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Faculty Detail     Name ROBERT E. MCCULLUMSMITH   Campus Address CIRC 576A Zip 0021 Phone 205-996-6285 E-mail smithrob@uab.edu Other websites http://www.uab.edu/medicine/jmwlab/ http://www.uab.edu/medicine/psychiatry/our-divisions/adult-ambulatory

Education Undergraduate  Indiana Univeristy, Bloomington, IN    1990  BS  Medical School  University of Michigan Medicial School, Ann Harbor, MI    1997  MD  Graduate  University of Michigan Medical School, Ann Harbor, MI    1997  PhD  Residency  University of Michigan Medical School, Ann Harbor, MI    2002  Residency

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Psychiatry   Psych - Behavioral Neurobiology Associate Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor

Graduate Biomedical Sciences Affiliations Medical Scientist Training Program

Biographical Sketch  RANK/TITLE Position: Associate Professor Department: Psychiatry & Behavioral Neurobiology Business Address: 1719 6th Avenue South, CIRC 576A Birmingham AL 35294 Phone: 205-996-6285 Fax: 205-975-4879 Email: smithrob@uab.edu HOSPITAL AND OTHER (NON ACADEMIC) APPOINTMENTS: Year/Title/Department/Institution: 2006-Present Psychiatry Attending, Department of Psychiatry & Behavioral Neurobiology, University of Alabama-Birmingham EDUCATION: Year/Degree/Institution: 1983-1986 High School Diploma Edgewood High School 1986-1988 None Hanover College 1988-1990 B.S. Biochemistry Indiana University 1990-1997 MD, PhD University of Michigan 1997-2002 Psychiatry Resident University of Michigan Hospitals LICENSURE: 2002 DEA License (#BM7836692), Expires 01/31/2014 2006 License (#498295) for State of Alabama, Expires 12/31/2013 2006 Controlled Substance License (#00027448) for State of Alabama, Expires 12/31/2013 BOARD CERTIFICATION: 2003 Board Certified in Psychiatry ACADEMIC APPOINTMENTS: Year/Rank-Title/Institution: 2002-2005 Clinical Lecturer Department of Psychiatry, University of Michigan 2002-2006 Research Investigator Mental Health Research Institute, University of Michigan 2002-2006 Assistant Director, Department of Psychiatry, University of Residency Research Track Michigan 2005-2006 Assistant Professor Department of Psychiatry, University of Michigan 2006-Present Assistant Professor Department of Psychiatry (Primary) and Neurobiology (Secondary), University of Alabama-Birmingham 2006-Present Scientist UAB Center for Glial Biology in Medicine, University of Alabama-Birmingham 2008-Present Director, Resident Department of Psychiatry, University of Outpatient Clinics Alabama-Birmingham 2009-Present Scientist UAB Comprehensive Neuroscience Center, University of Alabama-Birmingham 2011-Present Division Director, Adult Ambulatory Department of Psychiatry, University of Alabama-Birmingham 2012-Present Faculty, Graduate Graduate Biomedical Sciences (GBS), Biomedical Sciences, University of Alabama-Birmingham 2012-Present Medical Director Department of Psychiatry Eye Foundation Hospital Outpatient Clinics 2012-Present Associate Professor, Department of Psychiatry (Primary) and with Tenure Neurobiology (Secondary), University of Alabama-Birmingham AWARDS/HONORS: 1986 Superintendent's Award for Academic Merit, Edgewood High School 1989 Merck Index Award 1989 Honors Division, Indiana University, Summer Research Scholarship 1989 Harry G. Day Academic Scholarship 1990 Senior Achievement Award 1990 Churchill Scholarship Nominee, State of Indiana 1990 Phi Beta Kappa 1994 Finalist, C. Gordon Van Arman Award, Inflammation Research Association 1994 Finalist, Outstanding Scholar Award, and Presidential Travel Grant Award recipient, International Cytokine Society 1995 Student Travel Grant Award, American Society for Investigative Pathology 1999 Resident of the month, Department of Psychiatry, University of Michigan 1999 Special recognition