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Faculty Detail     Name LING LI   Campus Address BDB 630 Zip 0012 Phone 612-626-2359 E-mail lili@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med-Gerontology/Geriatrics/Palliative Care Professor Adjunct

Graduate Biomedical Sciences Affiliations Genetics and Genomic Sciences  Integrative Biomedical Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program  Neuroscience  Pathobiology and Molecular Medicine

Biographical Sketch  1982 - B.S./D.V.M. equivalent, Vet. Medicine, Yangzhou Univ., China 1986 - M.S., Vet./Experimental Pathology, Yangzhou Univ., China 1995 - Ph.D., Molecular, Cellular, and Developmental Biology, Iowa State Univ., Ames, IA 1995-1996 Postdoctoral Research Associate, Rockefeller Univ./Mt. Sinai Medical Center, NY 1997-1999 Postdoctoral Fellow, UAB, Birmingham, AL 1999-2006 Assistant Professor, Medicine (primary), Genetics (secondary), Pathology (secondary), Neurobiology (secondary), UAB, Birmingham, AL 2006-present Associate Professor (with tenure in 2008), Medicine (primary), Genetics (secondary), Pathology (secondary), Neurobiology (secondary), UAB, Birmingham, AL

Society Memberships Organization Name Position Held Org Link American Association for the Advancement of Science      American Society for Biochemistry and Molecular Biology      Society for Neuroscience

Research/Clinical Interest Title Connections Between Atherosclerosis, Diabetes, and Alzheimer's Disease Description Our research interest is focused on the genetic and pathophysiological connections between atherosclerosis, diabetes, and Alzheimer’s disease (AD) using transgenic/knockout mouse models. We employ a combination of molecular, cellular, electrophysiological, and behavioral approaches in our research. Current research activities in our laboratory include: 1) Investigation on the protective mechanisms of cholesterol-lowering drug (statins) in AD and other age-related dementia; 2) Pathogenic and therapeutic connections between insulin resistance, diabetes, and AD; 3) Role of dietary and/or genetically induced hypercholesterolemia in the development of AD-like neuropathology and behavior in transgenic mouse models of AD; 4) Role of amyloid-beta peptide in atherogenesis; and 5) Structure and function of apolipoprotein A-I, a major protein component of the cardio-protective high-density lipoproteins.

Selected Publications  Publication PUBMEDID Mans RA, Chowdhury N, Cao D, McMahon L, Li L. Simvastatin enhances spatial learning and hippocampal long-term potentiation in C57BL/6 mice. Neuroscience. 2010; 166: 435-444.  20040368  Handattu SP, Garber DW, Monroe CC, van Groen T, Kadish I, Nayyar G, Cao D, Palgunachari MN, Li L, Anantharamaiah GM. Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009; 34:525-534.  19344763  Li L, Cao D, Desmond R, Rahman A, Lah JJ, Levey AI, Zamrini E. Cognitive performance and plasma levels of homocysteine, vitamin B12, folate, and lipids in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord. 2008; 26:384-390.  18931498  Li L, Weng W, Fisher EA. Plasma carboxyl ester lipase activity modifies apoB-lipoprotein composition and turnover but has no effect on atherosclerosis in a transgenic mouse model. Metabolism. 2008; 57:1361-68.  18803939  Jin J, Kim H, Maxwell JA, Li L, Fukuchi K. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation 2008; 5:23.  18510752  Cao D, Lu H, Lewis TL, Li L. Intake of Sucrose-Sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer’s Disease. J Biol Chem. 2007; 282: 36275-36282.  17942401  Wavrant-De Vrièze F, Compton D, Womick M, Arepalli S, Adighibe O, Li L, Pérez-Tur J, Hardy J. ABCA1 polymorphisms and Alzheimer’s disease. Neurosci Lett. 2007; 416:180–183.  17324514   Li L, Cao D, Kim H, Lester R, Fukuchi K. Simvastatin enhances learning and memory independent of amyloid load in mice. Annals Neurol. 2006; 60:729-39.  17192930  Tahara K, Kim HD, Jin J, Maxwell JA, Li L, Fukuchi K. Role of toll-like receptor signaling in Ab uptake and clearance. Brain. 2006; 129:3006-19.  16984903  Catte A, Patterson JC, Jones MK, Jerome WG, Bashtovyy D, Su Z, Gu F, Chen J, Aliste MP, Harvey SC, Li L, Weinstein G, Segrest JP. Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study. Biophys J. 2006; 90:4345-60.  16581834  First Prev   1 2 of  2  Next Last

Keywords Alzheimer's disease, choelsterol, lipoproteins, atherosclerosis, statins, diet, insulin, diabetes, learning and memory

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