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Faculty Detail     Name JAMES MEADOR-WOODRUFF Heman E. Drummond Professor & Chairman   Campus Address SC 560C Zip 0017 Phone 205-996-6170 E-mail jimmw@uab.edu Other websites http://www.uab.edu/medicine/jmwlab/ http://www.uab.edu/medicine/psychiatry/

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Psychiatry   Psychiatry Chair Office Professor Secondary  Neurobiology  Neurobiology Professor Center  Neurology   Alzheimer's Disease Center Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Medical Scientist Training Program  Neuroscience Graduate Program

Biographical Sketch  Undergraduate: University of Richmond, Richmond, Virginia; B.S. in Chemistry, minor subject Mathematics (1980) Medical School: Medical College of Virginia Commonwealth University, Richmond, Virginia; M.D. (1984) Residency: Department of Psychiatry, University of Michigan (1989) 1985-2006 Postdoctoral Fellow (1985-1989), Research Investigator (1990-1993), Assistant Research Scientist (1993-1995), Associate Research Scientist (1995-1997), Senior Associate Research Scientist (1997-2002), Senior Research Scientist (2002-2003), Research Professor (2003-2006), Mental Health Research Institute, University of Michigan 1989-2006 Lecturer (1989), Assistant Professor (1990-1995), Associate Professor (1995-2002), Professor (2002-2006), Department of Psychiatry, University of Michigan 1995-2002 Research Advisor (1995-1999), Director of Psychiatric Research (1999-2002), Department of Psychiatry, Ann Arbor VAMC 2000-2006 Director of Residency Research Track (2000-2006), Co-Director of Residency Clinical Scholars Track (2003-2006), Associate Chair for Research Training and Faculty Development (2001-2002), Interim Associate Chair for Research (2001-2002), Associate Chair for Research (2002-2006), Vice Chair (2004-2006), Department of Psychiatry, University of Michigan 2006-present Heman E. Drummond Professor and Chairman, Department of Psychiatry; Senior Scientist, Civitan International Research Center, Comprehensive Neuroscience Center, Center for Glial Biology in Medicine, and Center for Neurodegeneration and Experimental Therapeutics, Evelyn F. McKnight Brain Institute, Alzheimer’s Disease Research Center (ADRC); Professor of Neurobiology; University of Alabama at Birmingham 1990-1995 NIMH Research Scientist Development Award 1991 The A. E. Bennett Award 2007 APIRE/Kempf Fund Award 1995-2004 Associate Editor, Schizophrenia Bulletin 1999-2007 Editor, ACNP Scientific Website 2007-2012 Editor-in-Chief, Neuropsychopharmacology

Research/Clinical Interest Title Cellular and subcellular alterations of neural circuitry and molecular expression in schizophrenia Description Dr. Meador-Woodruff's primary research interest is on understanding how different parts of the brain communicate with other parts via a variety of chemical signals, and how this communication is disrupted in schizophrenia. His current focus is on studying the expression of genes within individual cells in the nervous system, and exploring abnormalities of receptor trafficking in the brain in schizophrenia. He has a longstanding interest in teaching and mentorship, and nearly 100 trainees have rotated through his lab.

Selected Publications  Publication PUBMEDID Hammond JV, Meador-Woodruff JH, Haroutunian V, and McCullumsmith RE: AMPA Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients With Schizophrenia. PLoS ONE. 7 (6): e39190, 2012. doi: 10.1371/journal.pone.0039190.   22720072  Rubio MD, Haroutunian V, and Meador-Woodruff JH: Abnormalities of the Duo/Ras-Related C3 Botulinum Toxin Substrate/p21-Activated Kinase 1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia. Biological Psychiatry. 71: 906-914, 2012.  22458949  Moehle MS, Luduena RF, Haroutunian V, Meador-Woodruff JH, and McCullumsmith RE: Regional Differences in Expression of Beta-Tubulin Isoforms in Schizophrenia. Schizophrenia Research. 135: 181-186, 2012.  22264600  Funk AJ, McCullumsmith RE, Haroutunian V, and Meador-Woodruff JH: Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia. Neuropsychopharmacology. 37: 896-905, 2012.  22048463  Hammond JC, McCullumsmith RE, Funk AJ, Haroutunian V, and Meador-Woodruff JH: Endosomal Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia. Schizophrenia Research. 130: 260-265, 2011.  21576009  Sodhi MS, Simmons M, McCullumsmith RE, Haroutunian V, and Meador-Woodruff JH: Glutamatergic Gene Expression is Specifically Reduced in Thalamocortical Projecting Relay Neurons in Schizophrenia. Biological Psychiatry. 70: 646-654, 2011.  21549355  McCullumsmith RE and Meador-Woodruff JH: Novel Approaches to the Study of Postmortem Brain in Psychiatric Illness: Old Limitations and New Challenges. Biological Psychiatry. 69: 127-133, 2011.  21094488  Rubio MD, Drummond JB, and Meador-Woodruff JH: Glutamate Receptor Abnormalities in Schizophrenia: Implications for Innovative Treatments. Biomolecules and Therapeutics. 20: 1-18, 2012.

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