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Faculty Detail     Name LINDA S. WADICHE   Campus Address SHEL 1003 Zip 2182 Phone 205-996-6414 E-mail lwadiche@uab.edu Other websites http://www.neurobiology.uab.edu/Faculty/Wadiche_L/Lwadiche.htm

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurobiology  Neurobiology Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Center  Center for Aging  Center for Aging Associate Professor Center  Civitan International Research Center  Civitan International Research Center Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program

Biographical Sketch  Linda Overstreet Wadiche received a BS in Biology from North Park University in Chicago, IL. In 1997 she received her Ph.D. from the Department of Physiology at Northwestern University Medical School under the mentorship of Dr. N. Traverse Slater. From 1998-2004 she was a postdoctoral fellow with Dr. Gary Westbrook at the Vollum Institute, Oregon Health & Science University. Dr. Wadiche became a Research Assistant Professor at the Vollum Institute in 2004. In June of 2006 she joined the Department of Neurobiology at UAB as an Assistant Professor.

Research/Clinical Interest Title The function of adult generated neurons Description Most neurons in the brain are generated during embryogenesis. However, neural stem cells in discrete regions of the adult continuously produce newborn neurons that can functionally integrate by forming synapses with the existing neural circuitry. One of the regions where adult neurogenesis occurs is the dentate gyrus, an area that is involved learning and memory. My laboratory focuses on the mechanisms underlying functional maturation and synaptogenesis of newborn granule cells, the principal neurons in the dentate gyrus. We use a variety of techniques to explore how newborn neurons survive and integrate, and how these processes are modified by aging, exercise and disease.

Selected Publications  Publication PUBMEDID Desynchronization of multivesicular release enhances Purkinje cell output. Rudolph S, Overstreet-Wadiche L, Wadiche JI. Neuron. 2011 Jun 9;70(5):991-1004.  21658590  Enhanced integration of newborn neurons after neonatal insults. Pugh P, Adlaf E, Zhao CS, Markwardt S, Gavin C, Wadiche J, Overstreet-Wadiche L. Front Neurosci. 2011 Mar 30;5:45.  21490706  Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. Cell Stem Cell. 2010 Oct 8;7(4):483-95.  20887954  Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus. Markwardt SJ, Wadiche JI, Overstreet-Wadiche LS. J Neurosci. 2009 Dec 2;29(48):15063-72.  19955357  Ivy/Neurogliaform interneurons coordinate activity in the neurogenic niche. Markwardt SJ, Dieni CV, Wadiche JI, Overstreet-Wadiche L Nat Neurosci 2011 In press

Keywords synapse, neurogenesis, epilepsy, hippocampus,

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