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Faculty Detail    
Name ANTHONY P NICHOLAS
Assistant Chief of Neurology, Birmingham VA Medical Center
Director, Neurology Clerkship Program
Co-Director, Medical Neuroscience Course Module
 
Campus Address SC 350G Zip 0017
Phone 205-996-7777
E-mail nicholas@uab.edu
Other websites http://www.youtube.com/user/DrNicksBrainChannel/videos
Career Advisor     

Education
Undergraduate  University of Scranton, Scranton, Pennsylvania    1982  B.S. 
Graduate  Graduate School of Biomedical Sciences, Galveston, Texas    1987  Ph.D. 
Medical School  The University of Texas Medical Branch, Galveston, Texas    1990  M.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurology   Neurology Chair Office Professor
Secondary  Neurobiology  Neurobiology Assistant Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor

Graduate Biomedical Sciences Affiliations
Hughes Med-Grad Fellowship Program 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Neuroscience Graduate Program 
Neurosciences 

Biographical Sketch 
Dr. Nicholas is originally from Pennsylvania and received his B.S. degree in 1982 from the University of Scranton. He then received his Ph.D. in Anatomy from the Graduate School of Biomedical Sciences in Galveston in 1987, and his M.D. degree from the University of Texas Medical Branch at Galveston in 1990. After medical school, Dr. Nicholas spent two years completing a post-doctoral fellowship in Neuroscience with Dr. Tomas Hökfelt at the Karolinska Institute in Stockholm, Sweden. In 1992, he returned to the United States and in 1996 concluded his neurology residency and became Assistant Professor of Neurology at UAB. He was promoted to Associate Professor in 2003 and presently holds joint appointments in the Departments of Neurobiology and Physiology/Biophysics. He also serves as Assistant Chief of Neurology at the Birmingham VA Medical Center, was Co-Director of the American Parkinson Disease Association Information and Referral Center at UAB and Director of the UAB Parkinson Disease Research Laboratory from 1997-2005. In 2006, Dr. Nicholas was given research appointments in the Civitan International Research Center and UAB's Center for Glial Biology in Medicine and Center for Neurodegeneration and Experimental Therapeutics.

Society Memberships
Organization Name Position Held Org Link
American Academy of Neurology  Member   
American Neurological Association  Member   
Movement Disorders Society  Member   
Society for Neuroscience  Member   

Research/Clinical Interest
Title
Parkinsonís Disease, Citrullinated Proteins, Adrenergic Receptors
Description
Major basic science research interests of Dr. Nicholas include the pathophysiology of Parkinsonís disease, including protein degradation and the role of auto-immune antibodies and gliosis in neurodegeneration. Other interests include the neurochemical mechanisms responsible for levodopa-induced dyskinesia and the role of protein deimination (citrullination) in neurological diseases such as Parkinsonís disease, Alzheimerís disease and multiple sclerosis (and their animal models). Dr. Nicholas also has experience performing clinical research, including testing new treatments for Parkinson's disease, multiple sclerosis and cervical dystonia.

Selected Publications 
Publication PUBMEDID
Nicholas AP, Hökfelt T, Pieribone VA: The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends in Pharmacological Sciences 17 :245-255, 1996.  8756183 
Nicholas AP, Pieribone V, Hökfelt T: Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. Journal of Comparative Neurology, 328: 585-604, 1993.  8381444 
Nicholas AP, Pieribone VA, Hökfelt T: Cellular localization of mRNA for beta-1 and beta-2 adrenergic receptors in rat brain: an in situ hybridization study. Neuroscience, 56: 1023-1039, 1993.  8284033 
Pieribone VA, Nicholas AP, Dagerlind Å, Hökfelt T: Distribution of alpha-1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. Journal of Neuroscience, 14: 4252-4268, 1994.  8027777 
Nicholas AP, Pieribone V, Dagerlind A, Meister B, Elde R, Hökfelt T: In situ hybridization. A complementary method to radioligand-mediated autoradiography for localizing adrenergic, alpha-2 receptor-producing cells. Annals of the New York Academy of Sciences 763: 222-242, 1995.  7677334 
Nicholas AP: Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex. Neuroscience Letters, 545: 107-111, 2013.  23648390 
Nicholas AP: Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience Letters, 495: 26-29, 2011.  21414385 
Nicholas AP, Buck K, Ferger B: Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity. Neuroscience Letters, 443: 204-208, 2008.  18657593 
Nicholas AP, Lubin FD, Hallett PJ, Vattem P, Ravenscroft P, Bezard E, Zhou S, Fox SH, Brotchie JM, Sweatt JD, Standaert DG: Striatal histone modifications in models of levodopa-induced dyskinesia. Journal of Neurochemistry, 106: 486-494, 2008.  18410512 
Nicholas AP: Levodopa-induced hyperactivity in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Movement Disorders, 22: 99-104, 2007.  17133519 
Nicholas AP, Sambandam T, Echols JD, Barnum SR: Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis. Journal of Comparative Neurology 486 :254-266, 2005.  15844173 
Nicholas AP, Sambandam T, Echols JD, Tourtellotte WW: Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis. Journal of Comparative Neurology 473 :128-136, 2004.  15067723 
Nicholas AP, Pieribone VA, Arvidsson U, Hökfelt T: Serotonin, substance P and glutamate/ aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate. Neuroscience, 48: 545-559, 1992.  1376453 
Nicholas AP, King JL, Sambandam T, Echols JD, Gupta KB, McInnis C, Whitaker JN: Immunohistochemical localization of citrullinated proteins in adult rat brain. Journal of Comparative Neurology 459 :251-66, 2003.  12655508 
Nicholas AP, Whitaker JN: Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain. Glia 37 :328-336, 2002.  11870872 

Keywords
Parkinson's disease, protein deimination (citrullination), levodopa-induced dyskinesia, cervical dystonia