wang Q (2011). Genetic variations of alpha2 adrenergic receptors illuminate the diversity of receptor functions. Curr Top Membr. 67, 161-190.    Cottingham C, Chen Y, Jiao K and Wang Q (2011) Desipramine is an arrestin-biased ligand at the alpha 2A adrenergic receptor driving receptor downregulation in vitro and in vivo. J Biol Chem., 286, 36063-36075. (Highlighted in Faculty of 1000).    DeBenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K (2011) Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem Biophys Res Commun. 409, 338-343.    Nie X, Brown B, Wang Q and Jiao K (2010) Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs. 193, 393-403.     Lu R, Chen Y, Peng N, Jiao K, Limbird LE, Wyss JM and Wang Q (2010) Hypnotic and hypotensive responses to alpha2-adrengergic agent are potentiated and accompanied by enhanced G protein coupling to the receptor in spinophilin null mice. Mol. Pharm. 78, 279-286.    Shields AD, Wang Q, Winder DG (2009) Alpha2A-Adrenergic Receptors Heterosynaptically Regulate Glutamatergic and GABAergic transmission in the BNST. Neuroscience, 163, 339-351.     First Prev   1 2 3 of  3  Next Last

Keywords GPCR, trafficking, ligand-selective, interacting proteins, adenosine, adrenergic, neuroprotection

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