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Faculty Detail    
Name PALANIAPPAN SETHU
Associate Professor of Medicine and Biomedical Engineering
 
Campus Address MCLM 290A Zip 0005
Phone 205-975-4185
E-mail psethu@uab.edu
Other websites
     

Education
Undergraduate  PSG College of Technology    1998  B.E. Mechanical Engineering 
Graduate  University of Michigan    2000  M.S.E. Industrial Engineering 
Graduate  University of Michigan    2002  M.S. Biomedical Engineering 
Graduate  University of Michigan    2002  Ph.D. Biomedical Engineering 
Fellowship  Harvard Medical School, Massachusetts General Hospital and Shriners Burns Hospital    2005  Postdoctoral Fellowship 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Associate Professor

Graduate Biomedical Sciences Affiliations
Engineering 

Biographical Sketch 
Education:

1998-2002: Ph. D. Biomedical Engineering
University of Michigan, Ann Arbor, MI.
Advisor: Prof. Carlos H. Mastrangelo
Thesis: Plastic based microfluidic systems and their applications in biology and medicine.

2000-2002: M.S. Biomedical Engineering
University of Michigan, Ann Arbor, MI.

1998-2000: M.S.E. Industrial Engineering
University of Michigan, Ann Arbor, MI.

1994-1998: B.E. Mechanical Engineering
PSG College of Technology, Coimbatore, India.
Thesis: Design and fabrication of high efficiency axial flow fans for humidifiers in textile mills.

Professional Experience:

Sept 2013-present: Associate Professor
Division of Cardiovascular Disease, Department of Medicine and Biomedical Engineering
University of Alabama-Birmingham

Sept 2013-present: Adjunct Professor
Department of Bioengineering
University of Louisville

Jan 2012-Aug 2013: Associate Professor,
Department of Bioengineering
University of Louisville

Jan 2006-Dec 2011: Assistant Professor,
Department of Bioengineering
University of Louisville

Sept 2006-Aug 2013: Associate Appointment
Department of Mechanical Engineering
University of Louisville

June 2010-Aug-2013: Collaborating Investigator,
ElectroOptics Research Institute & Nanotechnology Center (ERINC)
University of Louisville

Jan 2009-present: Co-founder and Chief Scientific Officer
GeneStream Inc.

Sep 2009- present: Consultant
NaugaNeedles Inc. Louisville, KY

Jan 2006-Dec 2008: Visiting Fellow
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital.


Society Memberships
Organization Name Position Held Org Link
American Heart Association     
Biomedical Engineering Society     

Research/Clinical Interest
Title
Physiologically relevant models of cardiac and vascular tissue
Description
The focus of research activities in my laboratory is to create physiologically relevant in-vitro cellular level models of cardiac and vascular tissue. Using these models we seek to regenerate cardiac tissue using stem cells,develop platforms for drug discovery, testing and toxicity studies and recreate disease conditions. Our systems are unique as they accurately mimic mechanical stress signals generated during normal hemodynamic loading and unloading. Recreation of these stress signals is important as cardiac and vascular cells constantly experience hemodynamic stresses and rely on these signals to maintain normal phenotype and function.

Positions Available
Date Posted Position Title
8/19/2014  Graduate Student Research Assistant 
We currently have 1 position open for a PhD student to work on a project using our Cardiac Cell Culture Model. We are looking to create models of Left Ventricular Volume Overload using cardiomyocytes and cardiac fibroblasts. We are also looking to use the same system to study the effect of normal and heart failure conditions on immune cell phenotype and function. The ideal candidate should have cell culture experience and the ability to perform molecular assays and immunofluorescence microscopy.   

