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Faculty Detail     Name DEBRA CROSS QUENELLE   Campus Address CHB 128 Zip 0011 Phone 205-934-1990 E-mail dquenell@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pediatrics   Ped - Infectious Disease Associate Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor

Biographical Sketch  Dr. Quenelle’s research interests involve animal models of human infectious diseases, particularly for efficacy testing of novel compounds and immunotherapies. She received her B.S., M.S., D.V.M., and Ph.D. from Auburn University. She has published over 40 manuscripts using animal models of human herpes viruses, orthopox viruses, tuberculosis, and HIV.

Research/Clinical Interest Title Description Currently, Dr. Quenelle manages the NIH, NIAID AO1 Task Order “Mouse and Guinea Pig Models for Herpesvirus” at UAB which tests new antiviral therapies in rodent models using HSV-1, HSV-2, and CMV infections. She also conducts investigations for private sponsors using similar models.

Selected Publications  Publication PUBMEDID Li, C, Quenelle DC, Prichard MN, Drach JC, Zemlicka J. Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir. Bioorganic and Medicinal Chemistry, 20(8): 2669-2674, 2012.   22417649  Markert J, Cody J, Parker J, Coleman J, Price K, Kern E, Quenelle D, Lakeman F, Schoeb T, Palmer C, Cartner S, Gillespie G, Whitley R. Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing IL-12. Journal of Virology, 86 (9): 5304-5313, 2012.   22379082  Quenelle DC, Collins DJ, Rice TL, Rahman A, Glazer R. Efficacy of orally administered low dose N-methanocarbathymidine (N-MCT) against lethal HSV-2 infections of mice. Antiviral Chemistry and Chemotherapy, 22:131-137, 2011.   22095521  Quenelle DC, Kern ER Treatment of vaccinia and cowpox infections in mice with CMX001 and ST-246. Viruses, 2: 2681-2695, 2010.   21994637  Quenelle DC, Lampert B, Collins DJ, Rice TL, Painter GR, Kern ER. Efficacy of CMX001 against Herpes simplex virus infections in mice and correlations with drug distribution studies. Journal Infectious Diseases, 202:1492-1499, 2010.  20923374  Kern ER, Prichard MN, Quenelle DC, Keith KA, Tiwari KN, Maddry JA, Secrist JA. Activity of certain 5-substituted 4′ thiopyrimidine nucleosides against orthopoxvirus infections. Antimicrobial Agents and Chemotherapy, 53:572-579, 2009.  19029322  Quenelle DC, Collins DJ, Rice TL, Prichard MN, Marciani DJ, Kern ER. Effect of An Immune Enhancer, GPI-0100, on Vaccination With Live Attenuated Herpes Simplex Virus (HSV) Type 2 or Glycoprotein D on Genital HSV-2 Infections of Guinea Pigs. Antiviral Reseach, 80:223-224, 2007.   18573279  Quenelle DC, Collins DJ, Herrod BP, Keith KA, Trahan J, Beadle JR, Hostetler KY, Kern ER. Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice. Antimicrobial Agents and Chemotherapy, 51:3940-3947, 2007.   17846137  Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER. Synergistic Efficacy of the Combination ST-246 with CMX001 against Orthopoxviruses. Antimicrobial Agents and Chemotherapy, 51:4118-4134, 2007.   17724153  Quenelle DC, Buller RML, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER. Efficacy of Delayed Treatment of ST-246 Given Orally Against Systemic Orthopoxvirus Infections in Mice. Antimicrobial Agents and Chemotherapy, 51:689-695, 2007.   17116683  First Prev   1 2 of  2  Next Last

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