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Faculty Detail    
Name EMMA PEREZ-COSTAS
 
Campus Address SC 865C Zip 0017
Phone 205-996-9374
E-mail epcostas@uab.edu
Other websites http://www.researchgate.net/profile/Emma_PEREZ-COSTAS/
http://goo.gl/V8rBR
http://community.frontiersin.org/people/EMMAPEREZ-COSTAS/22138
http://www.uab.edu/medicine/neurobiology/faculty/78-ecostas
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Secondary  Neurobiology  Neurobiology Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Neuroscience 

Biographical Sketch 
-Bachelor in Science, Biology (1996). University of Santiago de Compostela, Spain
-Master in Science, Cell Biology (1998). University of Santiago de Compostela, Spain.
-PhD, Cell Biology/Neuroscience (2002). University of Santiago de Compostela, Spain.
-Postdoctoral Fellow (2003-2006), Maryland Psychiatric Research Center. University of Maryland, School of Medicine.
-Faculty Instructor (2006-2007), Maryland Psychiatric Research Center. University of Maryland, School of Medicine.
-Assistant Professor (2007-present), University of Alabama at Birmingham.

Society Memberships
Organization Name Position Held Org Link
AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE  REGULAR MEMBER  http://www.aaas.org 
ASOCIACION DE BIOLOGOS DE GALICIA (Galcian Biologists Association)  REGULAR MEMBER  http://www.biologosdegalicia.org 
FACULTY FOR UNDERGRADUATE NEUROSCIENCE  REGULAR MEMBER  http://www.funfaculty.org 
SOCIETY FOR NEUROSCIENCE  REGULAR MEMBER  http://www.sfn.org 

Research/Clinical Interest
Title
ASSISTANT PROFESSOR
Description
-The dopaminergic mesocortical pathway and its impact in cortical function in neurological and neuropsychiatric disorders.
-Characterization of novel animal models for the study of human brain pathology.
-Adaptation or development of new histological techniques.
-Development of the mesodiencephalic dopaminergic system

Funded Research:
12/2010-11/2015 Principal Investigator (MPI), Neuropathology of Dopamine Systems in Schizophrenia, funded by National Institutes of Mental Health (RO1MH066123)

People in the Lab
-Matthew W. Rice, Graduate Student, email:stvanek@uab.edu
-Kristen L. Smith, Undergraduate Student, Neuroscience and Science and Technology Honors Programs, UAB. email: kls93@uab.edu Watch Kristen explaining some of her work in the lab: Kristen explains work LAB ALUMNI: -Iria Gonzalez-Dopeso Reyes, PhD: iriagonzalez@unav.es (currently Postdoctoral Researcher at University of Navarra, Spain) -Ryan P. Lee, Undergraduate Student, Neuroscience and Science and Technology Honors Programs, UAB. email: panthera@uab.edu

Selected Publications 
Publication PUBMEDID
Anadon R, Melendez-Ferro M, Perez-Costas E, Pombal MA, Rodicio MC (1998) Centrifugal fibers are the only GABAergic structures of the retina of the larval sea lamprey: an immunocytochemical study., Brain Research, 782 (1-2), 297-30  9519276 
Gandy JC, Melendez-Ferro M, Bijur GN, Van Leuven F, Roche JK, Lechat B, Devijver H, Demedts D, Perez-Costas E*, Roberts RC* (2013) Glycogen synthase kinase-Beta;(GSK3-B) expression in a mouse model of Alzheimer's disease: A light and electron microscopy study. Synapse. 2013 Feb 7. doi: 10.1002/syn.21642. [Epub ahead of print]
[*Co-corresponding authors] 
23390016 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E (2012) Dual use of immunohistochemistry for film densitometry and light microscopy. J Neurosci Methods, 208(1):86-91  22579877 
Perez-Costas E, Melendez-Ferro M, Rice MW, Conley RR, Roberts RC (2012) Dopamine pathology in schizophrenia: Analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. Front. Psychiatry 3:31. doi: 10.3389/fpsyt.2012.00031  22509170 
Rice MW, Roberts RC, Melendez-Ferro M, Perez-Costas E (2011) Neurochemical characterization of the tree shrew dorsal striatum. Frontiers in Neuroanatomy 2011;5:53.
 
