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Faculty Detail    
Name DEBRA CROSS QUENELLE
 
Campus Address CHB 128 Zip 0011
Phone 205-934-1990
E-mail dquenell@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pediatrics   Ped - Infectious Disease Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor

Biographical Sketch 
Dr. Quenelle’s research interests involve animal models of human infectious diseases, particularly for efficacy testing of novel compounds and immunotherapies. She received her B.S., M.S., D.V.M., and Ph.D. from Auburn University. She has published over 40 manuscripts using animal models of human herpes viruses, orthopox viruses, tuberculosis, and HIV.

Research/Clinical Interest
Title
Description
Currently, Dr. Quenelle manages the NIH, NIAID AO1 Task Order “Mouse and Guinea Pig Models for Herpesvirus” at UAB which tests new antiviral therapies in rodent models using HSV-1, HSV-2, and CMV infections. She also conducts investigations for private sponsors using similar models.

Selected Publications 
Publication PUBMEDID
Prichard MN, Quenelle DC, Hartline CB, Harden EA, Jefferson G, Frederick SL, Daily SL, Whitley RJ, Tiwari KN, Maddry JA, Secrist JA, Kern ER. Inhibition of Herpesvirus replication by 5-substituted 4′ thiopyrimidine nucleosides. Antimicrobial Agents and Chemotherapy, 53:5251-5258, 2009.   9770274 
Li, C, Quenelle DC, Prichard MN, Drach JC, Zemlicka J. Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir. Bioorganic and Medicinal Chemistry, 20(8): 2669-2674, 2012.   22417649 
Markert J, Cody J, Parker J, Coleman J, Price K, Kern E, Quenelle D, Lakeman F, Schoeb T, Palmer C, Cartner S, Gillespie G, Whitley R. Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing IL-12. Journal of Virology, 86 (9): 5304-5313, 2012.   22379082 
Quenelle DC, Collins DJ, Rice TL, Rahman A, Glazer R. Efficacy of orally administered low dose N-methanocarbathymidine (N-MCT) against lethal HSV-2 infections of mice. Antiviral Chemistry and Chemotherapy, 22:131-137, 2011.   22095521 
Quenelle DC, Kern ER Treatment of vaccinia and cowpox infections in mice with CMX001 and ST-246. Viruses, 2: 2681-2695, 2010.   21994637 
Quenelle DC, Lampert B, Collins DJ, Rice TL, Painter GR, Kern ER. Efficacy of CMX001 against Herpes simplex virus infections in mice and correlations with drug distribution studies. Journal Infectious Diseases, 202:1492-1499, 2010.  20923374 
Kern ER, Prichard MN, Quenelle DC, Keith KA, Tiwari KN, Maddry JA, Secrist JA. Activity of certain 5-substituted 4′ thiopyrimidine nucleosides against orthopoxvirus infections. Antimicrobial Agents and Chemotherapy, 53:572-579, 2009.  19029322 
Quenelle DC, Collins DJ, Rice TL, Prichard MN, Marciani DJ, Kern ER. Effect of An Immune Enhancer, GPI-0100, on Vaccination With Live Attenuated Herpes Simplex Virus (HSV) Type 2 or Glycoprotein D on Genital HSV-2 Infections of Guinea Pigs. Antiviral Reseach, 80:223-224, 2007.   18573279 
Quenelle DC, Collins DJ, Herrod BP, Keith KA, Trahan J, Beadle JR, Hostetler KY, Kern ER. Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice. Antimicrobial Agents and Chemotherapy, 51:3940-3947, 2007.   17846137 
Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER. Synergistic Efficacy of the Combination ST-246 with CMX001 against Orthopoxviruses. Antimicrobial Agents and Chemotherapy, 51:4118-4134, 2007.   17724153 
Quenelle DC, Buller RML, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER. Efficacy of Delayed Treatment of ST-246 Given Orally Against Systemic Orthopoxvirus Infections in Mice. Antimicrobial Agents and Chemotherapy, 51:689-695, 2007.   17116683 
Quenelle DC, Keith KA, Kern ER. In vitro and in vivo evaluation of isatin-β-thiosemicarbazone and marboran for vaccinia or cowpox virus infections. Antiviral Reseach, 71:24-30, 2006.  16621041 
Parker JN, Pfister LA, Quenelle D, Gillespie GY, Markert JM, Kern ER, Whitley RJ. Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates. Vaccine, 24:1644-52, 2006.   16243413 
Quenelle DC, Collins DJ, Kern ER. Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir. Antiviral Research, 63:33-40, 2004.   15196818 
Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER. Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. Antimicrobial Agents and Chemotherapy, 48:404-412, 2004.  14742188 
Quenelle DC, Collins DJ, Kern ER. Efficacy of multiple and single dose cidofovir in vaccinia and cowpox virus infections of mice. Antimicrobial Agents and Chemotherapy, 47: 201-203, 2003.   14506041