for recruitment, Department of Psychiatry, University of Michigan 1999 The William Herdmann award for resident teacher of the year, Department of Psychiatry, University of Michigan 2000 Pfizer/University of Michigan Research Track Fellowship 2000 American Psychoanalytic Association Fellowship Award 2000 Laughlin Fellowship Award, American College of Psychiatrists 2000 Special recognition for recruitment, Department of Psychiatry, University of Michigan 2000 Special recognition for teaching undergraduates, Department of Psychiatry, University of Michigan 2000 Participant, APA Research Colloquium for Junior Investigators 2001 Special recognition for organizing Residency Research Track core, Department of Psychiatry, University of Michigan 2001 The William Herdmann award for resident teacher of the year, Department of Psychiatry, University of Michigan 2001 American College of Neuropsychopharmacology (ACNP)/Bristol-Myers Squibb Travel Award 2002 Special recognition for curriculum development, program organization, and recruitment for Residency Research Track, Department of Psychiatry, University of Michigan 2002 The Pfizer Postdoctoral Fellowship Grant in Biological Psychiatry 2002 Collegium Internationale Neuro-Psychopharmacologium (CINP) Rafaelsen Fellowship Award 2002 Rachel Upjohn Clinical Scholars Award 2002 Resident Achievement Award, Department of Psychiatry, University of Michigan 2003 Rachel Upjohn Clinical Scholars Award 2003 International Congress on Schizophrenia Research Young Investigator Award 2004 Rachel Upjohn Clinical Scholars Award 2004 Resident Teacher of the Year Award, Adult Service, University of Michigan 2005 AAP Forest Junior Faculty Development Award 2006 Resident Teacher of the Year Award, Adult Service, University of Michigan 2007 APIRE/Kempf Fund Award (Mentee) 2009 Doris Duke Charitable Foundation Clinical Scientist Award COUNCILS AND COMMITTEES: 1991 Student selection committee for MSTP-director search, University of Michigan 1993 Chair, MSTP Retreat Planning Committee, University of Michigan 1994 Pathology Doctoral Program Representative to Graduate Student Council, Medical School, University of Michigan 1994-95 President, Graduate Student Council, Medical School, University of Michigan 1995 Student selection committee for MSTP-director search, University of Michigan 1999 Class representative for resident education committee, University of Michigan 2005-2006 Summer Biomedical Research Program Review Committee, University of Michigan 2005-2008 Thesis committee member and mentor for Deborah Bauer 2006-2009 Psychiatry Residency Training Committee, University of Alabama at Birmingham 2006-present Psychiatry Training Research Committee, University of Alabama at Birmingham 2008-2011 Neuroscience Program Qualifying Exam Committee 2008-2011 Thesis committee chair and mentor for John Hammond 2008-2011 Thesis committee chair and mentor for Adam Funk 2008-present Chair, Psychiatric Research Committee, University of Alabama at Birmingham 2010-present Thesis committee for Riley Parrish 2011-present Thesis committee for Jennifer Hadley 2011-present Chair, Neuroscience Program Qualifying Exam committee 2011-present Medical Student Education Committee EDITORIAL BOARDS/REVIEWS: 2008-present Neuropsychopharmacology GRANT APPLICATION REVIEWS: 2013 Reviewer/Mentor for 17th Annual APA Research Colloquium for Junior Investigators, May 2013, APA Annual Meeting, San Francisco, California 2013 Reviewer for The Netherlands Organisation for Scientific Research (NWO), Division for Earth and Life Sciences TEACHING EXPERIENCE: 1991-97 Tutor and small group facilitator for Post-Baccalaureate Program and Office of Student Affairs 1996 Facilitator for first year medical student small group education 1998 Guest Speaker, Fairfax High School, Los Angeles, CA, “How to go to college and