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Faculty Detail     Name CORINNE E GRIGUER   Campus Address WTI 420- Zip 0000 Phone 205-934-8297 E-mail cgriguer@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Surgery   Surgery - Neurosurgery Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor

Research/Clinical Interest Title Mitochondria in brain cancer Description Tumor formation can be regarded as the process by which cells evolve via progressive selection under various stringent conditions, such as low oxygen and nutrients. There are strong relationships between metabolic pathways, such as glycolysis and respiration, which operate as an integrated unit often able to correct genetic or other insults by “seeking out” and/or bypassing the affected enzyme or abnormal substrate. This adaptation was described first by Warburg, who predicted that cancer cells have impaired respiration and up-regulated glycolysis. Warburg’s molecular-based observations are now being recognized with the discovery of major transcription factors such as HIF-1a induced during hypoxia. Other studies have demonstrated that proto-oncogenes, such as AKT, c-myc, and more recently, tumor suppressor p53, are regulated by a tumor micro-environment. While the scientific community is beginning to gain insights into the origin of cancer through genetic mutations, deletion, and amplification, others’ mission is to understand how the micro-environment affects tumor initiation, survival, and progression. Understanding the molecular pathways by which the modulation of cellular energy acts will provide new insights into how bio-energetic stress at the level of oxidative phosphorylation could impact cell cycle progression. It will also provide insight into new therapeutic strategies to control glioma cell initiation, proliferation, and progression. Dr. Griguer's research interests center on bioenergetics pathways involved in the development and progression of malignant glioma, and translating findings from the laboratory into the clinical arena. Two main topics are study in her laboratory: the role of mitochondrial bioenergetics in chemoresistance and the role of mitochondria in stem cells biology.

Selected Publications  Publication PUBMEDID Oliva CR, Nozell SE, Diers A, McClugage SG 3rd, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE. (2010) Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. J Biol Chem. (2010 September 24, doi: 10.1074/jbc.M110.147504)   20870728  C.E.Griguer,C.R. Oliva,E. Gobin,P. Marcorelles, D.J. Benos, J. R. Lancaster, Jr,G.Y Gillespie CD133 is a marker of bioenergetic stress in human glioma PLoS ONE. 2008; 3(11): e3655.   18985161   Oliva, CR,Swiecki, MK.,Griguer, CE.,Lisanby,MW.,Bullard, DC, Turnbough, Jr., Kearney, JF. The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1261-6. Epub 2008 Jan 23.   18216258  Griguer CE, Oliva CR, Gillespie GY, Gobin E, Marcorelles P. Pharmacologic manipulations of mitochondrial membrane potential (DeltaPsim) selectively in glioma cells. J.Neurooncology, 81, 9-20, (2007)  16862448  C.E. Griguer, C.R. Oliva, E.E Kelley, G.I. Giles, J.R. Lancaster Jr., G.Y. Gillespie. Xanthine Oxidase-dependent Regulation of Hypoxia-Inducible Factor in Cancer Cells. Cancer Res. 66 (4), 2257-2263 (2006)  16489029  CE. Griguer, C.R. Oliva, GY Gillespie. Glucose Metabolism Heterogeneity in Human and Mouse Malignant Glioma Cell Lines. J Neurooncol. 2005 Sep; 74(2):123-33.  16193382

Keywords Glioma, Mitochondria, bioenergetic, Chemoresistance, CD133 , cytochrome c oxidase, HIF-1a, glycolysis,

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