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Faculty Detail     Name JACQUES I. WADICHE   Campus Address SHEL 1005 Zip 2182 Phone 205-996-6413 E-mail jwadiche@uab.edu Other websites http://www.wadichelabs.com

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurobiology  Neurobiology Assistant Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor Center  Civitan International Research Center  Civitan International Research Center Assistant Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program

Biographical Sketch  Jacques Wadiche graduated with a B.A. in Neurobiology and Physiology from Northwestern University where he gained an appreciation for basic science research. From there he worked on nicotinic acetylcholine receptors at Baylor College of Medicine before enrolling in graduate school at the Vollum Institute at Oregon Health Sciences University in Portland, Oregon. His thesis work revealed how glutamate transporters can function as both carriers and ligand-gated ion channels. During his postdoctoral fellowship in Craig Jahr’s laboratory at the Vollum Institute, he studied a phenomenon where the release of several vesicles occur with each action potential at individual synapses. This results in a very high glutamate concentration in the synapse that can saturate postsynaptic receptors and ensure excitation of the postsynaptic neuron. His postdoctoral work also demonstrated how altering the strength of neuronal uptake can determine the extent of extrasynaptic receptor activation. He joined the faculty at UAB as an Assistant Professor in 2006. His laboratory continues to study mechanisms that regulate vesicular release and neuro-glial signaling.

Research/Clinical Interest Title Synaptic transmission and glutamate transporters Description Our research focuses on the details of fast synaptic transmission. Experiments in the lab incorporate a multidisciplinary approach of electrophysiological, imaging methods, and molecular biological approaches to study the activity of synapses and glutamate transporters. One model system that we use to study synaptic transmission and glutamate uptake are slices from cerebellum.

Selected Publications  Publication PUBMEDID Rudolph S., Overstreet-Wadiche L., Wadiche J.I. (2011) Desynchronization of multivesicular release enhances Purkinje cell output. Neuron, 70, 991-1004.  21658590  Markwardt S.J., Wadiche J.I., and Overstreet-Wadiche L.S. (2009) Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus. J Neurosci., 29:15063-72.  19955357  Tzingounis A.V. and Wadiche J.I. (2007) Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci., 8:935-47.  17987031  Wadiche J.I. and von Gersdorff H. (2006) Long-distance signaling via presynaptic glutamate transporters. Nat Neurosci., 9, 1352-3.   17066062  Wadiche, J.I., Tzingounis, A.V., and Jahr, C.E. (2006). Intrinsic kinetics determines the time course of neuronal synaptic transporter currents. PNAS, 103, 1083-7.  16418298  Wadiche, J.I. and Jahr, C.E. (2005). Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity. Nat. Neurosci., 8, 1329-34.  16136036  Kushmerick, C., Price, G., Tashenberger, H., Puente, N., Renden , R., Wadiche, J.I., Duvosin, R.M., Grandes, P., von Gersdorff, H. (2004). Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J. Neurosci., 24, 5955-65.  15229243  Wadiche, J.I. and Jahr, C.E. (2001). Multivesicular release at climbing fiber-Purkinje cell synapses. Neuron, 32, 301-13.  11683999  Wadiche, J.I. and Kavanaugh, M.P. (1998). Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J. Neurosci., 18, 7650-7661.  9742136  Wadiche, J.I., Arriza, J.L., Amara, S.G., and Kavanaugh, M.P. (1995). Kinetics of a human glutamate transporter. Neuron, 14, 1019-1027.  7748550  First Prev   1 2 of  2  Next Last

Keywords glutamate transport, synaptic transmission, cerebellum

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