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Faculty Detail     Name QIANA L MATTHEWS Assistant Professor of Medicine   Campus Address BBRB 566 Zip 2170 Phone 205-934-0573 E-mail qlm@uab.edu Other websites Medicine/ Infectious Diseases

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Infectious Diseases Assistant Professor Secondary  Microbiology  Microbiology Assistant Professor Center  Center for AIDS Research  Center for AIDS Research Assistant Professor

Biographical Sketch  Dr. Qiana L. Matthews completed her undergraduate studies in Biology at Clark Atlanta University in 1999. She obtained her PhD in 2003 from Meharry Medical College, Nashville TN (USA). Dr. Matthews went on to complete a postdoctoral fellowship in the Division of Human Gene Therapy, at the University of Alabama at Birmingham (UAB), (2003-2008). Currently, Dr. Matthews is working as a molecular virologist. She is working with adenoviral vectors for gene therapy, virotherapy, and vaccine applications. Dr. Matthews is an Associate Scientist in the Center for AIDS Research as well as an Assistant Professor in the Department of Medicine/Division of Infectious Diseases.

Research/Clinical Interest Title Next generation adenoviruses for improved vaccines and therapies Description Our main research area concentrates on developing a safe and effective HIV vaccine using human adenovirus (Ad)-based delivery strategies. In this regard, we focus on modifying adenovirus vectors to exhibit less (Ad5) vector immunogenicity, while focusing the immune response to HIV antigens by means of a novel chimeric Ad vector platform, antigen presentation, and immune activation platform. Our other interest in the laboratory include: (i) developing gene therapy models that will contribute to the advancement of biomedical sciences and human health. (ii) developing safe and effective vaccines for other infectious diseases. (iii) developing novel approaches to treat and HIV-associated malignancies. (iv) developing novel approaches to treat Uterine Leiomyoma.

Selected Publications  Publication PUBMEDID Bone RN, Icyuz M, Zhang Y, Zhang Y, Cui W, Wang H, Peng JB, Matthews QL, Siegal GP, Wu H. Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts& b-cell survival and proliferation differentially in vitro and in vivo. Islets. 2012 Nov 1;4(6).   23183538  Liu RM, Vayalil PK, Ballinger C, Dickinson DA, Huang WT, Wang S, Kavanagh TJ, Matthews QL, Postlethwait EM.Transforming growth factor beta suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.Free Radic Biol Med. 2012 Aug 1;53(3):554-63.   22634145  Gamble LJ, Borovjagin AV, Matthews QL. Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review). Exp Ther Med. 2010 Mar;1(2):233-240.   21494315  Gamble LJ, Matthews QL. Current progress in the development of a prophylactic vaccine for HIV-1. Drug Des Devel Ther. 2010 Dec 22;5:9-26.   21267356  Matthews QL. Capsid-incorporation of antigens into adenovirus capsid proteins for a vaccine approach. Mol Pharm. 2011 Feb 7;8(1):3-11.  21047139  Matthews QL, Fatima A, Tang Y, Perry BA, Tsuruta Y, Komarova S, Timares L, Zhao C, Makarova N, Borovjagin AV, Stewart PL, Wu H, Blackwell JL, Curiel DT. HIV antigen incorporation within adenovirus hexon hypervariable 2 for a novel HIV vaccine approach. PLoS One. 2010 Jul 27;5(7):e11815  20676400  Li J, Fatima A, Komarova S, Ugai H, Uprety P, Roth JC, Wang M, Oster RA, Curiel DT, Matthews QL. Evaluation of adenovirus capsid labeling versus transgene expression. Virol J. 2010 Jan 26;7:21.   20102632  Tang Y, Wu H, Ugai H, Matthews QL, Curiel DT. Derivation of a triple mosaic adenovirus for cancer gene therapy. PLoS One. 2009 Dec 31;4(12).   20046872  Thacker EE, Timares L, Matthews QL. Strategies to overcome host immunity to adenovirus vectors in vaccine development. Expert Rev Vaccines. 2009 Jun;8(6):761-77.   19485756  Matthews QL, Yang P, Wu Q, Belousova N, Rivera AA, Stoff-Khalili MA, Waehler R, Hsu HC, Li Z, Li J, Mountz JD, Wu H, Curiel DT. Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach. Virol J. 2008 Aug 21;5:98.  18718011  First Prev   1 2 of  2  Next Last

Keywords vaccines, HIV, adenovirus, gene therapy

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