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Faculty Detail     Name KEVIN AARON ROTH   Campus Address WP P210 Zip 7331 Phone 205-934-5802 E-mail karoth@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pathology   Pathology Gen Administration Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Neurobiology  Neurobiology Professor Center  Center for Aging  Center for Aging Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Integrative Biomedical Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program  Molecular and Cellular Pathology Program  Neuroscience  Neuroscience Graduate Program  Neurosciences

Biographical Sketch  Dr. Roth graduated with highest honor from the University of Michigan and received his M.D. and Ph.D. in neuroscience from Stanford University School of Medicine. He completed his pathology residency and neuropathology fellowship at Washington University in St. Louis before joining the Washington University faculty in 1989. He was selected Lecturer of the Year three times, received seven Distinguished Teaching Service Awards, and was promoted to the rank of full professor in the Departments of Pathology and Immunology, and Molecular Biology and Pharmacology at Washington University in 2001. Dr. Roth moved to UAB in 2002 and served as Director of the Division of Neuropathology until his appointment as Chair of Pathology in 2008. He was the founding Director of the UAB Comprehensive Neuroscience Center and he currently serves as Director of the Alabama Neuroscience Blueprint Center and as the Robert and Ruth Anderson Professor and Chair of the Department of Pathology.

Society Memberships Organization Name Position Held Org Link American Association of Neuropathologists    www.neuropath.org  American Society for Investigative Pathology  Councilor; Associate Editor, American Journal of Pathology  www.asip.net  Histochemical Society  Associate Editor, Journal of Histochemistry and Cytochemistry  www.histochemicalsociety.org  Society for Neuroscience    www.sfn.org

Research/Clinical Interest Title Molecular Regulation of Neuronal Cell Death Description Research in my laboratory is focused on the regulation of neuronal apoptosis. Neuronal apoptosis occurs during normal nervous system development and in a variety of neuropathological processes including hypoxic/ischemic injury and neurodegenerative diseases. We have used mice with targeted gene disruptions of specific bcl-2 and caspase family members, in combination with a variety of in vivo and in vitro models of neuronal cell death, to define the cell- and stimulus-specific molecular pathways of cell death. We have demonstrated that normal nervous system development is regulated by APAF-1-, caspase-9-, and caspase-3-dependent apoptosis of neural precursor cells and Bax:Bcl-XL-dependent apoptosis of immature neurons. Neural precursor cell apoptosis also plays an important role in preventing neural tumorigenesis and is triggered by DNA damage. The long-term goals of my laboratory are to define the molecular pathways of apoptotic and autophagic neuronal death during brain development and in neuropathological conditions and to subsequently design pharmacological strategies for affecting the death process. Such studies will yield significant new data on the cellular and molecular regulation of neuronal cell death and hopefully, provide insights into the prevention and treatment of strokes, neurodegenerative diseases and brain tumors.

Selected Publications  Publication PUBMEDID Roth, KA: The American Journal of Pathology Centennial Project: Celebrating 100 Years of the American Society for Investigative Pathology. Am. J. Pathol. 2012; 180:1337-1339.  22386770  Kohli L, Kaza N. Lavalley NJ, Turner KL, Byer S, Carroll SL, Roth KA: The pan erbB Inhibitor PD168393 Enhances Lysosomal Dysfunction-Induced Apoptotic Death in Malignant Peripheral Nerve Sheath Tumor Cells. Neuro-Oncology, 2012; 14(3):266-277. PMCID: PMC3280808  22259051  Kaza N, Kohli L, Roth KA: Autophagy in Brain Tumors: A New Target for Therapeutic Intervention. Brain Pathol. 2012; 22:89-98. PMCID: PMC3243074  22150924  Ghosh AP, Cape JD, Klocke BJ, Roth KA: Deficiency of Pro-apoptotic Hrk Attenuates Programmed Cell Death in the Developing Murine Nervous System But Does Not Affect Bcl-x Deficiency-Induced Neuron Apoptosis. J. Histochem. Cytochem. 2011 Nov;59(11):976-83. PMCID: PMC3261623  22043021  Pivtoraiko V, Harrington AJ, Mader BJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shack JJ: Low-Dose Bafilomycin Attenuates Neuronal Cell Death Associated with Autophagy-Lysosome Pathway Dysfunction. J. Neurochem. J Neurochem. 2010 Aug;114(4):1193-1204. PMCID: PMC2910188  20534000  Christensen HM, Dikranian K, Li A, Baysac KC, Walls KC, Olney JW, Roth KA, Harris DA: A Highly Toxic Cellular Prion Protein Induces a Novel, Non-Apoptotic Form of Neuronal Death. Am. J. Pathol. 2010; 176(6)2695-2706. PMCID: PMC2877832  20472884  Geng Y, Kohli L, Klocke BJ, Roth KA: Chloroquine-Induced Autophagic Vacuole Accumulation and Cell Death in Glioma Cells is p53 Independent. Neuro-Oncology 2010; 12(5):473-481. PMCID: PMC2940627  20406898  Kohli L and Roth KA: Autophagy – Cerebral Home Cooking. Am. J. Pathol. 2010; 176:1065-1071. PMCID: PMC2832126  20150434  Walls KC, Ghosh AP, Franklin AL, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA: Lysosome Dysfunction Triggers Atg7-Dependent Neural Apoptosis. J. Biol. Chem. 2010; 285(14):10497-10507. PMCID: PMC2856257  20123985  Cohn SM, Roth KA, Birkenmeier EH, Gordon JI: Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization and differentiation of the intestinal epithelium. Proc. Natl. Acad. Sci. (USA) 1991; 88:1034-1038. PMID: 19922454  19922454  First Prev   1 2 3 4 5 6 7 8 9 10 of  20  Next Last

Keywords Apoptosis, Autophagy, Bcl-2, Caspases, Neurodegenerative Disease, Neuropathology, Programmed cell death

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