21887131 
Perez-Costas E, Gandy JC, Melendez-Ferro M, Roberts RC, Bijur GN (2010). Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One 5(1):e8911.  20111716 
Perez-Costas E, Melendez-Ferro M, Roberts RC (2010) Basal ganglia pathology in schizophrenia: dopamine connections and anomalies. Journal of Neurochemistry, 113(2):287-302  20089137 
Melendez-Ferro M, Perez-Costas E, Roberts RC (2009) A new use for long-term frozen brain tissue: Golgi impregnation. Journal of Neuroscience Methods, 176(2):72-7  18789970 
Abalo XM, Villar-Cheda B, Meléndez-Ferro M, Pérez-Costas E, Anadón R, Rodicio MC (2007) Development of the serotonergic system in the central nervous system of the sea lamprey., Journal of chemical neuroanatomy, 34 (1-2), 29-46  17485194 
Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Holstein GR, Martinelli GP, Rodicio MC, Anadon R (2006) Presence of glutamate, glycine and GABA in the retina of the larval sea lamprey: a comparative immunohistochemical study of the classical neurotransmitters in the larval and postmetamorphic retinas, The Journal of Comparative Neurology, 499: 810-827  17048230 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Abalo XM, Rodriguez-Munoz R, Anadon R, Rodicio MC (2006) Cell proliferation of the forebrain and midbrain of the sea lamprey, The Journal of Comparative Neurology, 494: 986-1006  16385485 
Rodicio MC, Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Anadon R (2005) Chemoarchitecture of the dorsal column of the larval sea lamprey, Brain Research Bulletin, 66 (536-540)  16144645 
Perez-Costas E, Melendez-Ferro M, Perez-Garcia CG, Caruncho HJ, Rodicio MC (2004) Reelin immunoreactivity in the adult sea lamprey brain, Journal of Chemical Neuroanatomy, 27 (7-21)  15036359 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Rodriguez-Munoz R, Anadon R, Rodicio MC (2003) Ontogeny of gamma-aminobutyric acid-immunoreactive neurons in the rhombencephalon and spinal cord of the sea lamprey., The Journal of Comparative Neurology, 464 (1), 17-35.  12866126 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Abalo XM, Rodriguez-Munoz R, Rodicio MC, Anadon R (2002) Ontogeny of gamma-aminobutyric acid-immunoreactive neuronal populations in the forebrain and midbrain of the sea lamprey., The Journal of Comparative Neurology, 446 (4), 360-76  11954035 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Manoel Abalo X, Rodriguez-Munoz R, Anadon R, Celina Rodicio M (2002) Proliferating cell nuclear antigen (PCNA) immunoreactivity and development of the pineal complex and habenula of the sea lamprey, Brain Research Bulletin, 57(3-4), 285-7.  11922973 
Perez-Costas E, Melendez-Ferro M, Santos Y, Anadon R, Rodicio MC, Caruncho HJ (2002) Reelin immunoreactivity in the larval sea lamprey brain., Journal of Chemical Neuroanatomy, 23 (3), 211-21  11861127 
Melendez-Ferro M, Villar-Cheda B, Manoel Abalo X, Perez-Costas E, Rodriguez-Munoz R, Degrip WJ, Yanez J, Rodicio MC, Anadon R (2002) Early development of the retina and pineal complex in the sea lamprey: comparative immunocytochemical study., The Journal of Comparative Neurology, 442 (3), 250-65  11774340 
Melendez-Ferro M, Perez-Costas E, Rodriguez-Munoz R, Gomez-Lopez MP, Anadon R, Rodicio MC (2001) GABA immunoreactivity in the olfactory bulbs of the adult sea lamprey Petromyzon marinus L., Brain Research, 893 (1-2), 253-60.  11223013 
Melendez-Ferro M, Perez-Costas E, Gonzalez MJ, Pombal MA, Anadon R, Rodicio MC (2000) GABA-immunoreactive internuclear neurons in the ocular motor system of lampreys., Brain Research, 855 (1), 150-7  10650142 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E (2013) An accurate method for the quantification of cytochrome C oxidase in tissue sections. J Neurosci Methods. 2013 Jan 30. pii: S0165-0270(13)00030-7. doi: 10.1016/j.jneumeth.2013.01.010. [Epub ahead of print]  23376420 
Barksdale KA, Perez-Costas E, Gandy CG, Melendez-Ferro M, Roberts RC, Bijur GN (2010) Mitochondria viability in mouse and human postmortem brain. FASEB Journal, 24(9): 3590-9  20466876 
Perez-Costas E, Guidetti P, Melendez-Ferro M, Kelley JJ, Roberts RC (2008) Neuroleptics and animal models: feasibility of oral treatments monitored by plasma levels and receptor occupancy assays, The Journal of Neural Transmission,115(5):745-53  18193153 
Roberts RC, Perez-Costas E (2008) Ultrastructural localization of reelin. In: “Reelin glycoprotein: biology structure and roles” (1st Edition), USA, Fatemi SH (Ed), Springer-Verlag, ISBN: 978-0-387-76760-4. ISBN=9780387767604 [bookchapter; chapter 8]   
Perez-Costas E, Melendez-Ferro M, Roberts RC (2007) Microscopy techniques and the study of synapses In A. Mendez-Vilas, J. Diaz (eds), Modern Research and Educational Topics in Microscopy, 3rd edition, Badajoz, Spain, Formatex, ISBN=9788461194193 (Book Chapter)   

Keywords
neuroanatomy, neuropathology, dopamine systems, neurobiology, neuronal development, neurological disorders, neuropsychiatric disorders