become a health professional,” (10/98) 1998-00 Instructor, M3 psychiatric clerkship review session 1999 Instructor for undergraduate course “The Psychiatric Patient” 1999 Medical student research rotation lecture: From PCR to the clinic (9/99) 2000 Instructor for first year medical student small group education 2000 Instructor for undergraduate course “The Psychiatric Patient, Part II” 2000 Medical student research rotation lecture: From PCR to the clinic (9/99) 2000-06 Course Director for Clinical Educator and Residency Research Track core lecture series, Department of Psychiatry, University of Michigan 2002 Keynote speaker, Greenhills High School Annual Day, Ann Arbor, MI (4/02) 2002 Residency Research Track core lecture: Mental Health Research Training (7/22/02) 2002 Residency Research Track core lecture: Primer of Biostatistics (8/26/02) 2003 Residency Research Track core lecture: The Clinic/ward and time management (1/13/03) 2003 Residency Research Track core lecture: Principles of Didactic Teaching (4/07/03) 2003 Residency Research Track core lecture: Outpatient Psychiatry for split time residents: Part 1 (6/23/03) 2003 Residency Research Track core lecture: Outpatient Psychiatry for split time residents: Part 2 and follow-up (8/25/03) 2003 Instructor for the Difficult Patient Workshop (8/27/03) 2004 Residency Research Track core lecture: Basic Statistics: regression (1/19/04) 2004 Residency Research Track core lecture: How to use Endnote (3/8/04) 2004 Residency Research Track core lecture: Basic Statistics: ANOVA (4/5/04) 2004 Psychopharmacology update: "Schizophrenia as a disorder of Neuroplasticity” (7/10/04) 2004 Residency Research Track core lecture: Outpatient Psychiatry for split time residents: Part 1 (7/19/03) 2004 PGY IV core lecture: Dopaminergic neurotransmission and psychiatric illness 2004 Residency Research Track core lecture: Gifts and Big Pharma (7/26/04) 2004 Instructor for the Difficult Patient Workshop (8/12/04) 2004 Residency Research Track core lecture: Outpatient Psychiatry for split time residents: Part 2 and follow-up (8/16/03) 2004 Adult Residency didactic: Modeling drug representative-physician interactions (8/19/04) 2004 PGY IV core lecture: Glutamatergic neurotransmission and psychiatric illness 2005 Residency Research Track core lecture: How to make a poster (1/24/05) 2005 Advanced Clinical Skills Mentorship: Mock oral board exam (4/20/05) 2005 Advanced Clinical Skills Mentorship: Mock oral board exam (4/27/05) 2005 Residency Research Track core lecture: How to supervise undergraduates (5/9/05) 2005 VA interns core lecture: Suicidality and safety (7/7/05) 2005 Residency Research Track core lecture: How to write a review article (7/18/05) 2005 VA Grand Rounds: Responding to difficult patients in the moment (7/19/05) 2005 Instructor for the Difficult Patient Workshop (8/10/05) 2005 Mock oral board exam for Psychiatry Faculty (8/12/05) 2005 Instructor for the yearlong HOIII and HOIV scholarly project core 2005 Residency Research Track core lecture: Writing Tools I (10/3/05) 2005 PGY IV core lecture: Glutamatergic neurotransmission and psychiatric illness (12/8/05) 2006 Advanced Clinical Skills Mentorship: Mock oral board exam (1/06/06) 2006 Advanced Clinical Skills Mentorship: Mock oral board exam (1/27/06) 2006 PGY3 core lecture: Neurotransmitters in psychiatric illness (10/25/06) 2006 PRA residents meeting: Negotiating Jobs (11/2/06) 2006-present Faculty Consultation Clinic: Weekly Group supervision and Clinical Team meeting for PGY3 Psychiatry Residents 2007 PGY2 Research core: Prospective research projects (1/30/07) 2007 PGY3 core lecture: Glutamate in schizophrenia (2/7/07) 2007 MS1 Behavioral Science course: Personality Disorders (5/15/07) 2007 PGY3 Mock oral board exam (5/17/07) 2007 MS1 Behavioral Science course: Personality Disorders (5/29/07) 