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Faculty Detail     Name PHILLIP DOYLE SMITH   Campus Address SHEL 610 Zip 2182 Phone 205-934-6061 E-mail pdsmith@uab.edu Other websites Immunology

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Gastroenterology Professor Secondary  Microbiology  Microbiology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Center for AIDS Research  Center for AIDS Research Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor

Graduate Biomedical Sciences Affiliations Hughes Med-Grad Fellowship Program  Medical Scientist Training Program

Biographical Sketch  University of California, Berkeley, CA - B.A. University of Rochester, Rochester, NY - M.D. Vanderbilt University - Internship/Residency in Medicine University of Colorado - Gastroenterology Fellowship NIH (NIAID) - Post-doctoral Fellow (Parasite Immunology) NIH (NIDCR) - Senior Investigator University of Alabama at Birmingham- Mary J. Bradford Professor in Gastroenterology; Professor of Medicine and Microbiology; Director, Mucosal HIV and Immunobiology Center

Society Memberships Organization Name Position Held Org Link American Association of Immunologists      American Gastroenterological Association       Association of American Physicians      Society for Mucosal Immunology

Research/Clinical Interest Title Mucosal Immunity to Enteric Pathogens Description Dr. Smith's laboratory investigates the mucosalimmune responses to infectious agents and inflammatory stimuli. The mucosal cell functions currently being investigated include macrophage anergy, T regulatory and helper cell function, virus transcytosis, and the regulation of inflammation. The cellular and molecular basis for these responses are investigated by probing purified human intestinal, gastric and genital macrophages, lymphocytes, dendritic cells, T regulatory cells and epithelial cells with pathogens, including cytomegalovirus, HIV-1 and Helicobacter pylori or their purified or cloned products. The goal of these studies is to elucidate the cascade of events that regulate mucosal immune and inflammatory responses to enteric pathogens and stimuli. Understanding these responses is critical for developing novel therapeutic agents and vaccine strategies for mucosal diseases.

Selected Publications  Publication PUBMEDID Serrano, C., Wright, S.W., Bimczok, D., Shaffer, C.L., Cover, T.L., Venegas, A., Salazar, M.G., Smythies, L.E., Harris, P.R. and Smith, P.D. Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children. Mucosal Immunology doi: 10.1038/mi.2012.133. [Epub ahead of print], 2013  23299619  Shen, R., Meng, G., Ochsenbauer C., Clapham, P.R., Grams, J., Novak, L., Kappes, J.C., Smythies, L.E. and Smith, P.D. Stromal down-regulation of macrophage CD4/CCR5 expression and NF-kB activation mediates HIV-1 non-permissiveness in intestinal macrophages. PLoS Pathogens 7(5):e1002060, 2011. PMCID: PMC3102716.  21637819  Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M and Wahl SM. Intestinal macrophages and response to microbial encroachment. Mucosal Immunology 4:31-42, 2011.  20962772  Smythies, L.E., Sellers, M., Clements, R., Mosteller-Barnum, M., Meng, G., Benjamin, W.H., Orenstein, J.M. and Smith, P.D. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. Journal of Clinical Investigation 115:66-75, 2005. PMCID: PMC539188.  15630445  Meng, G., Wu, X., Wei, X., Sellers, M.T., Decker, J.M., Moldoveanu, Z., Kappes, J.C., Mestecky, J., Shaw, G.M. and Smith, P.D. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nature Medicine 8:150-156, 2002.  11821899  Smith PD, Fox CH, Masur H, Winter HS and Alling DW. Quantitative analysis of mononuclear cells expressing HIV-1 RNA in esophageal mucosa. Journal of Experimental Medicine. 180: 1541-1546, 1994.  7931086  Smith, P.D., Ohura, K., Masur, H., Lane, H.C., Fauci, A.S. and Wahl, S.M. Monocyte function in the acquired immune deficiency syndrome: Defective chemotaxis. Journal of Clinical Investigation 74:2121-2128, 1984. PMCID: PMC425403  6511917  Mai, U.E.H., Perez-Perez, G.I., Wahl, L.M., Wahl, S.M., Blaser, M.J. and Smith, P.D. Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by a lipopolysaccharide-independent mechanism. Journal of Clinical Investigation 87:894-900, 1991.  1847939  Mai, U.E.H., Perez-Perez, G.I., Allen, J.B., Wahl, S.M., Blaser, M.J. and Smith, P.D. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. Journal of Experimental Medicine 175: 517-525, 1992.  1732414  Smith, P.D., Saini, S.S., Raffeld, M., Manischewitz, J.F. and Wahl, S.M. Cytomegalovirus induces expression of tumor necrosis factor by human monocytes and mucosal macrophages. Journal of Clinical Investigation 90:1642-1648, 1992.  1331170

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