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Faculty Detail     Name CHANDER RAMAN   Campus Address SHEL 305 Zip 2182 Phone 205-934-2472 E-mail craman@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Immunology/Rheumatology Professor Secondary  Microbiology  Microbiology Assistant Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Immunology  Medical Scientist Training Program  Neuroscience

Biographical Sketch  Chander Raman (b. 1961), Assistant Professor of Medicine, received his B.Sc. degree in Zoology from Madras University, India (1980). He subsequently received his M.S. degree in Microbiology from Idaho State University (1984) and Ph.D. degree in Microbiology from Southern Illinois University (1989) with special emphasis in immunology and host responses to infectious diseases. During his postdoctoral training with Dr. Katherine Knight at Loyola University Chicago, Stritch School of Medicine (1984-1989), he developed an interest in immunogenetics and regulation of lymphocyte activation. He continued his studies first as an Assistant Scientist at Hospital For Special Surgery, Cornell University Medical College (1994-1996) and more recently as an Assistant Professor in the Department of Medicine in the Division of Clinical Immunology and Rheumatology. He also has a secondary appointment in the Department of Microbiology.

Research/Clinical Interest Title Lymphocyte activation, immunopathogenesis of autoimmune diseases Description The projects in the laboratory are: (1) Role of CD5 in B-cell and T-cell development, differentiation, immunity and pathogenesis - related to this project we focus on B-1a B-cells, T-independent antibody responses, T-dependent antibody responses, autoreactive B-cell generation and persistence and regulatory B-cells. In this research area, my laboratory for several years has been interested in determining the physiological and biochemical activities of CD5, a regulator of activation in B-1a B-cells and T-cells. (2) Immunopathogenesis of MS – related to this project we focus on mechanisms regulating the activation of T-cells and differentiation to pathogenic (Th1, Th17 and ThIFNγIL-17 –dual producers), regulatory (nTreg, iTreg) Th subsets and cells of the innate immune system (dendritic cells, macrophages and microglia). Within this context a new area for the laboratory is the study of type 1 and type 2 interferons in the pathogenesis of MS and the mouse model, experimental autoimmune encephalomyelitis (EAE). (3) Therapeutic targeting of MS. All of the projects involved the study of signaling pathways driving the differentiation of both pathogenic and regulatory effector populations following stimulation of TLR and/or cytokine receptors.

Selected Publications  Publication PUBMEDID John, B., Herrin, B. R., Raman, C., Wang, Y., Elder, H.K., Bobbit, K. R., Brody, B. A., and Justement, L. B. 2003. The B cells co-receptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immunol. 170:3534-3543.  12646615  Raman, C. 2002. CD5, an important regulator of lymphocyte selection and tolerance. Immunol. Res. 26:179-187  12403363  Lu, X., Axtell, R. A., Collawn, J. F., Gibson, A., Justement, L. B., and Raman, C. 2002. AP2 Adaptor complex-dependent internalization of CD5: Differential regulation in T and B cells. J. Immunol.. 168:5612-5620.  12023358  Greer, S. F., Raman, C. and Justement, L. B. 2001. CD45 function is regulated by an acidic 19 amino acid insert in domain II that serves as bidning and phosphoacceptor site for CK2. J. Immunol. 166:7208-7218.  11390469  Raman, C. and Kimberly, R. P. 1998. Differential CD5-dependent regulation of CD5-associated CK2 acitivity in mature and immature T cells – Implications on TCR/CD3-mediated activation. Cutting Edge-J. Immunol. 161-5817-5820.  9834058  Raman, C., Kuo, A., Deshane, J., Litchfield, D. W., and Kimberly, R. P. Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5. 1998. J. Biol. Chem. 273:19183-19189.v  9668105

Keywords Autoimmunity, Multiple Sclerosis, CD5, IFNs, CK2

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