2007 Graduate Neuroscience course, group facilitator: Translational neuroscience (5/31/07) 2007 Graduate School lecture: Current hypotheses for schizophrenia (7/18/07) 2007 PGY3 Mock oral board exam (5/17/07) 2007 PGY3 Mock oral board exam (11/15/07) 2008 PGY3 Mock oral board exam (1/17/08) 2008 Palliative Care Fellows conference: Managing difficult patients (2/4/08) 2008 Palliative Care nursing rounds: Managing difficult patients (2/15/08) 2008 PGY3 Mock oral board exam (3/13/08) 2008 PGY3 research project review (3/27/08) 2008 PGY3 core lecture: Glutamate receptor trafficking (4/23/08) 2008 PRA residents meeting: Interpreting industry sponsored clinical research (4/24/08) 2008 PGY3 research project review (4/24/08) 2008 PGY3 Mock oral board exam (5/29/08) 2008 PGY4 Mock oral board exam (7/29/08) 2008 PGY3 core lecture: Books you should read (9/10/09) 2008 MS1 Behavioral Science course: Personality Disorders (10/20/09) 2008 MS2 Small group facilitator: Anxiety Disorders (10/20/09) 2008 PGY3 core lecture: Principles of Synaptic plasticity (10/22/09) 2008 MS2 Small group facilitator: Depression (10/28/09) 2009 Neuroscience 723 lecture: The Preliminary Data Section (3/3/09) 2009 PGY2 core lecture: Glutamatergic drugs (4/8/09) 2009 PGY4 Mock oral board exam (5/8/09) 2009 PGY4 Mock oral board exam (5/28/09) 2009 PGY4 Mock oral board exam (6/11/09) 2009 MS1 Behavioral Science course: Personality Disorders (11/13/09) 2010 Didactic for the counseling and wellness staff: Suicidal ideation (4/7/10) 2010 Graduate Neuroscience course, group facilitator: Translational neuroscience (4/10) 2010 Neuropharmacology: Anti-anxiety drugs (5/21/10) 2010 Neuropharmacology: Anti-depressant drugs (5/24/10) 2010 Neuropharmacology: Anti-psychotic drugs (5/26/10) 2011 Graduate Neuroscience course, group facilitator: Translational neuroscience (2/23/11) 2011 PGY4 Mock oral board exam (3/11/11) 2011 PGY4 Mock oral board exam (3/25/11) 2011 PGY4 Mock oral board exam (3/28/11) 2011 Didactic for the counseling and wellness staff: Suicidal ideation (4/27/11) 2011 Anti-anxiety and anti-psychotics for Qin Wang (5/25/11) 2011 Anti-anxiety and anti-psychotics for Qin Wang (6/1/11) 2011 Anxiety Disorders seminar (6/20/11) 2011 UAB School of Nursing on "Update on Personality Disorders" (6/24/11) 2011 Summer Lab Lecture Series (6/24/11) 2011 Medical student anxiety disorders seminar (7/1/11) 2011 Students’ anxiety disorders seminar (8/1/11) 2011 Neuroscience Oral QE (8/19/11) 2011 Psychosocial and Spiritual Transference and Countertransference (9/30/11) 2011-present Resident Psychotherapy Clinic: Weekly Group supervision and Clinical Team meeting for PGY2 Psychiatry Residents 2011 Medical Neuroscience “Brain” Module – Personality Disorders (11/9/11) 2012 Graduate Neuroscience: Affective Disorders (2/20/12) 2012 Didactic for the counseling and wellness staff: Countertransference (5/16/12) 2012 Neuroscience Oral QE (6/20/12, 6/26/12, 8/23-24/12, 11/2/12) 2012 Undergraduate Neuroscience Colloquium (11/2/12) 2012 Neuropharmacology: Anxiolytic drugs (11/12/12) 2012 Neuropharmacology: Anti-psychotic drugs (11/14/12) 2012 Medical Neuroscience “Brain” Module – Personality Disorders (12/6/12) 2012 Neuroscience “Brain” Module – Personality Disorders (12/10/12) GRANT SUPPORT: Completed Grant Support: Rachel Upjohn Clinical Scholars Program, University of Michigan. “Characterization of glutamatergic circuits following modulation of serotonergic neurotransmission in the rat brain.” Support for laboratory-related expenses for Robert McCullumsmith, M.D., Ph.D. James H. Meador-Woodruff, M.D., Sponsor. 7/1/03-6/30/04. Rachel Upjohn Clinical Scholars Program, University of Michigan. “Characterization of glutamatergic neurotransmission in the medial temporal lobe in bipolar disorder.” Support for laboratory-related expenses for Robert McCullumsmith, M.D., Ph.D. James H. Meador-Woodruff, M.D., Sponsor. 