Selected Publications 
Publication PUBMEDID
Guruprasad Giridharan, Mai-Dung Nguyen, Vahidreza Parichehreh, Rosendo Estrada, Tariq Hamid, Mohammed Ismahil, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Cardiac Cell Culture Model”, Anal Chem. 2010 Sep 15;82(18):7581-7  20795703 
Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen, Thomas J. Roussel, Mostafa Shakeri, Vahidreza Parichehreh, Sumanth D. Prabhu and Palaniappan Sethu, “Endothelial Cell Culture Model (ECCM) for Replication of Physiological Profiles of Pressure, Flow, Strain and Shear Stress In-Vitro”, Anal Chem. 2011 Apr 15;83(8):3170-7  21413699 
Krishnakiran Medepalli, Bruce Alphenaar, Ashok Raj and Palaniappan Sethu, “Evaluation of the Direct and Indirect Response of Blood Leukocytes to Carbon Nanotubes (CNTs)”, Nanomedicine. 2011 Dec;7(6):983-91. Epub 2011 May 4  21616167 
Lorelei D. Shoemaker, Achal S. Achrol, Palaniappan Sethu, Gary K. Steinberg and Steven D. Chang, “Clinical Neuroproteomics and Biomarkers: From Basic Research to Clinical Decision-making”, Neurosurgery. 2012 Mar;70(3):518-25  21866062 
Balaji Panchapakesan, Palaniappan Sethu, Benjamin King, Brittany Book, Madhusuduna Rao and Joseph Irudayraj, “Gold Nanoprobes for Theranogstics”, Invited Review, Nanomedicine (Lond). 2011 Dec;6(10):1787-811  22122586 
Rosendo Estrada, Guruprasad Giridharan, Mai-Dung Nguyen, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Endothelial Cell Culture Model to Replicate Disturbed Flow Conditions Seen in Atherosclerosis Susceptible Regions”, Biomicrofluidics, 5, 032006, 2011   21413699 
Vahidreza Parichehreh and Palaniappan Sethu, “Inertial lift enhanced phase partitioning for continuous microfluidic charge based sorting of particles and cells”, Lab Chip. 2012 Mar 7;12(7):1296-301. Epub 2012 Feb 16  22336961 
Vahidreza Parichehreh, Krishnakiran Medepalli, Karan Babbarwal and Palaniappan Sethu, “Microfluidic Inertia Enhanced Phase Partitioning for Enriching Nucleated in Blood”, Lab Chip. 2013 Mar 7;13(5):892-900. doi: 10.1039/c2lc40663b. Epub 2013 Jan 10  23307172 
Kalyani Putty, Sarah A. Marcus, Peer R.E. Mittl, Lindsey E. Bogadi, Allison M. Hunter, Swathi Arur, Douglas E. Berg, Palaniappan Sethu, and Awdhesh Kalia, “Robustness of H. pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich Paralogs”,PLoS ONE 8(3): e59560. doi:10.1371/journal.pone.0059560  23555707 
Krishnakiran Medepalli, Bruce W. Alphennar, Robert S. Keynton and Palaniappan Sethu, “A new technique for reversible permeablization of live cells for delivery of quantum dots”, Nanotechnology. 2013 May 24;24(20):205101. doi: 10.1088/0957-4484/24/20/205101. Epub 2013 Apr 19  23598366 
Phanikumar Patibandla, Rosendo Estrada, Manasaa Kannan and Palaniappan Sethu, “A Microfluidics Based Technique for Automated and Rapid Labeling of Cells for Flow Cytometry”, Journal of Micromechanics and Microengineering, Volume 24, Issue 3, Pages 034002, Jan 2014   
Mai-Dung Nguyen, Joseph P. Tinney, Fanping Yuan, Thomas J. Roussel, Ayman El-Baz, Guruprasad Giridharan, Bradley B. Keller and Palaniappan Sethu, “Cardiac Cell Culture Model (CCCM) as a Left Ventricle Mimic for Cardiac Tissue Generation”, Anal Chem. 2013 Aug 16.  23952579 
Xiaoyan Zhang, Ran Cheng, Dylan Rowe, Palaniappan Sethu, Alan Daugherty, Guoqiang Yu, and Hainsworth Shin “The shear-sensitive regulation of neutrophil flow behavior and its putative role in microvascular blood flow dysregulation in hypercholesterolemia”, Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):587-93. doi: 10.1161/ATVBAHA.113.302868. Epub 2014 Jan 23  24458712 
Ralph J. Knipp, Rosendo Estrada, Palaniappan Sethu and Michael H. Nantz, “Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates”, Tetrahedron, 70, 3422-3429  25061237 

Keywords
cardiac and vascular models, mechanical stresses, cardiac regeneration, normal and disturbed flow