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Faculty Detail    
Name CARMEL M MCNICHOLAS-BEVENSEE
 
Campus Address MCLM 868 Zip 0005
Phone 205-934-1785
E-mail cbevense@uab.edu
Other websites
     

Education
Undergraduate  University of Manchester, UK    1989  B.Sc. 
Graduate  University of Manchester, UK    1992  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Assistant Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Carmel McNicholas-Bevensee, Instructor, received both her B.Sc. (Hons) degree (1989) and Ph.D. (1992) from the University of Manchester (England). After completing her postdoctoral training in the Department of Cellular and Molecular Physiology at Yale University in the laboratory of Dr. Gerhard Giebisch, she worked as Research Investigator II for Bristol-Myers Squibb Pharmaceutical Research Institute. She joined the UAB faculty in 2000.

Research/Clinical Interest
Title
Regulation of ion channels of the pulmonary and cardiovascular systems
Description
My research interest focuses on the regulation and biophysical characterization of ion channels. We examine the impact of inflammation and tissue remodeling on the electrophysiological profile of cardiac myocytes and airway cells. Studies include examining the effect and underlying causes of cellular electrophysiological changes in the failing heart and the effects of release of inflammatory mediators on CFTR ion channel function in airway cells.

Selected Publications 
Publication PUBMEDID
†Roux, J., †McNicholas, C.M., †Carles, M., Goolaerts, A., Houseman, B.T., Dickinson, D.A., Iles, K.E., Ware, L.B., Matthay, M.A., Pittet, J.-F. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. (2013) FASEB J 27(3): 1095-106 † denotes equal contribution.  23221335  
Raju, S.V., Jackson, P.L., Courville, C.A., McNicholas, C.M., Sloane, P.A., Sabbatini, G., Tidwell, S., Tang, L.P., Liu, B., Fortenberry, J.A., Jones, C.W., Boydston, J.A., Clancy, J.P., Bowen, L., Accurso, F.J., Blalock, J.E., Dransfield, M.T., Rowe, S.M. (2013) Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function. Am J Respir Crit Care Med Sept 16   24040746 
Zhang, S., Blount, A.C., McNicholas, C.M., Skinner, D.F., Chestnut M., Kappes, J.C., Sorscher, E.J., Woodworth, B.A. (2013) Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability. PLoS ONE 8(11): e81589.  24282612  
Lambert, J.A., Raju, S.V., Tang, L.P., McNicholas, C.M., Li, Y., Courville, C.W., Faris, R.F., Coricor, G.E., Smoot, L.H., Mazur, M.M., Dransfield, M.T., Bolger, G.B., and Rowe, S.M. (2013) CFTR Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis. Am. J.Resp. Cell. Molec. Biol. 10.1165/rcmb.2013-0228OC  24106801  
Rooj, A.K., McNicholas, C.M., Bartoszweski, R., Bebok, Z. Benos, D.J. and Fuller, C.M. Glioma specifica cation conductance regulates migration and cell cycle progression. J Biol Chem 287(6): 4053-65, 2012.   22130665 
Kapoor, N., Lee, W., Clark, E., Bartoszewski, R., McNicholas, C.M., Latham, C.B., Bebok, Z., Parpura,V., Fuller,C.M., Palmer, C.A. and Benos, D.J. Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol 300: C1246-1259, 2011.  21346156 
McNicholas, C.M., Berecek, K.H. Mammalian target of rapamycin: MasTOR mediator of cellular changes in pathological states? Hypertension 54 (6):1221-2, 2009  19884561 
McNicholas-Bevensee, C.M., DeAndrade, K.B., Bradley, W.E., Dell'Italia, L.J., Lucchesi, P.A. and Bevensee, M.O. Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardiovasc Res 72: 262-270, 2006.  16959228 
McAlear, S.D., Liu, X., Williams, J.B., McNicholas-Bevensee, C.M. & Bevensee M.O. Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini. J Gen Physiol 127: 639-658, 2006.  16735752 
Hickman-Davis, J.M., McNicholas-Bevensee, C., Davis, I.C., Ma, H.P., Davis, G.C., Bosworth, C.A. & Matalon S. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med 173: 334-344, 2006.  16254273