7/1/04-6/30/05 Pfizer Postdoctoral Fellowship Program. “A study of Glutamatergic Corticothalamic Circuitry in Schizophrenia.” Postdoctoral fellowship for Robert McCullumsmith, M.D., Ph.D., James H. Meador-Woodruff, M.D., Sponsor. 7/1/02-6/30/05. The Stanley Foundation. "NMDA Receptor Trafficking Abnormalities in Schizophrenia." J.H. Meador-Woodruff, Principal Investigator. 8/1/04-7/31/06. Dr. McCullumsmith is a co-investigator. HSF-GEF Scholar's. Glutamate transporter expression in severe psychiatric illness. Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 4/1/06-3/31/09. NIMH, #R01 MH070895. “Thalamic Glutamate Dysregulation in Schizophrenia.” James H. Meador-Woodruff, M.D., Principal Investigator. 12/15/04-11/30/09. (Total Direct Costs: $900,000). Dr. McCullumsmith is a co-investigator. NIMH, #R01 MH53327. "Subcellular Glutamate Defects in Schizophrenia." James H. Meador-Woodruff, M.D., Principal Investigator. 7/1/06-6/30/11. (Total Direct Costs: $1,659,444). Dr. McCullumsmith is a co-investigator. NIMH, #K08 MH074016. "Glutamate transporter expression in Schizophrenia." Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 7/1/06-6/30/11.(Total Direct Costs: $901,800). Mentor: James H. Meador-Woodruff. Doris Duke Clinical Scientist Development Award. "Abnormalities of glutamate transporter localization in schizophrenia." Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 8/1/09-7/31/12. (Total Direct Costs: $375,000) Ongoing Grant Support: NIMH, R01 #MH094445. “Defects of subcellular glutamate transporter localization in schizophrenia." Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 7/1/11-6/30/16. (Total Direct Costs: $1,125,000) NIMH, F30 #MH086257. "AMPA Receptor Trafficking in Schizophrenia." John H. Hammond, Applicant, Robert E. McCullumsmith, M.D., Ph.D., Sponsor and Principal Investigator. 12/1/09-1/1/14 (Total Direct Costs: $159,996). NIMH, R21 #MH087752. "Abnormalities of glutamate transporter localization in schizophrenia." Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 12/1/10-8/30/13. (Total Direct Costs: $275,000) Pending support: NIMH, R01 MH100101. "Striatal glutamate and spine pathology in schizophrenia and treatment response." Rosalinda Roberts Ph.D., Principal Investigator, Dr. McCullumsmith is a co-investigator. 9/1/13-8/31/18. (Total Direct Costs: $1,250,000) NIMH, R01 #MH100102. "Abnormalities of glutamate microdomains in schizophrenia." Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator; with Rosalinda Roberts (Multi-PI). 9/1/13-8/31/18. (Total Direct Costs: $1,250,000) NIMH, R21, “NMDAR hypofunction and defective protein palmitoylation in schizophrenia.” Janusz Tucholski, Ph.D., Principle Investigator; Robert E. McCullumsmith, M.D., Ph.D., Consultant. 10/1/13-9/30/15 (Total Direct Costs: $275,000) NIMH, R21 #100625, “Characterization of CCK-positive Interneurons in Schizophrenia.” Robert E. McCullumsmith, M.D., Ph.D., Principal Investigator. 10/1/13-9/30/15 (Total Direct Costs: $275,000) NIMH, R21, “Cell-specific analysis of sub-kinomes in schizophrenia”; Robert E. McCullumsmith, M.D., Ph.D., Principle Investigator. 10/1/13-9/30/15 (Total Direct Costs: $275,000)

Society Memberships Organization Name Position Held Org Link American College of Neuropsychopharmacology  Associate Member  http://www.acnp.org/  American Psychiatric Association  Member  http://www.psych.org/  International Cytokine Society  Member  http://www.isicr.org/  Society for Neuroscience  Member  http://www.sfn.org/

Research/Clinical Interest Title Description I am interested in asking and answering the largest possible question related to the pathophysiology of schizophrenia. I am currently funded to explore mechanisms of altered glutamate reuptake in corticothalamic circuits in this illness.

