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Faculty Detail    
Name CHANDER RAMAN
 
Campus Address SHEL 305 Zip 2182
Phone 205-934-2472
E-mail craman@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Immunology/Rheumatology Professor
Secondary  Microbiology  Microbiology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Immunology 
Medical Scientist Training Program 
Neuroscience 

Biographical Sketch 
Chander Raman (b. 1961), Assistant Professor of Medicine, received his B.Sc. degree in Zoology from Madras University, India (1980). He subsequently received his M.S. degree in Microbiology from Idaho State University (1984) and Ph.D. degree in Microbiology from Southern Illinois University (1989) with special emphasis in immunology and host responses to infectious diseases. During his postdoctoral training with Dr. Katherine Knight at Loyola University Chicago, Stritch School of Medicine (1984-1989), he developed an interest in immunogenetics and regulation of lymphocyte activation. He continued his studies first as an Assistant Scientist at Hospital For Special Surgery, Cornell University Medical College (1994-1996) and more recently as an Assistant Professor in the Department of Medicine in the Division of Clinical Immunology and Rheumatology. He also has a secondary appointment in the Department of Microbiology.

Research/Clinical Interest
Title
Lymphocyte activation, immunopathogenesis of autoimmune diseases
Description
The projects in the laboratory are: (1) Role of CD5 in B-cell and T-cell development, differentiation, immunity and pathogenesis - related to this project we focus on B-1a B-cells, T-independent antibody responses, T-dependent antibody responses, autoreactive B-cell generation and persistence and regulatory B-cells. In this research area, my laboratory for several years has been interested in determining the physiological and biochemical activities of CD5, a regulator of activation in B-1a B-cells and T-cells. (2) Immunopathogenesis of MS – related to this project we focus on mechanisms regulating the activation of T-cells and differentiation to pathogenic (Th1, Th17 and ThIFNγIL-17 –dual producers), regulatory (nTreg, iTreg) Th subsets and cells of the innate immune system (dendritic cells, macrophages and microglia). Within this context a new area for the laboratory is the study of type 1 and type 2 interferons in the pathogenesis of MS and the mouse model, experimental autoimmune encephalomyelitis (EAE). (3) Therapeutic targeting of MS. All of the projects involved the study of signaling pathways driving the differentiation of both pathogenic and regulatory effector populations following stimulation of TLR and/or cytokine receptors.

Selected Publications 
Publication PUBMEDID
Raman, C. and Kimberly, R. P. 1998. Differential CD5-dependent regulation of CD5-associated CK2 acitivity in mature and immature T cells – Implications on TCR/CD3-mediated activation. Cutting Edge-J. Immunol. 161-5817-5820.  9834058 
Raman, C., Kuo, A., Deshane, J., Litchfield, D. W., and Kimberly, R. P. Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5. 1998. J. Biol. Chem. 273:19183-19189.v  9668105 
John, B., Herrin, B. R., Raman, C., Wang, Y., Elder, H.K., Bobbit, K. R., Brody, B. A., and Justement, L. B. 2003. The B cells co-receptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immunol. 170:3534-3543.  12646615 
Raman, C. 2002. CD5, an important regulator of lymphocyte selection and tolerance. Immunol. Res. 26:179-187  12403363 
Lu, X., Axtell, R. A., Collawn, J. F., Gibson, A., Justement, L. B., and Raman, C. 2002. AP2 Adaptor complex-dependent internalization of CD5: Differential regulation in T and B cells. J. Immunol.. 168:5612-5620.  12023358 
Greer, S. F., Raman, C. and Justement, L. B. 2001. CD45 function is regulated by an acidic 19 amino acid insert in domain II that serves as bidning and phosphoacceptor site for CK2. J. Immunol. 166:7208-7218.  11390469 

Keywords
Autoimmunity, Multiple Sclerosis, CD5, IFNs, CK2