Selected Publications  Publication PUBMEDID R. E. McCullumsmith, J. H. Meador-Woodruff. (2013) Abnormalities of protein trafficking, signaling, and posttranslational modifications in schizophrenia. Neuropharmacology Reviews. Submitted.    J.C. Hammond, D. Shan, J. H. Meador-Woodruff, and R. E. McCullumsmith. (2013). Evidence of glutamatergic dysfunction in the pathophysiology of schizophrenia. In M. Popoli, D. Diamond, G. Sanacora (Eds.), Stress at the Synaptic Level: Synaptic stress and pathogenesis of neuropsychiatric disorders. New York, NY: Springer Science+Business Media, LLC.    J.C. Hammond, D. Shan, J. H. Meador-Woodruff, and R. E. McCullumsmith. (2013). Evidence of glutamatergic dysfunction in the pathophysiology of schizophrenia. In M. Popoli, D. Diamond, G. Sanacora (Eds.), Stress at the Synaptic Level: Synaptic stress and pathogenesis of neuropsychiatric disorders. New York, NY: Springer Science +Business Media, LLC.    K. Marballi, R. E. McCullumsmith, S.D. Yates, M. Escamilla, R. Leach, H. Raventos, C. Walss-Bass. (2013) Global signaling effects of a rare functional schizophrenia-associated missense variant in neuregulin 1: A whole genome and novel kinome approach. Molecular Psychiatry. Submitted.    J. Tucholski, M.S. Simmons, A.L. Pinner, V. Haroutunian, J. H. Meador-Woodruff, and R. E. McCullumsmith, J.H. Meador-Woodruff. (2013) Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia. Schizo. Res., pii: S0920-9964 (13)00069-8.  http://www.ncbi.nlm.nih.gov/pubmed/23462048  R.E. McCullumsmith, John Hammond, Adam Funk, and J.H. Meador-Woodruff. Recent Advances in Targeting the Ionotropic Glutamate Receptors in Treating Schizophrenia. 2012. Illinois: Bentham Science Publishers.  http://www.ncbi.nlm.nih.gov/pubmed/22283761  D. Shan, S.D. Yates, R. Roberts, and R.E. McCullumsmith. (2012). Update on the Neurobiology of Schizophrenia: a Role for Extracellular Microdomains. Minerva Psichiatrica; 53(3):233-49.  http://www.minervamedica.it/en/journals/minerva-ps  M. S. Moehle, R. F. Luduena, V. Haroutunian, J. H. Meador-Woodruff, and R. E. McCullumsmith. (2012). Regional differences in expression of beta-tubulin isoforms in schizophrenia. Schizo. Res., 135: 181-186.    D. Shan, V. Haroutunian, J. H. Meador-Woodruff, and R. E. McCullumsmith. (2012). Expression of ENT1 protein in Elderly Patients with Schizophrenia. NeuroReport, 23:224-227.  http://www.ncbi.nlm.nih.gov/pubmed/22314683  J. Hammond, J.H. Meador-Woodruff, V. Haroutunian, and R.E. McCullumsmith. (2012). AMPA Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients with Schizophrenia. PloS one 7(6): e39190.  http://www.plosone.org/article/info%3Adoi%2F10137  First Prev   1 2 of  2  Next Last

Keywords schizophrenia, glutamate, EAAT2

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